Abstract:
:The increase in plasma prolactin which follows intravenous administration of L-tryptophan (LTP) was used to assess changes in brain 5-hydroxytryptamine (5-HT) function in normal male and female subjects, following a three week period of dieting. In women, but not men, there was a marked increase in the prolactin response to LTP, suggesting that dieting had caused alterations in brain 5-HT-mediated responses. In contrast, dieting did not alter the prolactin response to thyrotropin releasing hormone in either men or women, indicating that the changes in response to LTP could not be attributed to an increase in pituitary reserve of prolactin. These findings suggest that dieting alters brain 5-HT function in women but not in men. Biological factors as well as greater psychosocial pressures to diet may contribute to the high prevalence of eating disorders amongst women.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Goodwin GM,Fairburn CG,Cowen PJdoi
10.1017/s0033291700000635subject
Has Abstractpub_date
1987-11-01 00:00:00pages
839-42issue
4eissn
0033-2917issn
1469-8978journal_volume
17pub_type
杂志文章abstract:BACKGROUND:There are no tested methods for conducting epidemiological studies of autism spectrum disorders (ASDs) in adult general population samples. We tested the validity of the Autism Diagnostic Observation Schedule module-4 (ADOS-4) and the 20-item Autism-Spectrum Quotient (AQ-20). METHOD:Randomly sampled adults ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711001292
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Recent cross-sectional studies have shown psychotic experiences (PEs) are associated with suicidal ideation and behaviours. We aimed to examine associations between psychotic experiences (including persistent PE), and contemporaneous and incident non-suicidal self-injury (NSSI) and suicide attempts. METHOD:...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714001615
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000980
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Current mental health legislation in the UK makes provision for the use of certain treatments in severely ill patients who are unable, or unwilling, to give informed consent. Under the terms of this legislation, electroconvulsive therapy (ECT) may be used, usually to treat severely depressed patients. A numb...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007193
更新日期:1999-01-01 00:00:00
abstract::Fifty patients with bulimia nervosa were followed up for a minimum length of 5 years. Standardized interviews, observer-rated instruments and self-rated questionnaires were employed both at entry and at completion of the follow-up period. After tracing, the positive response rate was 72%; one patient had died. At the ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700038526
更新日期:1992-11-01 00:00:00
abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700024934
更新日期:1987-05-01 00:00:00
abstract::Several studies have suggested that 'anomalous parenting', as measured by the Parental Bonding Instrument (PBI), may be a differential risk factor to subsequent depression in adulthood--being irrelevant to melancholia but over-represented in non-melancholic depressive disorders. Such a 'specificity' effect is confirme...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700038101
更新日期:1992-08-01 00:00:00
abstract::Suicides and suicide attempts in cancer patients were analysed by following all patients treated for cancer in Stockholm County from 1975 to 1985. Among 59,845 patients we identified 144 suicides and 196 suicide attempts during the follow-up, which represents a more than two-fold excess mortality from suicide and a mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029962
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:The coronavirus [coronavirus disease 2019 (COVID-19)] pandemic has introduced extraordinary life changes and stress, particularly in adolescents and young adults. Initial reports suggest that depression and anxiety are elevated during COVID-19, but no prior study has explored changes at the within-person lev...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720005358
更新日期:2021-01-13 00:00:00
abstract:BACKGROUND:Preparing for potentially threatening events in the future is essential for survival. Anticipating the future to be unpleasant is also a cognitive key feature of depression. We hypothesized that 'pessimism'-related emotion processing would characterize brain activity in major depression.MethodDuring function...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991073
更新日期:2010-05-01 00:00:00
abstract::Eighty-three chronic obstructive bronchitic patients were psychologically assessed before being randomly allocated to 1 of 3 management regimes. The following measures were taken: psychiatric disturbance, personality, social-desirability response set, vocabulary, expectations about treatment, attitudes and beliefs abo...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291700021565
更新日期:1979-02-01 00:00:00
abstract:BACKGROUND:Previous imaging studies have revealed that acute major depression is characterized by altered neural responses to negative emotional stimuli. Typically, responses in limbic regions such as the amygdala are increased while activity in cortical regulatory regions such as the dorsolateral prefrontal cortex (DL...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709990596
更新日期:2010-03-01 00:00:00
abstract::Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700030865
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:This study seeks to clarify the contribution of temporally stable and occasion-specific genetic and environmental influences on risk for major depression (MD). METHOD:Our sample was 2153 members of female-female twin pairs from the Virginia Twin Registry. We examined four personal interview waves conducted ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000277
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Social media platforms have long been recognised as major disseminators of health misinformation. Many previous studies have found a negative association between health-protective behaviours and belief in the specific form of misinformation popularly known as 'conspiracy theory'. Concerns have arisen regardi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000224X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Patient satisfaction is a key indicator of inpatient care quality and is associated with clinical outcomes following admission. Different patient characteristics have been inconsistently linked with satisfaction. This study aims to overcome previous limitations by assessing which patient characteristics are ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291719000011
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Hip fracture is common in the elderly. Previous studies suggest that psychiatric illness is common and predicts poor outcome, but have methodological weaknesses. Further studies are required to address this important issue. METHODS:We prospectively recruited 731 elderly participants with hip fracture in two...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002548
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703007475
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Little is known about the association of eating disorder subtypes across multiple categories of substance use in population-based samples. We examined the association between eating disorders and substance use in a large population-based sample. METHOD:Female participants (n=13 297) were from the Swedish Tw...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709005662
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Mental stress is associated with higher mortality, but it remains controversial whether the association is causal or a consequence of a higher physical disease burden in those with a high mental stress load. Understanding causality is important when developing targeted interventions. We aimed to estimate the...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002380
更新日期:2018-07-01 00:00:00
abstract::A standardized pegboard task was used to investigate changes in manipulative skill as a function of age in 119 right-handed subjects. The typical pattern of cognitive impairment in old age indicates a relative preservation of functions which depend on the integrity of the left hemisphere. In accord with these observat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005109
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Health anxiety (HA) is associated with increased risk of disability, increased health care utilization and reduced quality of life. However, there is no consensus on which factors are important for the level of HA. The aim of this study was to explore the distribution of HA in a general adult population and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004122
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Impaired emotion regulation may underlie exaggerated emotional reactivity in patients with obsessive compulsive disorder (OCD), yet instructed emotion regulation has never been studied in the disorder. METHOD:This study aimed to assess the neural correlates of emotion processing and regulation in 43 medicat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001026
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:The extant major psychiatric classifications, DSM-IV and ICD-10, are purportedly atheoretical and largely descriptive. Although this achieves good reliability, the validity of a medical diagnosis is greatly enhanced by an understanding of both risk factors and clinical history. In an effort to group mental d...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709990304
更新日期:2009-12-01 00:00:00
abstract::Between 1968 and 1975 there was a marked, non-artefactual rise in the numbers of young female parasuicides admitted to the Regional Poisoning Treatment Centre in Edinburgh. The greatest increase in rates occurred among girls aged 15--19 (for events, persons and 'first-ever' episodes). Among teenagers the most marked i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700032013
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:Neuroticism has been shown to increase the risk of depression whereas extraversion is associated with a reduction of risk. These personality traits play a central role in aetiological theories of affective disorder but their role in schizophrenia is unclear. In this study, the risk for schizophrenia associat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004044
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:The usefulness of any diagnostic scheme is directly related to its ability to provide clinically useful information on need for care. In this study, the clinical usefulness of dimensional and categorical representations of psychotic psychopathology were compared. METHOD:A total of 706 patients aged 16-65 ye...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291798008162
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND:Several studies have reported smaller hippocampal volume (HcV) in depression patients; however, the temporality of the association remains unknown. One proposed hypothesis is that depression may cause HcV loss. This study evaluates whether previous depression and recent depressive symptoms are associated wit...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714003055
更新日期:2015-07-01 00:00:00
abstract::A Fijian community affected by a cyclone was compared with an unaffected but similar community. Two months after the cyclone both psychological and physical morbidity was 2-3 times greater in the affected community than in controls. By the third month morbidity had resolved to levels similar to those in the unaffected...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700010412
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Interest in the mental health of women deployed to modern military campaigns is increasing, although research examining gender differences is limited. Little is known about experiences women have had on these deployments, or whether men and women respond differently to combat exposure. METHOD:The current st...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171100290X
更新日期:2012-09-01 00:00:00