Neuropsychological deficits and CT scan changes in elderly depressives.

Abstract:

:A number of computerized tests were used to study visual attention, memory and learning in elderly depressed patients. Impairment was found in approximately 70% of depressed patients and was seen particularly in memory and in measures of latency. Depressed patients showed equivalent impairment in short-term memory but less impairment in conditional associative learning compared to a group of patients with early dementia of the Alzheimer-type (DAT), matched for age and pre-morbid IQ. With respect to qualitative differences between depression and DAT, depressed patients showed a different pattern of errors and a consistently prolonged latency of response which was independent of delay in a delayed matching-to-sample test. On recovery from depression, although improvement was seen in most test scores, performance in measures of latency and in a number of tests of memory and learning failed to reach the level seen in a group of matched control subjects and approximately 35% of patients continued to show impairment. For the depressed patients, ventricular brain ratio (VBR) correlated with measures of slowing. In addition, in the 'recovered-depressives', VBR correlated with poor performance at high levels of task difficulty. These findings are discussed with respect to previous literature on the pattern of cognitive impairment and CT scan findings in depression.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Abas MA,Sahakian BJ,Levy R

doi

10.1017/s0033291700017025

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

507-20

issue

3

eissn

0033-2917

issn

1469-8978

journal_volume

20

pub_type

杂志文章
  • The temporal dynamics of sleep disturbance and psychopathology in psychosis: a digital sampling study.

    abstract:BACKGROUND:Sleep disruption is a common precursor to deterioration and relapse in people living with psychotic disorders. Understanding the temporal relationship between sleep and psychopathology is important for identifying and developing interventions which target key variables that contribute to relapse. METHODS:We...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004857

    authors: Meyer N,Joyce DW,Karr C,de Vos M,Dijk DJ,Jacobson NC,MacCabe JH

    更新日期:2021-01-12 00:00:00

  • Effects of childhood trauma on left inferior frontal gyrus function during response inhibition across psychotic disorders.

    abstract:BACKGROUND:Childhood trauma is a risk factor for psychosis. Deficits in response inhibition are common to psychosis and trauma-exposed populations, and associated brain functions may be affected by trauma exposure in psychotic disorders. We aimed to identify the influence of trauma-exposure on brain activation and func...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717002884

    authors: Quidé Y,O'Reilly N,Watkeys OJ,Carr VJ,Green MJ

    更新日期:2018-07-01 00:00:00

  • Psychiatric disorder in a rural and an urban population: 2. Sensitivity to loss.

    abstract::In an earlier paper we found that a model of depression developed on a sample of women in a London population was confirmed in a female population in the Outer Hebrides. Differences in the rates of onset and chronic cases between the two populations, however, suggested that the Scottish women might be more likely to b...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700052892

    authors: Prudo R,Brown GW,Harris T,Dowland J

    更新日期:1981-08-01 00:00:00

  • Should euthanasia and assisted suicide for psychiatric disorders be permitted? A systematic review of reasons.

    abstract:BACKGROUND:Euthanasia and assisted suicide (EAS) based on a psychiatric disorder (psychiatric EAS) continue to pose ethical and policy challenges, even in countries where the practice has been allowed for years. We conducted a systematic review of reasons, a specific type of review for bioethical questions designed to ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720001543

    authors: Nicolini ME,Kim SYH,Churchill ME,Gastmans C

    更新日期:2020-06-01 00:00:00

  • Effects of psychoeducation on helpful support for complicated grief: a preliminary randomized controlled single-blind study.

    abstract:BACKGROUND:Complicated grief is a distinct psychological response of individuals facing the loss of a loved one and can lead to many types of adverse health outcomes. Although social support may be beneficial, few studies have examined the beneficial effects of helpful support on complicated grief following bereavement...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291715001658

    authors: Nam IS

    更新日期:2016-01-01 00:00:00

  • Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.

    abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715001609

    authors: Noda Y,Silverstein WK,Barr MS,Vila-Rodriguez F,Downar J,Rajji TK,Fitzgerald PB,Mulsant BH,Vigod SN,Daskalakis ZJ,Blumberger DM

    更新日期:2015-12-01 00:00:00

  • Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

    abstract::The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720002172

    authors: Sideli L,Murray RM,Schimmenti A,Corso M,La Barbera D,Trotta A,Fisher HL

    更新日期:2020-08-01 00:00:00

  • Elasticity and confabulation in schizophrenic delusions.

    abstract:BACKGROUND:This experiment examines two aspects of delusional cognition that have been reported clinically but not investigated empirically. These are the incorporation of potentially conflicting information into the recall of delusion-related scripts and the type and amount of material produced additional to that pres...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170200538x

    authors: Simpson J,Done DJ

    更新日期:2002-04-01 00:00:00

  • Insight correlates in child- and adolescent-onset first episodes of psychosis: results from the CAFEPS study.

    abstract:BACKGROUND:The correlates of insight in early-onset psychosis have received little previous attention. METHOD:We studied clinical correlates of insight in a sample of 110 adolescent recent-onset psychosis patients (mean age 15.53 years; psychotic symptoms present for <6 months). Insight was measured with the Scale to ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708004868

    authors: Parellada M,Fraguas D,Bombín I,Otero S,Castro-Fornieles J,Baeza I,Gonzalez-Pinto A,Graell M,Soutullo C,Paya B,Arango C

    更新日期:2009-09-01 00:00:00

  • The duration and timing of maternal depression as a moderator of the relationship between dependent interpersonal stress, contextual risk and early child dysregulation.

    abstract:BACKGROUND:Risk factors that are associated with depression in the mother also negatively affect the child. This research sought to extend current knowledge by examining the duration and timing of maternal depression as a moderator of: (1) the impact of dependent interpersonal stress (DIS), such as partner conflict or ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291712002450

    authors: Barker ED

    更新日期:2013-08-01 00:00:00

  • Slow binocular rivalry in bipolar disorder.

    abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703007475

    authors: Miller SM,Gynther BD,Heslop KR,Liu GB,Mitchell PB,Ngo TT,Pettigrew JD,Geffen LB

    更新日期:2003-05-01 00:00:00

  • An attention and interpretation bias for illness-specific information in chronic fatigue syndrome.

    abstract:BACKGROUND:Studies have shown that specific cognitions and behaviours play a role in maintaining chronic fatigue syndrome (CFS). However, little research has investigated illness-specific cognitive processing in CFS. This study investigated whether CFS participants had an attentional bias for CFS-related stimuli and a ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716002890

    authors: Hughes AM,Chalder T,Hirsch CR,Moss-Morris R

    更新日期:2017-04-01 00:00:00

  • Development of a new self-report questionnaire to measure self esteem.

    abstract::In constructing a new self-report questionnaire for measuring self esteem, the aim has been to satisfy psychometric requirements without sacrificing the intuitive meaning of the concept. Self esteem is seen as a composite, and examination of its components may have more analytic or predictive value than 'global' score...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001254x

    authors: Robson P

    更新日期:1989-05-01 00:00:00

  • Pathways to psychiatric care in Ethiopia.

    abstract:BACKGROUND:Understanding the pathways to psychiatric care and recognition of delay points are crucial for the development of interventions that aim to improve access to mental health-care services. METHOD:Over a 2-month period in 2003, a total of 1044 patients at the commencement of new episodes of care at Amanuel Spe...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708003929

    authors: Bekele YY,Flisher AJ,Alem A,Baheretebeb Y

    更新日期:2009-03-01 00:00:00

  • Cognitive function in unaffected twins discordant for affective disorder.

    abstract:BACKGROUND:Patients may present with cognitive impairment in the euthymic phase of affective disorder, but it is unclear whether the impairment is prevalent before onset of the illness. The aim of the present study was to examine the hypothesis that genetic liability to affective disorder is associated with cognitive i...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706007896

    authors: Christensen MV,Kyvik KO,Kessing LV

    更新日期:2006-08-01 00:00:00

  • Pathways from assaultive violence to post-traumatic stress, depression, and generalized anxiety symptoms through stressful life events: longitudinal mediation models.

    abstract:BACKGROUND:Assaultive violence events are associated with increased risk for adverse psychiatric outcomes, including post-traumatic stress (PTS), depression, and generalized anxiety. Prior research has indicated that economic, legal, and social stressors that could follow assaultive events may explain the increased ris...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717001143

    authors: Lowe SR,Joshi S,Galea S,Aiello AE,Uddin M,Koenen KC,Cerdá M

    更新日期:2017-10-01 00:00:00

  • Abnormal diurnal weight gain among chronically psychotic patients contrasted with acutely psychotic patients and normals.

    abstract::We found diurnal weight gain to be abnormal among 28 institutionalized chronically psychotic patients. They were weighed daily for 15 days at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and th...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700011065

    authors: Vieweg WV,Godleski LS,Mitchell M,Hundley PL,Yank GR

    更新日期:1989-02-01 00:00:00

  • Posttraumatic stress disorder symptom trajectories within the first year following emergency department admissions: pooled results from the International Consortium to predict PTSD.

    abstract:BACKGROUND:Research exploring the longitudinal course of posttraumatic stress disorder (PTSD) symptoms has documented four modal trajectories (low, remitting, high, and delayed), with proportions varying across studies. Heterogeneity could be due to differences in trauma types and patient demographic characteristics. ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719004008

    authors: Lowe SR,Ratanatharathorn A,Lai BS,van der Mei W,Barbano AC,Bryant RA,Delahanty DL,Matsuoka YJ,Olff M,Schnyder U,Laska E,Koenen KC,Shalev AY,Kessler RC

    更新日期:2020-02-03 00:00:00

  • Allusive thinking, the Word Halo and verbosity.

    abstract::The concept of allusive thinking is briefly reviewed and a Pavlovian model of thinking advanced. It is hypothesized that allusive, as compared with non-allusive thinkers, have a broader but less intense attention process associated with weaker inhibition. From this model it was predicted that on word tests which requi...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700004414

    authors: Armstrong MS,McConaghy N

    更新日期:1977-08-01 00:00:00

  • Exclusion criteria in the diagnostic classifications of DSM-IV and ICD-10: revisiting the co-occurrence of psychiatric syndromes.

    abstract:BACKGROUND:Exclusion criteria are present in almost all diagnostic categories in both DSM-IV and ICD-10. These exclusion criteria state that one diagnosis is not made if it is 'due to' another disorder. However, there is little empirical evidence demonstrating that the hierarchy imposed by the exclusion criteria is mea...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291702006189

    authors: Slade T,Andrews G

    更新日期:2002-10-01 00:00:00

  • Complex trauma of war captivity: a prospective study of attachment and post-traumatic stress disorder.

    abstract:BACKGROUND:Victims of war captivity sometimes suffer from complex post-traumatic stress disorder (PTSD), a unique form of PTSD that entails various alterations in personality. These alterations may involve changes in attachment orientation. METHOD:The sample comprised two groups of veterans from the 1973 Yom Kippur Wa...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708002808

    authors: Solomon Z,Dekel R,Mikulincer M

    更新日期:2008-10-01 00:00:00

  • Classification of severe school attendance problems.

    abstract::Sixty-four children taken to court for failure to attend school were reliably classified into 4 groups, according to whether they exhibited the features of 'school refusal' and/or 'truancy'. About a fifth of them were found to exhibit 'school refusal'; a third showed 'truancy'; less than a sixth exhibited both 'school...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700021024

    authors: Berg I,Casswell G,Goodwin A,Hullin R,McGuire R,Tagg G

    更新日期:1985-02-01 00:00:00

  • Base-rates, cut-points and interaction effects: the problem with dichotomized continuous variables.

    abstract::On the background of the recent discussion about the appropriateness of linear difference and ratio models for testing interaction effects of social support and stress, it is argued that interaction effects are basically unstable when dichotomized continuous variables are analysed. A data set with known interrelations...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700008394

    authors: Veiel HO

    更新日期:1988-08-01 00:00:00

  • Do cannabis and urbanicity co-participate in causing psychosis? Evidence from a 10-year follow-up cohort study.

    abstract:BACKGROUND:Cannabis use is considered a component cause of psychotic illness, interacting with genetic and other environmental risk factors. Little is known, however, about these putative interactions. The present study investigated whether an urban environment plays a role in moderating the effects of adolescent canna...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711000511

    authors: Kuepper R,van Os J,Lieb R,Wittchen HU,Henquet C

    更新日期:2011-10-01 00:00:00

  • Parental death in childhood and risk of adult depressive disorders: a review.

    abstract::The authors review the evidence that parental death in childhood predisposes to depressive disorders in later life. The findings in general are quite inconsistent; this is due in part to the methodological limitations of most studies, principally that of inadequate control of potentially confounding variables. Where e...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700044044

    authors: Tennant C,Bebbington P,Hurry J

    更新日期:1980-05-01 00:00:00

  • Relationships between cardiovascular and immunological changes in an experimental stress model.

    abstract::To investigate the relationships between cardiovascular variables (SBP, DBP, and HR) and circulating natural killer (NK) cell numbers, 70 male volunteers were subjected to a rest condition (N = 30) or a stressful laboratory task (N = 40). At baseline, no significant relationships could be demonstrated between the numb...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291700036229

    authors: Benschop RJ,Godaert GL,Geenen R,Brosschot JF,De Smet MB,Olff M,Heijnen CJ,Ballieux RE

    更新日期:1995-03-01 00:00:00

  • Characterizing the effects of sertraline in post-traumatic stress disorder.

    abstract:BACKGROUND:Sertraline has a proved efficacy in post-traumatic stress disorder (PTSD), but it is unknown which symptoms respond or in what sequence this occurs. Such information might be useful clinically and heuristically. METHOD:The study examined the effects of sertraline on the individual symptoms of PTSD. It also ...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291702005469

    authors: Davidson JR,Landerman LR,Farfel GM,Clary CM

    更新日期:2002-05-01 00:00:00

  • Suicidal behaviour: an epidemiological and genetic study.

    abstract:BACKGROUND:Psychiatric history, familial history of suicide attempts, and certain traumatic life events are important predictors of suicidal thoughts and behaviour. We examined the epidemiology and genetics of suicidality (i.e. reporting persistent suicidal thoughts or a plan or suicide attempt) in a large community-ba...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291798006916

    authors: Statham DJ,Heath AC,Madden PA,Bucholz KK,Bierut L,Dinwiddie SH,Slutske WS,Dunne MP,Martin NG

    更新日期:1998-07-01 00:00:00

  • Variations in referral pattern to the psychiatric services by general practitioners.

    abstract::Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700030865

    authors: Robertson NC

    更新日期:1979-05-01 00:00:00

  • Serum creatine phosphokinase levels and assaultive behaviour of psychotic patients.

    abstract::Serum creatine phosphokinase (CPK) levels were compared with assaultive behaviour by 46 psychiatric patients. Significant relationships were found between CPK level and violent behaviour prior to admission and CPK level and seclusion as a danger to others while in hospital. No relationship was found between CPK level ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700003275

    authors: Isaacs JS,Yesavage JA

    更新日期:1984-02-01 00:00:00