Abstract:
BACKGROUND:Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD:We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. RESULTS:We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. CONCLUSIONS:Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Sanders AR,Martin ER,Beecham GW,Guo S,Dawood K,Rieger G,Badner JA,Gershon ES,Krishnappa RS,Kolundzija AB,Duan J,Gejman PV,Bailey JMdoi
10.1017/S0033291714002451subject
Has Abstractpub_date
2015-05-01 00:00:00pages
1379-88issue
7eissn
0033-2917issn
1469-8978pii
S0033291714002451journal_volume
45pub_type
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