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Depressive symptom clusters are differentially associated with atherosclerotic disease.

Abstract：

BACKGROUND:Depression increases the risk of subsequent vascular events in both cardiac and non-cardiac patients. Atherosclerosis, the underlying process leading to vascular events, has been associated with depression. This association, however, may be confounded by the somatic-affective symptoms being a consequence of cardiovascular disease. While taking into account the differentiation between somatic-affective and cognitive-affective symptoms of depression, we examined the association between depression and atherosclerosis in a community-based sample. METHOD:In 1261 participants of the Nijmegen Biomedical Study (NBS), aged 50-70 years and free of stroke and dementia, we measured the intima-media thickness (IMT) of the carotid artery as a measure of atherosclerosis and we assessed depressive symptoms using the Beck Depression Inventory (BDI). Principal components analysis (PCA) of the BDI items yielded two factors, representing a cognitive-affective and a somatic-affective symptom cluster. While correcting for confounders, we used separate multiple regression analyses to test the BDI sum score and both depression symptom clusters. RESULTS:We found a significant correlation between the BDI sum score and the IMT. Cognitive-affective, but not somatic-affective, symptoms were also associated with the IMT. When we stratified for coronary artery disease (CAD), the somatic-affective symptom cluster correlated significantly with depression in both patients with and patients without CAD. CONCLUSIONS:The association between depressive symptoms and atherosclerosis is explained by the somatic-affective symptom cluster of depression. Subclinical vascular disease thus may inflate depressive symptom scores and may explain why treatment of depression in cardiac patients hardly affects vascular outcome.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Bus BA,Marijnissen RM,Holewijn S,Franke B,Purandare N,de Graaf J,den Heijer M,Buitelaar JK,Voshaar RC

doi

10.1017/S0033291710002151

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

1419-28

issue

eissn

0033-2917

issn

1469-8978

pii

S0033291710002151

journal_volume

pub_type

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Depressive symptom clusters are differentially associated with atherosclerotic disease.