The neural basis of consciousness.

Abstract:

:Consciousness has evolved and is a feature of all animals with sufficiently complex nervous systems. It is, therefore, primarily a problem for biology, rather than physics. In this review, I will consider three aspects of consciousness: level of consciousness, whether we are awake or in a coma; the contents of consciousness, what determines how a small amount of sensory information is associated with subjective experience, while the rest is not; and meta-consciousness, the ability to reflect upon our subjective experiences and, importantly, to share them with others. I will discuss and compare current theories of the neural and cognitive mechanisms involved in producing these three aspects of consciousness and conclude that the research in this area is flourishing and has already succeeded to delineate these mechanisms in surprising detail.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Frith CD

doi

10.1017/S0033291719002204

subject

Has Abstract

pub_date

2019-09-04 00:00:00

pages

1-13

eissn

0033-2917

issn

1469-8978

pii

S0033291719002204

pub_type

杂志文章
  • Differential neural reward mechanisms in treatment-responsive and treatment-resistant schizophrenia.

    abstract:BACKGROUND:The significant proportion of schizophrenia patients refractory to treatment, primarily directed at the dopamine system, suggests that multiple mechanisms may underlie psychotic symptoms. Reinforcement learning tasks have been employed in schizophrenia to assess dopaminergic functioning and reward processing...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718000041

    authors: Vanes LD,Mouchlianitis E,Collier T,Averbeck BB,Shergill SS

    更新日期:2018-10-01 00:00:00

  • Prevalence and determinants of cognitive impairment in the euthymic phase of bipolar disorders: results from the FACE-BD cohort.

    abstract:BACKGROUND:Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001186

    authors: Roux P,Etain B,Cannavo AS,Aubin V,Aouizerate B,Azorin JM,Bellivier F,Belzeaux R,Bougerol T,Cussac I,Courtet P,Kahn JP,Leboyer M,M'Bailara K,Payet MP,Olié E,FondaMental Advanced Centers of Expertise in Bipolar Disorders (F

    更新日期:2019-02-01 00:00:00

  • Estimating the incidence of first-episode psychosis using population-based health administrative data to inform early psychosis intervention services.

    abstract:BACKGROUND:Discrepancies between population-based estimates of the incidence of psychotic disorder and the treated incidence reported by early psychosis intervention (EPI) programs suggest additional cases may be receiving services elsewhere in the health system. Our objective was to estimate the incidence of non-affec...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718002933

    authors: Anderson KK,Norman R,MacDougall AG,Edwards J,Palaniyappan L,Lau C,Kurdyak P

    更新日期:2019-09-01 00:00:00

  • The impact of unemployment on the psychological well-being of British Asians.

    abstract::This paper presents the results of a study of unemployment among British Asians living in the north of England. The sample comprises 139 employed and unemployed men. Using standardized psychological questionnaires with a semi-structured interview schedule, the psychological consequences of unemployment are examined in...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170002732x

    authors: Shams M,Jackson PR

    更新日期:1994-05-01 00:00:00

  • A comparison of the clinical characteristics of women with recurrent major depression with and without suicidal symptomatology.

    abstract:BACKGROUND:The relationship between recurrent major depression (MD) in women and suicidality is complex. We investigated the extent to which patients who suffered with various forms of suicidal symptomatology can be distinguished from those subjects without such symptoms. METHOD:We examined the clinical features of th...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171200058X

    authors: Bi B,Xiao X,Zhang H,Gao J,Tao M,Niu H,Wang Y,Wang Q,Chen C,Sun N,Li K,Fu J,Gan Z,Sang W,Zhang G,Yang L,Tian T,Li Q,Yang Q,Sun L,Li Y,Rong H,Guan C,Zhao X,Ye D,Zhang Y,Ma Z,Li H,He K,Chen J,Cai

    更新日期:2012-12-01 00:00:00

  • The set-shifting profiles of anorexia nervosa and autism spectrum disorder using the Wisconsin Card Sorting Test: a systematic review and meta-analysis.

    abstract::Difficulties in set-shifting are commonly reported in both autism spectrum disorder (ASD) and anorexia nervosa (AN) populations. Despite this, it is not known whether this cognitive profile persists across different ages, or whether the profiles seen in ASD and AN are comparable. This systematic review and meta-analys...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291716000581

    authors: Westwood H,Stahl D,Mandy W,Tchanturia K

    更新日期:2016-07-01 00:00:00

  • Slow binocular rivalry in bipolar disorder.

    abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703007475

    authors: Miller SM,Gynther BD,Heslop KR,Liu GB,Mitchell PB,Ngo TT,Pettigrew JD,Geffen LB

    更新日期:2003-05-01 00:00:00

  • Abnormal response to metabolic stress in schizophrenia: marker of vulnerability or acquired sensitization?

    abstract:BACKGROUND:Previous work suggests that individuals with schizophrenia display an altered homovanillic acid (HVA) response to metabolic stress. The present study replicated and extended this paradigm, including individuals with elevated genetic risk for schizophrenia. METHOD:Patients with psychosis (n = 50), non-psycho...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291703001715

    authors: Marcelis M,Cavalier E,Gielen J,Delespaul P,Van Os J

    更新日期:2004-08-01 00:00:00

  • Feedback learning and behavior problems after pediatric traumatic brain injury.

    abstract:BACKGROUND:Feedback learning is essential for behavioral development. We investigated feedback learning in relation to behavior problems after pediatric traumatic brain injury (TBI). METHOD:Children aged 6-13 years diagnosed with TBI (n = 112; 1.7 years post-injury) were compared with children with traumatic control (...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716000106

    authors: Königs M,van Heurn LW,Vermeulen RJ,Goslings JC,Luitse JS,Poll-Thé BT,Beelen A,van der Wees M,Kemps RJ,Catsman-Berrevoets CE,Luman M,Oosterlaan J

    更新日期:2016-05-01 00:00:00

  • Prevalence of cavum septum pellucidum detected by MRI in patients with bipolar disorder, major depression and schizophrenia.

    abstract::The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700034838

    authors: Shioiri T,Oshitani Y,Kato T,Murashita J,Hamakawa H,Inubushi T,Nagata T,Takahashi S

    更新日期:1996-03-01 00:00:00

  • Associations between mood instability and emotional processing in a large cohort of bipolar patients.

    abstract:BACKGROUND:Aberrant emotional biases have been reported in bipolar disorder (BD), but results are inconsistent. Despite the clinical relevance of chronic mood variability in BD, there is no previous research investigating how the extent of symptom fluctuations in bipolar disorder might relate to emotional biases. This ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171600180X

    authors: Bilderbeck AC,Reed ZE,McMahon HC,Atkinson LZ,Price J,Geddes JR,Goodwin GM,Harmer CJ

    更新日期:2016-11-01 00:00:00

  • Inhibitory deficits for negative information in persons with major depressive disorder.

    abstract:BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707000530

    authors: Lau MA,Christensen BK,Hawley LL,Gemar MS,Segal ZV

    更新日期:2007-09-01 00:00:00

  • Episodic memory in depression: the unique contribution of the anterior caudate and hippocampus.

    abstract:BACKGROUND:Learning and memory impairments in older adults with depression are linked to hippocampal atrophy. However, other subcortical regions may also be contributing to these deficits. We aimed to examine whether anterior caudate nucleus volume is significantly reduced in older adults with depression compared to co...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716000787

    authors: Jayaweera HK,Hickie IB,Duffy SL,Mowszowski L,Norrie L,Lagopoulos J,Naismith SL

    更新日期:2016-07-01 00:00:00

  • Long-stay patients in Danish psychiatric hospitals.

    abstract::The numbers of long-stay patients in Danish psychiatric hospitals were studied, based on information from the Danish cumulative psychiatric register and from the census studies of patients in Danish psychiatric hospitals, performed at 5-year intervals since 1957. In 1977, 2079 (20%) of the in-patient population which ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700032116

    authors: Weeke A,Kastrup M,Dupont A

    更新日期:1979-08-01 00:00:00

  • Amygdala-prefrontal connectivity during appraisal of symptom-related stimuli in obsessive-compulsive disorder.

    abstract:BACKGROUND:Cognitive models of obsessive-compulsive disorder (OCD) posit dysfunctional appraisal of disorder-relevant stimuli in patients, suggesting disturbances in the processes relying on amygdala-prefrontal connectivity. Recent neuroanatomical models add to the traditional view of dysfunction in corticostriatal cir...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171800079X

    authors: Paul S,Beucke JC,Kaufmann C,Mersov A,Heinzel S,Kathmann N,Simon D

    更新日期:2019-01-01 00:00:00

  • Changes in resting-state brain networks after cognitive-behavioral therapy for chronic pain.

    abstract:BACKGROUND:Cognitive-behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of the latter being closely associated with cognitive-emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used the independent component analysis m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717002598

    authors: Yoshino A,Okamoto Y,Okada G,Takamura M,Ichikawa N,Shibasaki C,Yokoyama S,Doi M,Jinnin R,Yamashita H,Horikoshi M,Yamawaki S

    更新日期:2018-05-01 00:00:00

  • Predicting depression outcomes throughout inpatient treatment using the general and specific personality disorder factors.

    abstract:BACKGROUND:Clinical intuition suggests that personality disorders hinder the treatment of depression, but research findings are mixed. One reason for this might be the way in which current assessment measures conflate general aspects of personality disorders, such as overall severity, with specific aspects, such as sty...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329172000361X

    authors: Constantinou MP,Frueh BC,Fowler JC,Allen JG,Madan A,Oldham JM,Fonagy P

    更新日期:2020-10-08 00:00:00

  • Information processing deficits in relatives of manic depressive patients.

    abstract:BACKGROUND:The importance of genetic factors in the aetiology of manic-depressive illness (MDI) has been repeatedly confirmed and indicators of vulnerability to the illness in families with affective disorders are needed. Abnormal event-related potentials (ERP) may be markers of genetic vulnerability to mental illness....

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799001944

    authors: Pierson A,Jouvent R,Quintin P,Perez-Diaz F,Leboyer M

    更新日期:2000-05-01 00:00:00

  • Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

    abstract:BACKGROUND:There is evidence that patients with chronic fatigue syndrome (CFS) have mild hypocortisolism. The clinical significance of this is unclear. We aimed to determine whether hypocortisolism exerted any effect on the response of CFS to cognitive behavioural therapy (CBT). METHOD:We measured 24-h urinary free co...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709990390

    authors: Roberts AD,Charler ML,Papadopoulos A,Wessely S,Chalder T,Cleare AJ

    更新日期:2010-03-01 00:00:00

  • Expressed emotion research in schizophrenia: theoretical and clinical implications.

    abstract::The expressed emotion (EE) measure is a robust predictor of relapse in schizophrenia. At least twelve studies from a range of cultures have now shown this, although the authors of one maintain their findings are the result of confounding factors. A thirteenth study which failed to demonstrate a predictive effect was s...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700009831

    authors: Kuipers L,Bebbington P

    更新日期:1988-11-01 00:00:00

  • Cohabitation patterns among patients with severe psychiatric disorders in the entire Danish population.

    abstract:BACKGROUND:Assortative mating has been demonstrated in mental disorders but the extent of cohabitation between patients with clinically diagnosed psychiatric disease has been poorly explored. Method We conducted a register-based study of all Danes between 18 and 70 years of age in a 13-year observational period, linkin...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171200181X

    authors: Thomsen AF,Olsbjerg M,Andersen PK,Kessing LV

    更新日期:2013-05-01 00:00:00

  • Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis.

    abstract:BACKGROUND:Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not associated with suicidality. The PHQ-8, which omits Item 9, is thus increasingly used in research. We ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719001314

    authors: Wu Y,Levis B,Riehm KE,Saadat N,Levis AW,Azar M,Rice DB,Boruff J,Cuijpers P,Gilbody S,Ioannidis JPA,Kloda LA,McMillan D,Patten SB,Shrier I,Ziegelstein RC,Akena DH,Arroll B,Ayalon L,Baradaran HR,Baron M,Bombardier

    更新日期:2020-06-01 00:00:00

  • DSM-IV post-traumatic stress disorder among World Trade Center responders 11-13 years after the disaster of 11 September 2001 (9/11).

    abstract:BACKGROUND:Post-traumatic symptomatology is one of the signature effects of the pernicious exposures endured by responders to the World Trade Center (WTC) disaster of 11 September 2001 (9/11), but the long-term extent of diagnosed Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) post-traumati...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715002184

    authors: Bromet EJ,Hobbs MJ,Clouston SA,Gonzalez A,Kotov R,Luft BJ

    更新日期:2016-03-01 00:00:00

  • Familial confounding of the association between maternal smoking during pregnancy and internalizing disorders in offspring.

    abstract:BACKGROUND:Maternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation. METHOD...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716003627

    authors: Meier SM,Plessen KJ,Verhulst F,Mors O,Mortensen PB,Pedersen CB,Agerbo E

    更新日期:2017-01-19 00:00:00

  • The expressed emotion of case managers of the seriously mentally ill: the influence of expressed emotion on clinical outcomes.

    abstract:BACKGROUND:Expressed emotion (EE) measured from relatives and informal carers has been consistently demonstrated to be associated with clinical outcome in schizophrenic patients. There have also been published studies that have investigated EE in professional carers that have suggested that the quality of the relations...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799001579

    authors: Tattan T,Tarrier N

    更新日期:2000-01-01 00:00:00

  • The seasonal incidence of mania and its relationship to climatic variables.

    abstract::Monthly hospital admission rates (HA) for mania were classified by sex, type of admission (first, or re-admission) and by country (England and Wales or Scotland). Of the 8 classes thus created, all but one showed a statistically significant annual cycle with a peak in Summer and trough in Winter. There was no signific...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001610x

    authors: Myers DH,Davies P

    更新日期:1978-08-01 00:00:00

  • Pituitary volume and clinical trajectory in young relatives at risk for schizophrenia.

    abstract:BACKGROUND:Stress and vulnerability likely interact to play a major role in psychosis. While much has been written about the neural diathesis-stress model in psychosis and its clinical risk states, little is known about HPA axis biomarkers in non-help-seeking individuals at familial high risk (FHR). We sought to prospe...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329171500077X

    authors: Shah JL,Tandon N,Howard ER,Mermon D,Miewald JM,Montrose DM,Keshavan MS

    更新日期:2015-10-01 00:00:00

  • Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder.

    abstract:BACKGROUND:The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of othe...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717002288

    authors: Cano M,Alonso P,Martínez-Zalacaín I,Subirà M,Real E,Segalàs C,Pujol J,Cardoner N,Menchón JM,Soriano-Mas C

    更新日期:2018-04-01 00:00:00

  • A reappraisal of alcoholic psychoses.

    abstract::A retrospective study of alcoholic psychoses is reported. The phenomena of the illnesses corresponded poorly with classical descriptions of alcoholic hallucinosis, delirium tremens and alcoholic paranoia. Alternative diagnostic approaches were tried (Catego, restrictive definition of alcoholic hallucinosis). The probl...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700014331

    authors: Cutting J

    更新日期:1978-05-01 00:00:00

  • Group transdiagnostic cognitive-behavior therapy for anxiety disorders: a pragmatic randomized clinical trial.

    abstract:BACKGROUND:Transdiagnostic group cognitive-behavioral therapy (tCBT) is a delivery model that could help overcome barriers to large-scale implementation of evidence-based psychotherapy for anxiety disorders. The aim of this study was to assess the effectiveness of combining group tCBT with treatment-as-usual (TAU), com...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004316

    authors: Roberge P,Provencher MD,Gaboury I,Gosselin P,Vasiliadis HM,Benoît A,Carrier N,Antony MM,Chaillet N,Houle J,Hudon C,Norton PJ

    更新日期:2020-12-02 00:00:00