Abstract:
BACKGROUND:Alterations in self-monitoring have been reported in patients with psychotic disorders, but it remains unclear to what degree they represent true indicators of familial vulnerability for psychosis. METHOD:An error-correction action-monitoring task was used to examine self-monitoring in 42 patients with schizophrenia, 32 of their unaffected siblings and 41 healthy controls. RESULTS:Significant between-group differences in self-monitoring accuracy were found (χ2=29.3, p<0.0001), patients performing worst and unaffected siblings performing at an intermediate level compared to controls (all between-group differences p<0.05). In the combined group of healthy controls and unaffected siblings, detection accuracy was associated with positive schizotypy as measured by the Structured Interview for Schizotypy - Revised (SIS-R) (β=-0.16, s.e.=0.07, p=0.026), but not with negative schizotypy (β=-0.05, s.e.=0.12, p=0.694). In patients, psychotic symptoms were not robustly associated with detection accuracy (β=-0.01, s.e.=0.01, p=0.094), although stratified analysis revealed suggestive evidence for association in patients not currently using antipsychotic medication (β=-0.03, s.e.=0.01, p=0.052), whereas no association was found in patients on antipsychotic medication (β=-0.01, s.e.=0.01, p=0.426). A similar pattern of associations was found for negative symptoms. CONCLUSIONS:Alterations in self-monitoring may be associated with familial risk and expression of psychosis. The association between psychotic symptoms and self-monitoring in patients may be affected by antipsychotic medication, which may explain previous inconsistencies in the literature.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Hommes J,Krabbendam L,Versmissen D,Kircher T,van Os J,van Winkel Rdoi
10.1017/S0033291711001152subject
Has Abstractpub_date
2012-02-01 00:00:00pages
235-45issue
2eissn
0033-2917issn
1469-8978pii
S0033291711001152journal_volume
42pub_type
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