Clinical and neuropsychological characteristics of child and adolescent bipolar disorder.

Abstract:

BACKGROUND:The diagnosis of bipolar disorder in pre-pubertal populations remains difficult and often controversial. Consequently, the clinical and neuropsychological characteristics of mania in the child and adolescent years remain poorly defined. This review provides a clinical account of childhood and adolescent bipolar disorder and compares the neuropsychology and neuroanatomy of young BPD patients compared with adult BPD and childhood syndromes of attention deficit hyperactivity disorder (ADHD) and conduct disorder (CD). METHOD:Literature review based on Pubmed searches. RESULTS:Early- and adult-onset mania and BPD may share a common pattern of neurobiological characteristics despite developmental variations in the clinical presentation. In contrast, important distinctions are apparent between the child-onset syndromes of BPD, ADHD and CD, specifically at the neural level. CONCLUSIONS:Disorders of affect dysregulation in childhood deserve closer neuroscientific and phenotypic scrutiny than given hitherto.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Kyte ZA,Carlson GA,Goodyer IM

doi

10.1017/S0033291706007446

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

1197-211

issue

9

eissn

0033-2917

issn

1469-8978

pii

S0033291706007446

journal_volume

36

pub_type

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