Abstract:
BACKGROUND:Aberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown. METHOD:Here, we systematically investigated default network connectivity in 15 OCD patients, 15 paired unaffected siblings and 28 healthy controls. We sought to examine the profiles of default network connectivity in OCD patients and their siblings, exploring the correlation between abnormal default network connectivity and genetic risk for this population. RESULTS:Compared with healthy controls, OCD patients exhibited reduced strength of default network functional connectivity with the posterior cingulate cortex (PCC), and increased functional connectivity in the right inferior frontal lobe, insula, superior parietal cortex and superior temporal cortex, while their unaffected first-degree siblings only showed reduced local connectivity in the PCC. CONCLUSIONS:These findings suggest that the disruptions of default network functional connectivity might be associated with family history of OCD. The decreased default network connectivity in both OCD patients and their unaffected siblings may serve as a potential marker of OCD.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Peng ZW,Xu T,He QH,Shi CZ,Wei Z,Miao GD,Jing J,Lim KO,Zuo XN,Chan RCdoi
10.1017/S0033291713002250subject
Has Abstractpub_date
2014-05-01 00:00:00pages
1475-84issue
7eissn
0033-2917issn
1469-8978pii
S0033291713002250journal_volume
44pub_type
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