Smooth pursuit deficits in schizophrenia, affective disorder and obsessive-compulsive disorder.

Abstract:

BACKGROUND:In schizophrenia, affective disorders, and obsessive-compulsive disorder (OCD) dysfunction of frontal neuronal circuits has been suggested. Such impairments imply corresponding oculomotor deficits. METHOD:Eye movement response to foveofugal and foveopetal step-ramp stimuli was recorded within the same study design in patients with schizophrenia (N= 16), affective disorder (N= 15), and OCD (N= 18) and compared with controls (N=23) using infra-red reflection oculography. RESULTS:In the foveofugal task steady-state velocity was lower in all patient groups compared with controls. Post-saccadic eye velocity was also decreased in patients with schizophrenia and affective disorder. In the foveopetal stimulus steady-state velocity was reduced in schizophrenic patients, only. Changes of saccadic latencies or position errors were not found in any of the patient groups. Also, pursuit latency was unchanged and initial eye acceleration was not decreased. CONCLUSIONS:Unaltered saccadic parameters indicate intact motion perception in cortical visual area V5. Therefore, the observed deficit of pursuit maintenance implies a dysfunction of frontal networks in all patient groups including the pursuit region of the frontal eye field (FEF). In patients with schizophrenia and affective disorder reduced post-saccadic pursuit initiation may indicate an impaired interaction between the pursuit and the saccadic system.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Lencer R,Trillenberg P,Trillenberg-Krecker K,Junghanns K,Kordon A,Broocks A,Hohagen F,Heide W,Arolt V

doi

10.1017/s0033291703001314

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

451-60

issue

3

eissn

0033-2917

issn

1469-8978

journal_volume

34

pub_type

杂志文章
  • Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action.

    abstract::Twenty-three acute psychotic patients who were drug free at the time of testing performed a motor task designed to elicit many errors. Normal subjects and many of the psychotic patients were able to correct these errors in the absence of visual feedback. The ability to make such corrections depends on the subject know...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001240x

    authors: Frith CD,Done DJ

    更新日期:1989-05-01 00:00:00

  • Ageing in people with Prader-Willi syndrome: mortality in the UK population cohort and morbidity in an older sample of adults.

    abstract:BACKGROUND:The past two decades have seen a great improvement in the care of people with Prader-Willi syndrome (PWS), particularly with regard to control of diet and behaviour management. Has this affected mortality rates or thrown up new issues regarding premature ageing or dementia? We investigated two aspects of age...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291714001755

    authors: Whittington JE,Holland AJ,Webb T

    更新日期:2015-02-01 00:00:00

  • Symptom-specific self-referential cognitive processes in bipolar disorder: a longitudinal analysis.

    abstract:BACKGROUND:Although depression and mania are often assumed to be polar opposites, studies have shown that, in patients with bipolar disorder, they are weakly positively correlated and vary somewhat independently over time. Thus, when investigating relationships between specific psychological processes and specific symp...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291712002711

    authors: Pavlickova H,Varese F,Turnbull O,Scott J,Morriss R,Kinderman P,Paykel E,Bentall RP

    更新日期:2013-09-01 00:00:00

  • History of childhood sexual or physical abuse in Japanese patients with eating disorders: relationship with dissociation and impulsive behaviours.

    abstract:BACKGROUND:Empirical data regarding prevalence of sexual and physical abuse histories in Japanese patients with eating disorders is lacking, in contrast to Western countries. This study investigated the prevalence of traumatic events in Japanese patients with eating disorders, and examined the relationship between such...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799008557

    authors: Nagata T,Kiriike N,Iketani T,Kawarada Y,Tanaka H

    更新日期:1999-07-01 00:00:00

  • Cognitive remediation improves memory and psychosocial functioning in first-episode psychiatric out-patients.

    abstract:BACKGROUND:Cognitive remediation (CR) is an effective treatment for several psychiatric disorders. To date, there have been no published studies examining solely first-episode psychiatric cohorts, despite the merits demonstrated by early intervention CR studies. The current study aimed to assess the effectiveness of CR...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291712002127

    authors: Lee RS,Redoblado-Hodge MA,Naismith SL,Hermens DF,Porter MA,Hickie IB

    更新日期:2013-06-01 00:00:00

  • Parental representations of melancholic and non-melancholic depressives: examining for specificity to depressive type and for evidence of additive effects.

    abstract::Several studies have suggested that 'anomalous parenting', as measured by the Parental Bonding Instrument (PBI), may be a differential risk factor to subsequent depression in adulthood--being irrelevant to melancholia but over-represented in non-melancholic depressive disorders. Such a 'specificity' effect is confirme...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700038101

    authors: Parker G,Hadzi-Pavlovic D

    更新日期:1992-08-01 00:00:00

  • Altered functional connectivity of the subthalamus and the bed nucleus of the stria terminalis in obsessive-compulsive disorder.

    abstract:BACKGROUND:The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of othe...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717002288

    authors: Cano M,Alonso P,Martínez-Zalacaín I,Subirà M,Real E,Segalàs C,Pujol J,Cardoner N,Menchón JM,Soriano-Mas C

    更新日期:2018-04-01 00:00:00

  • Domiciliary and out-patient treatment of self-poisoning patients by medical and non-medical staff.

    abstract::In a study of domiciliary and out-patient treatment of self-poisoning patients, using a brief problem-orientated approach, it was found that domiciliary treatment resulted in much higher attendance rates but no difference in outcome. Patients who completed out-patient treatment had a better outcome than those who fail...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700053381

    authors: Hawton K,Bancroft J,Catalan J,Kingston B,Stedeford A,Welch N

    更新日期:1981-02-01 00:00:00

  • Abnormal diurnal weight gain among chronically psychotic patients contrasted with acutely psychotic patients and normals.

    abstract::We found diurnal weight gain to be abnormal among 28 institutionalized chronically psychotic patients. They were weighed daily for 15 days at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and th...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700011065

    authors: Vieweg WV,Godleski LS,Mitchell M,Hundley PL,Yank GR

    更新日期:1989-02-01 00:00:00

  • Individual differences in rumination in healthy and depressive samples: association with brain structure, functional connectivity and depression.

    abstract:BACKGROUND:Rumination is an important cognitive risk factor for onset and relapse of depression. However, no studies have employed a dimensional approach in investigating the neural correlates of rumination and the relationship with depression. METHOD:Non-clinical healthy subjects (n = 306), who completed the classica...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715000938

    authors: Wang K,Wei D,Yang J,Xie P,Hao X,Qiu J

    更新日期:2015-10-01 00:00:00

  • Concordance in the mental health of spouses: analysis of a large national household panel survey.

    abstract:BACKGROUND:Spousal concordance for common mental disorders provides evidence of the relevance of social contextual factors. There are, however, limitations within the existing literature examining spousal similarity in mental health and little consensus as to the causes of spousal similarity. This study considers a lar...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291705006677

    authors: Butterworth P,Rodgers B

    更新日期:2006-05-01 00:00:00

  • Negative bias in fast emotion discrimination in borderline personality disorder.

    abstract:BACKGROUND:The ability to decode emotional information from facial expressions is crucial for successful social interaction. Borderline personality disorder (BPD) is characterized by serious problems in interpersonal relationships and emotional functioning. Empirical research on facial emotion recognition in BPD has be...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708004273

    authors: Dyck M,Habel U,Slodczyk J,Schlummer J,Backes V,Schneider F,Reske M

    更新日期:2009-05-01 00:00:00

  • Manual-assisted cognitive-behaviour therapy (MACT): a randomized controlled trial of a brief intervention with bibliotherapy in the treatment of recurrent deliberate self-harm.

    abstract:BACKGROUND:The treatment of deliberate self-harm (parasuicide) remains limited in efficacy. Despite a range of psychosocial, educational and pharmacological interventions only one approach, dialectical behaviour therapy, a form of cognitive-behaviour therapy (CBT), has been shown to reduce repeat episodes, but this is ...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s003329179800765x

    authors: Evans K,Tyrer P,Catalan J,Schmidt U,Davidson K,Dent J,Tata P,Thornton S,Barber J,Thompson S

    更新日期:1999-01-01 00:00:00

  • Association between organizational inequity and incidence of psychiatric disorders in female employees.

    abstract:BACKGROUND:Prior research on work-related factors in the aetiology of psychiatric disorders has been concentrated on job control, job demands and social support. To broaden the view to managerial procedures, we examined whether the extent to which employees are treated with equity in the workplace predicts their mental...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291702006591

    authors: Kivimäki M,Elovainio M,Vahtera J,Virtanen M,Stansfeld SA

    更新日期:2003-02-01 00:00:00

  • The devil is in the detail: exploring the intrinsic neural mechanisms that link attention-deficit/hyperactivity disorder symptomatology to ongoing cognition.

    abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718003598

    authors: Vatansever D,Bozhilova NS,Asherson P,Smallwood J

    更新日期:2019-05-01 00:00:00

  • Increased rates of schizophrenia among immigrants: some methodological concerns raised by Danish findings.

    abstract:BACKGROUND:Several studies during recent years have reported an increased occurrence of schizophrenia in selected immigrant groups. However, difficulties in establishing the population denominator for immigrant rates of mental disorder, selective referral for treatment, and other problems may have influenced such resul...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291797004741

    authors: Mortensen PB,Cantor-Graae E,McNeil TF

    更新日期:1997-07-01 00:00:00

  • Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis.

    abstract:BACKGROUND:Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719003568

    authors: Vieira S,Gong Q,Scarpazza C,Lui S,Huang X,Crespo-Facorro B,Tordesillas-Gutierrez D,de la Foz VO,Setien-Suero E,Scheepers F,van Haren NEM,Kahn R,Reis Marques T,Ciufolini S,Di Forti M,Murray RM,David A,Dazzan P,McGuire

    更新日期:2019-12-20 00:00:00

  • Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

    abstract:BACKGROUND:There is evidence that patients with chronic fatigue syndrome (CFS) have mild hypocortisolism. The clinical significance of this is unclear. We aimed to determine whether hypocortisolism exerted any effect on the response of CFS to cognitive behavioural therapy (CBT). METHOD:We measured 24-h urinary free co...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709990390

    authors: Roberts AD,Charler ML,Papadopoulos A,Wessely S,Chalder T,Cleare AJ

    更新日期:2010-03-01 00:00:00

  • Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.

    abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715001609

    authors: Noda Y,Silverstein WK,Barr MS,Vila-Rodriguez F,Downar J,Rajji TK,Fitzgerald PB,Mulsant BH,Vigod SN,Daskalakis ZJ,Blumberger DM

    更新日期:2015-12-01 00:00:00

  • Slow binocular rivalry in bipolar disorder.

    abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703007475

    authors: Miller SM,Gynther BD,Heslop KR,Liu GB,Mitchell PB,Ngo TT,Pettigrew JD,Geffen LB

    更新日期:2003-05-01 00:00:00

  • Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy.

    abstract:BACKGROUND:Major depressive disorder during pregnancy associates with potentially detrimental consequences for mother and child. The current study examined peripheral blood gene expression as a potential biomarker for prenatal depressive symptoms. METHOD:Maternal RNA from whole blood, plasma and the Beck Depression In...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002121

    authors: Katz ER,Stowe ZN,Newport DJ,Kelley ME,Pace TW,Cubells JF,Binder EB

    更新日期:2012-05-01 00:00:00

  • The expressed emotion of case managers of the seriously mentally ill: the influence of expressed emotion on clinical outcomes.

    abstract:BACKGROUND:Expressed emotion (EE) measured from relatives and informal carers has been consistently demonstrated to be associated with clinical outcome in schizophrenic patients. There have also been published studies that have investigated EE in professional carers that have suggested that the quality of the relations...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799001579

    authors: Tattan T,Tarrier N

    更新日期:2000-01-01 00:00:00

  • Physical activity and prevalence and incidence of mental disorders in adolescents and young adults.

    abstract:BACKGROUND:Although positive effects of physical activity on mental health indicators have been reported, the relationship between physical activity and the development of specific mental disorders is unclear. METHOD:A cross-sectional (12-month) and prospective-longitudinal epidemiological study over 4 years in a comm...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170700089X

    authors: Ströhle A,Höfler M,Pfister H,Müller AG,Hoyer J,Wittchen HU,Lieb R

    更新日期:2007-11-01 00:00:00

  • Major depression impairs incentive processing: evidence from the heart and the face.

    abstract:BACKGROUND:The present study tested the hypothesis of a differential pattern of reward and punishment responsiveness in depression measuring effort mobilization during anticipation and facial expressions during consumption. METHODS:Twenty patients with major depressive disorder (MDD) and 20 control participants worked...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001526

    authors: Franzen J,Brinkmann K,Gendolla GHE,Sentissi O

    更新日期:2019-04-01 00:00:00

  • Factors predisposing to suspected offending by adults with self-reported learning disabilities.

    abstract:BACKGROUND:This study investigated factors contributing to suspected offending behaviour by adults with a history of learning disabilities taken into custody at a city police station. METHODS:Adults charged with offences, and/or leaving custody, during a defined period, were identified as having a possible learning di...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291797004777

    authors: Winter N,Holland AJ,Collins S

    更新日期:1997-05-01 00:00:00

  • Predictors of outcome in first-episode schizophrenia over the first 4 years of illness.

    abstract:BACKGROUND:The outcome of schizophrenia appears to be more favourable than once thought. However, methodological issues, including the reliance on diagnosis at first presentation have limited the validity of outcome studies to date. METHOD:We conducted a first-episode follow-up study of 97 patients with DSM-IV schizop...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170800336X

    authors: Whitty P,Clarke M,McTigue O,Browne S,Kamali M,Kinsella A,Larkin C,O'Callaghan E

    更新日期:2008-08-01 00:00:00

  • Comparison of alternative models for personality disorders, II: 6-, 8- and 10-year follow-up.

    abstract:BACKGROUND:Several conceptual models have been considered for the assessment of personality pathology in DSM-5. This study sought to extend our previous findings to compare the long-term predictive validity of three such models: the five-factor model (FFM), the schedule for nonadaptive and adaptive personality (SNAP), ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002601

    authors: Morey LC,Hopwood CJ,Markowitz JC,Gunderson JG,Grilo CM,McGlashan TH,Shea MT,Yen S,Sanislow CA,Ansell EB,Skodol AE

    更新日期:2012-08-01 00:00:00

  • Developmental influences on symptom expression in antipsychotic-naïve first-episode psychosis.

    abstract:BACKGROUND:The neurodevelopmental model of psychosis was established over 30 years ago; however, the developmental influence on psychotic symptom expression - how age affects clinical presentation in first-episode psychosis - has not been thoroughly investigated. METHODS:Using generalized additive modeling, which allo...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720003463

    authors: Bridgwater M,Bachman P,Tervo-Clemmens B,Haas G,Hayes R,Luna B,Salisbury DF,Jalbrzikowski M

    更新日期:2020-10-06 00:00:00

  • Endocrine changes and clinical profiles in depression: I. The dexamethasone suppression test.

    abstract::Hypothalamic-pituitary-adrenal axis function was investigated in 72 patients with primary depression. Forty-four per cent of the patients demonstrated abnormal suppression of their cortisol levels after a 1 mg overnight dexamethasone suppression test. Patients with abnormal suppression ('non-suppressors') were not cle...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700019711

    authors: Calloway SP,Dolan RJ,Fonagy P,De Souza VF,Wakeling A

    更新日期:1984-11-01 00:00:00

  • Risk factors for major depression during midlife among a community sample of women with and without prior major depression: are they the same or different?

    abstract:BACKGROUND:Women's vulnerability for a first lifetime-onset of major depressive disorder (MDD) during midlife is substantial. It is unclear whether risk factors differ for first lifetime-onset and recurrent MDD. Identifying these risk factors can provide more focused depression screening and earlier intervention. This ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/S0033291714002773

    authors: Bromberger JT,Schott L,Kravitz HM,Joffe H

    更新日期:2015-06-01 00:00:00