Abstract:
:Thirty-eight boys, referred for psychiatric treatment because of serious problems of behaviour, underwent a double-blind, placebo-controlled, crossover trial of methylphenidate and placebo. Methylphenidate was an effective treatment over a 3-week period. A good response to methylphenidate was predicted by higher levels of inattentive and restless behaviour, impaired performance on tests of attention, clumsiness, younger age and by the absence of symptoms of overt emotional disorder. DSM-III and ICD-9 diagnoses of 'hyperactivity' were not good predictors. The results support the validity of a construct of hyperactivity in describing childhood psychopathology, but emphasize the need for a refinement of diagnostic criteria.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Taylor E,Schachar R,Thorley G,Wieselberg HM,Everitt B,Rutter Mdoi
10.1017/s0033291700013039subject
Has Abstractpub_date
1987-02-01 00:00:00pages
121-43issue
1eissn
0033-2917issn
1469-8978journal_volume
17pub_type
临床试验,杂志文章abstract:BACKGROUND:Although psychiatric patients with eating disorders are known to be at risk for a variety of health problems, relatively little is known about eating disorders and associated health problems in other populations. An epidemiological study was conducted to investigate health problems and impairment associated ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/s0033291701004640
更新日期:2001-11-01 00:00:00
abstract:BACKGROUND:Almost nothing is known about the potential negative effects of Internet-based psychological treatments for depression. This study aims at investigating deterioration and its moderators within randomized trials on Internet-based guided self-help for adult depression, using an individual patient data meta-ana...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291716001562
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:The diagnosis of bipolar disorder in pre-pubertal populations remains difficult and often controversial. Consequently, the clinical and neuropsychological characteristics of mania in the child and adolescent years remain poorly defined. This review provides a clinical account of childhood and adolescent bipo...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291706007446
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Cognitive impairment and negative symptoms are two of the primary features of schizophrenia associated with poor social functioning. We examined the relationships between clinical characteristics, specific cognitive abilities and social skills performance in middle-aged and older out-patients with schizophre...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001304
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate a programme of lesion surgery carried out on patients with treatment-resistant depression (TRD). METHOD:This was a retrospective study looking at clinical and psychometric data from 45 patients with TRD who had undergone bilateral stereotactic anterior capsulotomy s...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716003159
更新日期:2017-04-01 00:00:00
abstract::Functional and phenotypic immunological parameters were examined immediately before, after, and 30 minutes after experimentally-induced short-term positive (happiness) and negative (anxiety, depression) affective states and a neutral state, in five healthy subjects. Results indicated that all affective states induced ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170003289x
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date. METHOD:We conducted a first-episode follow-up study of 97 patients with DSM-IV schizop...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170800336X
更新日期:2008-08-01 00:00:00
abstract::Diffuse loss of cortical volume and ventricular enlargement have been demonstrated in schizophrenia using imaging. In addition, histological studies have provided evidence that the number of neurons in the medial temporal lobe structures is reduced and that the cytoarchitecture is abnormal. In an attempt to correlate ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700033171
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological pathways. Of candidate biological pathways for schizophrenia (SZ), the cell adhesion molecule (CAM...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713002663
更新日期:2014-07-01 00:00:00
abstract::Hypothalamic-pituitary-adrenal axis function was investigated in 72 patients with primary depression. Forty-four per cent of the patients demonstrated abnormal suppression of their cortisol levels after a 1 mg overnight dexamethasone suppression test. Patients with abnormal suppression ('non-suppressors') were not cle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700019711
更新日期:1984-11-01 00:00:00
abstract::A community survey of psychiatric disorder carried out in South London enabled the authors to investigate the 'vulnerability model' proposed by Brown & Harris (1978). In the current study none of the 'vulnerability factors' proposed by Brown & Harris fulfilled the requirements of the model. It was, however, found that...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003603
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:The relationship between white-matter tracts and executive functions (EF) in attention deficit hyperactivity disorder (ADHD) has not been well studied and previous studies mainly focused on frontostriatal (FS) tracts. The authors explored the microstructural property of several fibre tracts hypothesized to b...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002767
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND:Counselling is frequently used in the management of common mental disorders (such as anxiety and depression) in primary care. However, there are concerns over the clinical effectiveness of counselling, both in comparison with usual general practitioner care, and with other treatments such as alternative psyc...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/s0033291702006979
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:High expressed emotion (EE) in families reliably predicts relapse in schizophrenia leading to the assumption that high EE stresses patients and is the cause of relapse. Attempts at validating the stressful properties of high EE using autonomic skin conductance measures have been inconclusive. Since memory lo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002718
更新日期:2000-09-01 00:00:00
abstract:BACKGROUND:Differences between verbal and non-verbal cognitive development from childhood to adulthood may differentiate between those with and without psychotic symptoms and affective symptoms in later life. However, there has been no study exploring this in a population-based cohort. METHOD:The sample was drawn from...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000393
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:The association between cigarette smoking and psychosis remains unexplained, but could relate to causal effects in both directions, confounding by socioeconomic factors, such as ethnicity, or use of other substances, including cannabis. Few studies have evaluated the association between cigarettes and psycho...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717001556
更新日期:2018-01-01 00:00:00
abstract::One week after Sir William Gull read his seminal report on anorexia nervosa to the Clinical Society of London, a brief account was published (Anonymous, 1873). In Paris, Charles Lasègue, editor of Archives Générales de Médecine read the report and printed an immediate editorial riposte, parts of which will be quoted i...
journal_title:Psychological medicine
pub_type: 传,历史文章,杂志文章
doi:10.1017/s0033291700030245
更新日期:1992-05-01 00:00:00
abstract::A monotonous voice is produced by schizophrenic patients whose expression of emotion is damped down and by patients with a severe degree of depression. Clinically, the distinction between these two diagnostic entities is virtually impossible to establish auditorily on the basis of voice quality alone. The laryngograph...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700041349
更新日期:1981-11-01 00:00:00
abstract::In this paper four principal topics are addressed: (a) the policy and political contexts in which demands arise for cost information; (b) the nature and phasing of those demands; (c) the basic rules of empirical costs research for meeting those demands; and (d) concomitant implications for the design, execution and in...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s003329170003659x
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Psychological traumatic events, such as war or road traffic accidents, are widespread. A small but significant proportion of survivors develop post-traumatic stress disorder (PTSD). Distressing, sensory-based involuntary memories of trauma (henceforth 'flashbacks') are the hallmark symptom of PTSD. Understan...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712002358
更新日期:2013-07-01 00:00:00
abstract::Five hundred and eighty schoolgirls living in a small North Indian industrial town were screened using the EAT-26. Although twenty-nine per cent scored above the threshold for the questionnaire (greater than or equal to 20), closer scrutiny of the pattern of responses revealed misinterpretations of a large number of q...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005675
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Neuroticism has been shown to increase the risk of depression whereas extraversion is associated with a reduction of risk. These personality traits play a central role in aetiological theories of affective disorder but their role in schizophrenia is unclear. In this study, the risk for schizophrenia associat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004044
更新日期:2001-08-01 00:00:00
abstract::An entire population of 32 patients on regular dialysis treatment (RDT) in their own homes were ranked according to their present mental state as assessed by a standardized semi-structured interview. The point-prevalence of psychiatric morbidity was 31% which compares closely with that of patients attending a general ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700032062
更新日期:1979-08-01 00:00:00
abstract:BACKGROUND:A series of research reports has indicated that the use of substances such as cannabis, alcohol and tobacco are higher in youth at clinical high risk (CHR) of developing psychosis than in controls. Little is known about the longitudinal trajectory of substance use, and findings on the relationship between su...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291715000227
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Although specific phobia is highly prevalent, associated with impairment, and an important risk factor for the development of other mental disorders, cross-national epidemiological data are scarce, especially from low- and middle-income countries. This paper presents epidemiological data from 22 low-, lower-...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717000174
更新日期:2017-07-01 00:00:00
abstract::This paper presents the results of a study of unemployment among British Asians living in the north of England. The sample comprises 139 employed and unemployed men. Using standardized psychological questionnaires with a semi-structured interview schedule, the psychological consequences of unemployment are examined in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170002732x
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Seeking compensation has been shown to have an adverse effect on the psychological health and recovery of injured patients, however, this effect requires clarification. METHODS:A total of 2019 adults sustaining a traffic injury were recruited. Of these, 709 (35.1%) lodged a compensation claim. Interviews oc...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000166X
更新日期:2020-06-09 00:00:00
abstract:BACKGROUND:Depressive symptoms above screening thresholds have been shown to predict functional decline in older adults. Less is known about the impact of subthreshold depression, and whether more symptoms confer significantly greater risk compared to fewer symptoms. METHOD:Using data from the Duke Established Populat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709005650
更新日期:2009-10-01 00:00:00
abstract::In an earlier paper we found that a model of depression developed on a sample of women in a London population was confirmed in a female population in the Outer Hebrides. Differences in the rates of onset and chronic cases between the two populations, however, suggested that the Scottish women might be more likely to b...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700052892
更新日期:1981-08-01 00:00:00
abstract::A standardized pegboard task was used to investigate changes in manipulative skill as a function of age in 119 right-handed subjects. The typical pattern of cognitive impairment in old age indicates a relative preservation of functions which depend on the integrity of the left hemisphere. In accord with these observat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700005109
更新日期:1985-11-01 00:00:00