Abstract:
:Sixty surviving patients from a community-based stroke register who had CT scan evidence of a single brain lesion and neurological signs appropriate to it were interviewed three to five years following their first-ever stroke. Mood disorder (anxiety and depression), physical disability, and intellectual impairment were assessed using standardized measures. The position and volume of the brain lesion was determined from CT scans performed soon after the stroke. The prevalence of depressive disorder was lower in this sample than that reported in previous studies (DSM-IIIR major depression 8.3%; all DSM-IIIR depressive disorders 18.3%). Reports by other workers for an association of depressive disorder either with left-sided brain lesions, or with anteriorly placed lesions in the left cerebral hemisphere, were not supported. Neither was there evidence of a correlation between symptom score and proximity of the lesion to the anterior pole of the left cerebral hemisphere. Psychiatric symptom scores were however greater with larger volume brain lesions. Anxiety disorders, especially agoraphobia, were relatively common (20% if diagnosed in the presence of depressive disorder), but were not related to lesion location or volume.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Sharpe M,Hawton K,House A,Molyneux A,Sandercock P,Bamford J,Warlow Cdoi
10.1017/s0033291700036503subject
Has Abstractpub_date
1990-11-01 00:00:00pages
815-28issue
4eissn
0033-2917issn
1469-8978journal_volume
20pub_type
杂志文章abstract:BACKGROUND:UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001460
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Clinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as sty...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000361X
更新日期:2020-10-08 00:00:00
abstract:BACKGROUND:Agitated patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians differ in opinion and practice. In Lebanon, the use of the triple therapy haloperidol plus promethazine plus chlorpromazine (HPC) is frequently used but no studies involving t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004869
更新日期:2021-01-06 00:00:00
abstract::The validity of the twin method depends on the equal environment assumption (EEA)--that monozygotic (MZ) and dizygotic (DZ) twins are equally correlated in their exposure to environmental factors of aetiological importance for the trait under study. Parents may treat MZ twins more similarly than DZ twins thereby poten...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700027732
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Depression has been associated with abnormalities in neural underpinnings of Reward Learning (RL). However, inconsistencies have emerged, possibly owing to medication effects. Additionally, it remains unclear how neural RL signals relate to real-life behaviour. The current study, therefore, examined neural R...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003446
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:Studies evaluating depression's role in lung cancer risk revealed contradictory findings, partly because of the small number of cases, short follow-up periods, and failure to account for key covariates including smoking exposure. We investigated the association of depressive symptoms with lung cancer risk in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720004390
更新日期:2020-12-03 00:00:00
abstract::A cohort of 181 users of community psychiatric services in Camberwell with at least one year's history of contact was traced for two years following a census day. Four of the eight patients who had been given a primary diagnosis of an organic condition died during this period. For the others the population-standardize...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700051072
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:Meta-analyses link childhood trauma to depression, mania, anxiety disorders, and psychosis. It is unclear, however, whether these outcomes truly represent distinct disorders following childhood trauma, or that childhood trauma is associated with admixtures of affective, psychotic, anxiety and manic psychopat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714002372
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001976
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Studies suggest that alcohol consumption and alcohol use disorders have distinct genetic backgrounds. METHODS:We examined whether polygenic risk scores (PRS) for consumption and problem subscales of the Alcohol Use Disorders Identification Test (AUDIT-C, AUDIT-P) in the UK Biobank (UKB; N = 121 630) correla...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719004045
更新日期:2020-01-20 00:00:00
abstract:BACKGROUND:Life events and social problems are common in primary-care attenders and contribute to the high rate of emotional distress observed in this setting but are often not disclosed during the consultation. Physicians' characteristics associated with patients' disclosure of psychosocial problems are well documente...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291798007478
更新日期:1998-11-01 00:00:00
abstract::The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034838
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Morphometric endophenotypes which have been proposed for psychotic disorders include lateral ventricular enlargement and hippocampal volume reductions. Genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes have been implica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709990316
更新日期:2009-11-01 00:00:00
abstract::The age of onset in bipolar affective disorder was determined in 200 hospitalized patients. The mean age of their first affective syndrome was 28.3 years, and the mean age of first hospitalization was 30.8 years. However, the median age for first affective syndrome was 23 years (26 years for first hospitalization), an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003147
更新日期:1984-02-01 00:00:00
abstract::Neuropsychological tests of frontal lobe functions were undertaken in 46 chronic schizophrenic patients who were also rated for movement disorders. Tardive dyskinesia was found to have significant associations with most of these psychological tests. The possible mechanisms are discussed within the context of known neo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700032748
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Almost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-ana...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291716001562
更新日期:2016-10-01 00:00:00
abstract::This study aimed to investigate the psychological characteristics of chronic fatigue syndrome (CFS: Holmes et al. 1988). A battery of psychometric instruments comprising the General Health Questionnaire (GHQ), the Beck Depression Inventory (BDI), the Minnesota Multiphasic Personality Inventory (MMPI) and the Lazarus W...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700020456
更新日期:1991-05-01 00:00:00
abstract::The tests that have been used to assess glomerular and tubular function in patients receiving treatment with lithium have been reviewed. The advantages and disadvantages of these are discussed. The most useful tests are the creatinine clearance, which may be predicted from the serum creatinine using a formula or nomog...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:
更新日期:1985-05-01 00:00:00
abstract::Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...
journal_title:Psychological medicine
pub_type: 社论
doi:10.1017/S0033291716003123
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics. ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719004008
更新日期:2020-02-03 00:00:00
abstract:BACKGROUND:Many studies have reported an increased incidence of psychiatric disorder (particularly psychotic disorders) among first generation adult immigrants, along with an increasing risk for ethnic minorities living in low-minority concentration neighborhoods. These studies have depended mostly on European case-bas...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711000213
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Refugees commonly experience difficulties with emotional processing, such as alexithymia, due to stressful or traumatic experiences. However, the functional connectivity of the amygdala, which is central to emotional processing, has yet to be assessed in refugees. Thus, the present study investigated the res...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000175
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Studies investigating neurocognitive impairment in subjects with eating disorders (EDs) have reported heterogeneous patterns of impairment and, in some instances, no dysfunction. The present study aimed to define the pattern of neurocognitive impairment in a large sample of bulimia nervosa (BN) patients and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710001303
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Compassion-focused therapy (CFT) is a relatively novel form of psychotherapy that was developed for people who have mental health problems primarily linked to high shame and self-criticism. The aim of this early systematic review was to draw together the current research evidence of the effectiveness of CFT ...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291714002141
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:There are no risk models for the prediction of anxiety that may help in prevention. We aimed to develop a risk algorithm for the onset of generalized anxiety and panic syndromes. METHOD:Family practice attendees were recruited between April 2003 and February 2005 and followed over 24 months in the UK, Spain...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002400
更新日期:2011-08-01 00:00:00
abstract:BACKGROUND:Although positive effects of physical activity on mental health indicators have been reported, the relationship between physical activity and the development of specific mental disorders is unclear. METHOD:A cross-sectional (12-month) and prospective-longitudinal epidemiological study over 4 years in a comm...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170700089X
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Generalized anxiety disorder is a common condition of excessive worry and tension which tends to run a chronic course associated with significant psychiatric and medical problems. Cognitive behaviour therapy (CBT) has been shown to be of clinical value in about 50% of cases with treatment gains maintained ov...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291702007079
更新日期:2003-04-01 00:00:00
abstract:BACKGROUND:Cognitive models propose that auditory verbal hallucinations arise through defective self-monitoring and external attribution of inner speech. We used a paradigm that engages verbal self-monitoring to examine how deficits in this process are related to symptoms and diagnosis in patients with psychosis. METH...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705006628
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:Previous research has yielded conflicting evidence regarding the long-term cognitive outcome of depression. Some studies have found evidence for a higher incidence of subsequent cognitive impairment or dementia, while others have refuted this. METHOD:Depression, neuropsychological performance, functional ab...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008195
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Three prior population-based twin studies, none of which was nationally representative, suggested that both genetic and familial-environmental factors contribute to family resemblance for lifetime cannabis use. We seek to replicate these results in a US national probability sample of twin and sibling pairs e...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004950
更新日期:2002-04-01 00:00:00