Self-monitoring as a familial vulnerability marker for psychosis: an analysis of patients, unaffected siblings and healthy controls.

Abstract:

BACKGROUND:Alterations in self-monitoring have been reported in patients with psychotic disorders, but it remains unclear to what degree they represent true indicators of familial vulnerability for psychosis. METHOD:An error-correction action-monitoring task was used to examine self-monitoring in 42 patients with schizophrenia, 32 of their unaffected siblings and 41 healthy controls. RESULTS:Significant between-group differences in self-monitoring accuracy were found (χ2=29.3, p<0.0001), patients performing worst and unaffected siblings performing at an intermediate level compared to controls (all between-group differences p<0.05). In the combined group of healthy controls and unaffected siblings, detection accuracy was associated with positive schizotypy as measured by the Structured Interview for Schizotypy - Revised (SIS-R) (β=-0.16, s.e.=0.07, p=0.026), but not with negative schizotypy (β=-0.05, s.e.=0.12, p=0.694). In patients, psychotic symptoms were not robustly associated with detection accuracy (β=-0.01, s.e.=0.01, p=0.094), although stratified analysis revealed suggestive evidence for association in patients not currently using antipsychotic medication (β=-0.03, s.e.=0.01, p=0.052), whereas no association was found in patients on antipsychotic medication (β=-0.01, s.e.=0.01, p=0.426). A similar pattern of associations was found for negative symptoms. CONCLUSIONS:Alterations in self-monitoring may be associated with familial risk and expression of psychosis. The association between psychotic symptoms and self-monitoring in patients may be affected by antipsychotic medication, which may explain previous inconsistencies in the literature.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Hommes J,Krabbendam L,Versmissen D,Kircher T,van Os J,van Winkel R

doi

10.1017/S0033291711001152

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

235-45

issue

2

eissn

0033-2917

issn

1469-8978

pii

S0033291711001152

journal_volume

42

pub_type

杂志文章
  • The prognostic significance of psychological factors in the management of chronic bronchitis.

    abstract::Eighty-three chronic obstructive bronchitic patients were psychologically assessed before being randomly allocated to 1 of 3 management regimes. The following measures were taken: psychiatric disturbance, personality, social-desirability response set, vocabulary, expectations about treatment, attitudes and beliefs abo...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1017/s0033291700021565

    authors: Rutter BM

    更新日期:1979-02-01 00:00:00

  • Auditory signal detectability and facilitation of simple reaction time in psychiatric patients and non-patients.

    abstract::Patients diagnosed on the basis of structured interviews as having affective psychoses were less sensitive in detecting the presence of a transient auditory signal than were schizophrenic patients or non-patients. Patients with affective psychoses also benefited more (their reaction time was more reduced) than the oth...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700056622

    authors: Bruder GE,Sutton S,Babkoff H,Gurland BJ,Yozawitz A,Fleiss JL

    更新日期:1975-08-01 00:00:00

  • Childhood adversities and risk for suicidal ideation and attempts: a longitudinal population-based study.

    abstract:BACKGROUND:Developmental adversities may be risk factors for adult suicidal behavior, but this relationship has rarely been studied prospectively. The present study examined the association between childhood adversities and new onset suicidal ideation and attempts in an adult population-based sample. METHOD:The study ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706008646

    authors: Enns MW,Cox BJ,Afifi TO,De Graaf R,Ten Have M,Sareen J

    更新日期:2006-12-01 00:00:00

  • A comparative psychiatric assessment of patients with chronic fatigue syndrome and muscle disease.

    abstract::The psychiatric status of patients with chronic fatigue syndrome (N = 34) and muscle disease (N = 24) attending a general medical clinic was studied. Among fatigue patients 14 (41.2%) were cases and a further 9 (26.5%) were subcases of psychiatric disorder as defined by CATEGO. A variety of diagnoses was found. Signif...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170002225x

    authors: Wood GC,Bentall RP,Göpfert M,Edwards RH

    更新日期:1991-08-01 00:00:00

  • The validity and reliability of the fatigue syndrome that follows glandular fever.

    abstract::The validity and reliability of an empirically defined fatigue syndrome were tested in a prospective cohort study of 245 primary care patients, with glandular fever or an upper respiratory tract infection. Subjects were interviewed three times in the 6 months after onset. Subjects with the empirically defined fatigue ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700037405

    authors: White PD,Grover SA,Kangro HO,Thomas JM,Amess J,Clare AW

    更新日期:1995-09-01 00:00:00

  • Genome-wide scan demonstrates significant linkage for male sexual orientation.

    abstract:BACKGROUND:Findings from family and twin studies support a genetic contribution to the development of sexual orientation in men. However, previous studies have yielded conflicting evidence for linkage to chromosome Xq28. METHOD:We conducted a genome-wide linkage scan on 409 independent pairs of homosexual brothers (90...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291714002451

    authors: Sanders AR,Martin ER,Beecham GW,Guo S,Dawood K,Rieger G,Badner JA,Gershon ES,Krishnappa RS,Kolundzija AB,Duan J,Gejman PV,Bailey JM

    更新日期:2015-05-01 00:00:00

  • Cognition as a treatment target in depression.

    abstract::Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...

    journal_title:Psychological medicine

    pub_type: 社论

    doi:10.1017/S0033291716003123

    authors: Kaser M,Zaman R,Sahakian BJ

    更新日期:2017-04-01 00:00:00

  • Fronto-thalamic structural and effective connectivity and delusions in schizophrenia: a combined DTI/DCM study.

    abstract:BACKGROUND:Schizophrenia (SZ) is a complex disorder characterized by a range of behavioral and cognitive symptoms as well as structural and functional alterations in multiple cortical and subcortical structures. SZ is associated with reduced functional network connectivity involving core regions such as the anterior ci...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000859

    authors: Csukly G,Szabó Á,Polgár P,Farkas K,Gyebnár G,Kozák LR,Stefanics G

    更新日期:2020-04-24 00:00:00

  • Cognitive impairment in the euthymic phase of affective disorder.

    abstract:BACKGROUND:A review of studies of cognition in the euthymic phase of unipolar and bipolar affective disorder reveals diverging results. METHODS:The study was designed as a controlled cohort study, with the Danish psychiatric case register of admissions used to identify patients and the Danish civil register to identif...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291798006862

    authors: Kessing LV

    更新日期:1998-09-01 00:00:00

  • The association of parental fatal and non-fatal suicidal behaviour with offspring suicidal behaviour and depression: a systematic review and meta-analysis.

    abstract:BACKGROUND:Children whose parents die by, or attempt, suicide are believed to be at greater risk of suicidal behaviours and affective disorders. We systematically reviewed the literature on these associations and, using meta-analysis, estimated the strength of associations as well as investigated potential effect modif...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291711002753

    authors: Geulayov G,Gunnell D,Holmen TL,Metcalfe C

    更新日期:2012-08-01 00:00:00

  • Erythrocyte membrane cation carrier, relapse rate of manic-depressive illness and response to lithium.

    abstract::Biochemical studies of manic-depressive psychosis usually correlates biochemical findings with current affective state and hence any significant findings could be secondary to mood change. The present study attempts to correlate measures of the erythrocyte membrane cation carrier with clinical events, remote in time f...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291700013805

    authors: Naylor GJ,Dick DA,Dick EG

    更新日期:1976-05-01 00:00:00

  • Two-year follow-up of the patients included in the WHO International Pilot Study of Schizophrenia.

    abstract::Over 90% of the 1202 patients investigated in the 9 centres collaborating in the International Pilot Study of Schizophrenia were traced 2 years after the initial examination and on the average over 75% of them were re-examined, using standardized instruments and methods. Results indicate that patients diagnosed as sch...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700004517

    authors: Sartorius N,Jablensky A,Shapiro R

    更新日期:1977-08-01 00:00:00

  • Life events and escape in conversion disorder.

    abstract:BACKGROUND:Psychological models of conversion disorder (CD) traditionally assume that psychosocial stressors are identifiable around symptom onset. In the face of limited supportive evidence such models are being challenged. METHOD:Forty-three motor CD patients, 28 depression patients and 28 healthy controls were asse...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716000714

    authors: Nicholson TR,Aybek S,Craig T,Harris T,Wojcik W,David AS,Kanaan RA

    更新日期:2016-09-01 00:00:00

  • Risk factors for physical symptoms after a disaster: a longitudinal study.

    abstract:BACKGROUND:Although symptoms such as fatigue, headache and pain in bones and muscles are common after disasters, risk factors for these symptoms among disaster survivors have rarely been studied. We examined predisposing, precipitating and perpetuating factors for these physical symptoms among survivors of a man-made d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170700133X

    authors: van den Berg B,Grievink L,van der Velden PG,Yzermans CJ,Stellato RK,Lebret E,Brunekreef B

    更新日期:2008-04-01 00:00:00

  • Does staff-patient agreement on needs for care predict a better mental health outcome? A 4-year follow-up in a community service.

    abstract:BACKGROUND:Patients treated in primary care settings report better mental outcomes when they agree with practitioners about the nature of their core presenting problems. However, no study has examined the impact of staff-patient agreement on treatment outcomes in specialist mental health services. We investigated wheth...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707000785

    authors: Lasalvia A,Bonetto C,Tansella M,Stefani B,Ruggeri M

    更新日期:2008-01-01 00:00:00

  • Prevalence of psychotic symptoms in childhood and adolescence: a systematic review and meta-analysis of population-based studies.

    abstract:BACKGROUND:Psychotic symptoms occur more frequently in the general population than psychotic disorder and index risk for psychopathology. Multiple studies have reported on the prevalence of these symptoms using self-report questionnaires or clinical interviews but there is a lack of consensus about the prevalence of ps...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291711002960

    authors: Kelleher I,Connor D,Clarke MC,Devlin N,Harley M,Cannon M

    更新日期:2012-09-01 00:00:00

  • Distribution of health anxiety in a general adult population and associations with demographic and social network characteristics.

    abstract:BACKGROUND:Health anxiety (HA) is associated with increased risk of disability, increased health care utilization and reduced quality of life. However, there is no consensus on which factors are important for the level of HA. The aim of this study was to explore the distribution of HA in a general adult population and ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004122

    authors: Norbye AD,Abelsen B,Førde OH,Ringberg U

    更新日期:2020-11-13 00:00:00

  • Chronotherapeutics (light and wake therapy) in affective disorders.

    abstract::The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic s...

    journal_title:Psychological medicine

    pub_type: 社论

    doi:10.1017/s003329170500437x

    authors: Wirz-Justice A,Benedetti F,Berger M,Lam RW,Martiny K,Terman M,Wu JC

    更新日期:2005-07-01 00:00:00

  • Accuracy of diagnostic classification algorithms using cognitive-, electrophysiological-, and neuroanatomical data in antipsychotic-naïve schizophrenia patients.

    abstract:BACKGROUND:A wealth of clinical studies have identified objective biomarkers, which separate schizophrenia patients from healthy controls on a group level, but current diagnostic systems solely include clinical symptoms. In this study, we investigate if machine learning algorithms on multimodal data can serve as a fram...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718003781

    authors: Ebdrup BH,Axelsen MC,Bak N,Fagerlund B,Oranje B,Raghava JM,Nielsen MØ,Rostrup E,Hansen LK,Glenthøj BY

    更新日期:2019-12-01 00:00:00

  • Lymphocyte numbers in endogenous depression.

    abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700024934

    authors: Murphy D,Gardner R,Greden JF,Carroll BJ

    更新日期:1987-05-01 00:00:00

  • The premenstrual syndrome--a reappraisal of the concept and the evidence.

    abstract::The Premenstrual Syndrome (PMS) remains a controversial issue. As a clinical concept it is surrounded by confusion. Attempts to establish a consensus definition have resulted in the majority of women seeking help for such problems excluded from the diagnosis. Furthermore, there is no consensus about how such problems ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0264180100001272

    authors: Bancroft J

    更新日期:1993-01-01 00:00:00

  • Alexithymia and frontal-amygdala functional connectivity in North Korean refugees.

    abstract:BACKGROUND:Refugees commonly experience difficulties with emotional processing, such as alexithymia, due to stressful or traumatic experiences. However, the functional connectivity of the amygdala, which is central to emotional processing, has yet to be assessed in refugees. Thus, the present study investigated the res...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719000175

    authors: Kim N,Park I,Lee YJ,Jeon S,Kim S,Lee KH,Park J,Kim HK,Gwaq AR,Jun JY,Yoo SY,Lee SH,Kim SJ

    更新日期:2020-01-01 00:00:00

  • Precursors and metabolites of 5-hydroxytryptamine and dopamine in the ventricular cerebrospinal fluid of psychiatric patients.

    abstract::Tryptophan and 5-hydroxyindoleacetic acid (precursor and metabolite respectively of 5-hydroxytryptamine) were determined in ventricular CSF of psychiatric patients undergoing stereotactic subcaudate tractotomy. Tyrosine and homovanillic acid (precursor and metabolite respectively of dopamine) were also determined. Res...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001583x

    authors: Bridges PK,Bartlett JR,Sepping P,Kantamaneni BD,Curzon G

    更新日期:1976-08-01 00:00:00

  • Case definition and case identification in psychiatric epidemiology: review and assessment.

    abstract::Psychiatric epidemiology has advanced considerably since early studies of hospital populations. The direction of this advance has been away from the study of populations of hospital psychiatric patients towards the study of psychiatric disorder in general practice and the community as a whole. Just as the populations ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700039635

    authors: Williams P,Tarnopolsky A,Hand D

    更新日期:1980-02-01 00:00:00

  • Systematic review of multi-symptom conditions in Gulf War veterans.

    abstract:BACKGROUND:Gulf War veterans have a number of health complaints. We therefore decided to carry out a systematic review to identify and summarize the findings from studies that have assessed multi-symptom conditions in Gulf War veterans and in an unexposed comparison group. METHOD:Studies published between January 1990...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291705006975

    authors: Thomas HV,Stimpson NJ,Weightman AL,Dunstan F,Lewis G

    更新日期:2006-06-01 00:00:00

  • The complex relationship between depressive symptoms and functional limitations in community-dwelling older adults: the impact of subthreshold depression.

    abstract:BACKGROUND:Depressive symptoms above screening thresholds have been shown to predict functional decline in older adults. Less is known about the impact of subthreshold depression, and whether more symptoms confer significantly greater risk compared to fewer symptoms. METHOD:Using data from the Duke Established Populat...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709005650

    authors: Hybels CF,Pieper CF,Blazer DG

    更新日期:2009-10-01 00:00:00

  • Language and dementia: a review.

    abstract::In the literature on dementia the presence or absence of language deficits has come to occupy a pivotal position with respect to certain nosological and nosographical issues. These are reviewed critically, together with the results of experimental investigations which have sought to elucidate the nature of the languag...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700001938

    authors: Hart S

    更新日期:1988-02-01 00:00:00

  • Use of a sequencing task designed to stress the supervisory system in schizophrenic subjects.

    abstract:BACKGROUND:We investigated whether schizophrenic subjects are impaired in non-routine behaviour because of the dysfunction of a general executive component labelled, in neuropsychological terms, the supervisory system. METHODS:A specific verbal sequencing test was designed for this purpose. Subjects had to perform seq...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291797005515

    authors: Robert PH,Migneco V,Chaix I,Berthet L,Kazes M,Danion JM,Baudu C,Darcourt G

    更新日期:1997-11-01 00:00:00

  • How abnormal is the desire for slimness? A survey of eating attitudes and behaviour among Chinese undergraduates in Hong Kong.

    abstract::Using the 40-item Eating Attitudes Test and other self-report questions, a two-stage screening survey of 1020 (F 646, M 374) Chinese bilingual university students in Hong Kong showed that although female students were 'underweight' by Western standard, the majority of them and nearly all female students above a body m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700028531

    authors: Lee S

    更新日期:1993-05-01 00:00:00

  • Life events, social support and depression in childbirth: perspectives from a rural community in the developing world.

    abstract:BACKGROUND:High rates of depression associated with childbirth have been reported in many parts of the developing world. However, the prevalence and associations of antenatal and post-natal depression in the rural population remain unknown. Disability associated with depression and its impact on infant health and devel...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703008286

    authors: Rahman A,Iqbal Z,Harrington R

    更新日期:2003-10-01 00:00:00