Default network connectivity as a vulnerability marker for obsessive compulsive disorder.

Abstract:

BACKGROUND:Aberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown. METHOD:Here, we systematically investigated default network connectivity in 15 OCD patients, 15 paired unaffected siblings and 28 healthy controls. We sought to examine the profiles of default network connectivity in OCD patients and their siblings, exploring the correlation between abnormal default network connectivity and genetic risk for this population. RESULTS:Compared with healthy controls, OCD patients exhibited reduced strength of default network functional connectivity with the posterior cingulate cortex (PCC), and increased functional connectivity in the right inferior frontal lobe, insula, superior parietal cortex and superior temporal cortex, while their unaffected first-degree siblings only showed reduced local connectivity in the PCC. CONCLUSIONS:These findings suggest that the disruptions of default network functional connectivity might be associated with family history of OCD. The decreased default network connectivity in both OCD patients and their unaffected siblings may serve as a potential marker of OCD.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Peng ZW,Xu T,He QH,Shi CZ,Wei Z,Miao GD,Jing J,Lim KO,Zuo XN,Chan RC

doi

10.1017/S0033291713002250

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

1475-84

issue

7

eissn

0033-2917

issn

1469-8978

pii

S0033291713002250

journal_volume

44

pub_type

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