Genome-wide scan demonstrates significant linkage for male sexual orientation.

Abstract:

BACKGROUND:Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD:We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (908 analyzed individuals in 384 families), by far the largest study of its kind to date. RESULTS:We identified two regions of linkage: the pericentromeric region on chromosome 8 (maximum two-point LOD = 4.08, maximum multipoint LOD = 2.59), which overlaps with the second strongest region from a previous separate linkage scan of 155 brother pairs; and Xq28 (maximum two-point LOD = 2.99, maximum multipoint LOD = 2.76), which was also implicated in prior research. CONCLUSIONS:Results, especially in the context of past studies, support the existence of genes on pericentromeric chromosome 8 and chromosome Xq28 influencing development of male sexual orientation.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Sanders AR,Martin ER,Beecham GW,Guo S,Dawood K,Rieger G,Badner JA,Gershon ES,Krishnappa RS,Kolundzija AB,Duan J,Gejman PV,Bailey JM

doi

10.1017/S0033291714002451

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

1379-88

issue

7

eissn

0033-2917

issn

1469-8978

pii

S0033291714002451

journal_volume

45

pub_type

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