Bereavement, multimorbidity and mortality: a population-based study using bereavement as an indicator of mental stress.

Abstract:

BACKGROUND:Mental stress is associated with higher mortality, but it remains controversial whether the association is causal or a consequence of a higher physical disease burden in those with a high mental stress load. Understanding causality is important when developing targeted interventions. We aimed to estimate the effect of mental stress on mortality by performing a 'natural' experiment using spousal bereavement as a disease-independent mental stressor. METHODS:We followed a population-based matched cohort, including all individuals in Denmark bereaved in 1997-2014, for 17 years. Prospectively recorded register data were obtained for civil and vital status, 39 mental and physical diagnoses, and socioeconomic factors. RESULTS:In total, 389 316 bereaved individuals were identified and 137 247 died during follow-up. Bereaved individuals had higher all-cause mortality than non-bereaved references in the entire study period. The relative mortality in the bereaved individuals was highest shortly after the loss (adjusted hazard ratio (aHR), first month: 2.50, 95% confidence interval (CI) 2.37-2.63; aHR, 6-12 months: 1.38, 95% CI 1.34-1.42). The excess mortality rate associated with bereavement rose with increasing number of physical diseases (1.33 v. 7.00 excess death per 1000 person-months for individuals with 0 v. ⩾3 physical conditions during the first month) and was exacerbated by the presence of mental illness. The excess mortality among bereaved individuals was primarily due to death from natural causes. CONCLUSIONS:Bereavement was associated with increased short-term and long-term mortality, even after adjustment for morbidities, which suggests that mental stress may play a causal role in excess mortality.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Prior A,Fenger-Grøn M,Davydow DS,Olsen J,Li J,Guldin MB,Vestergaard M

doi

10.1017/S0033291717002380

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

1437-1443

issue

9

eissn

0033-2917

issn

1469-8978

pii

S0033291717002380

journal_volume

48

pub_type

杂志文章
  • Cognitive ability as a moderator of the association between social disadvantage and psychological distress: evidence from a population-based sample.

    abstract:BACKGROUND:Social disadvantage consistently predicts both self-reported distress and clinically diagnosed disorders such as depression. Yet, many individuals who are exposed to disadvantage do not report high levels of distress. This study extends our recent work showing that high cognitive ability may protect against ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718002118

    authors: Bridger E,Daly M

    更新日期:2019-07-01 00:00:00

  • Occupational differences in US Army suicide rates.

    abstract:BACKGROUND:Civilian suicide rates vary by occupation in ways related to occupational stress exposure. Comparable military research finds suicide rates elevated in combat arms occupations. However, no research has evaluated variation in this pattern by deployment history, the indicator of occupation stress widely consid...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715001294

    authors: Kessler RC,Stein MB,Bliese PD,Bromet EJ,Chiu WT,Cox KL,Colpe LJ,Fullerton CS,Gilman SE,Gruber MJ,Heeringa SG,Lewandowski-Romps L,Millikan-Bell A,Naifeh JA,Nock MK,Petukhova MV,Rosellini AJ,Sampson NA,Schoenbaum M,Za

    更新日期:2015-11-01 00:00:00

  • Recovery from chronic fatigue syndrome after treatments given in the PACE trial.

    abstract:BACKGROUND:A multi-centre, four-arm trial (the PACE trial) found that rehabilitative cognitive behaviour therapy (CBT) and graded exercise therapy (GET) were more effective treatments for chronic fatigue syndrome (CFS) than specialist medical care (SMC) alone, when each was added to SMC, and more effective than adaptiv...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1017/S0033291713000020

    authors: White PD,Goldsmith K,Johnson AL,Chalder T,Sharpe M

    更新日期:2013-10-01 00:00:00

  • Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

    abstract:BACKGROUND:There is evidence that patients with chronic fatigue syndrome (CFS) have mild hypocortisolism. The clinical significance of this is unclear. We aimed to determine whether hypocortisolism exerted any effect on the response of CFS to cognitive behavioural therapy (CBT). METHOD:We measured 24-h urinary free co...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709990390

    authors: Roberts AD,Charler ML,Papadopoulos A,Wessely S,Chalder T,Cleare AJ

    更新日期:2010-03-01 00:00:00

  • Influence of the noradrenergic system on the formation of intrusive memories in women: an experimental approach with a trauma film paradigm.

    abstract:BACKGROUND:Intrusive memories of traumatic events are a core feature of post-traumatic stress disorder but little is known about the neurobiological formation of intrusions. The aim of this study was to determine whether the activity of the noradrenergic system during an intrusion-inducing stressor would influence subs...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291716001379

    authors: Rombold F,Wingenfeld K,Renneberg B,Hellmann-Regen J,Otte C,Roepke S

    更新日期:2016-09-01 00:00:00

  • Psychological distress, physical illness and risk of myocardial infarction in the Caerphilly study.

    abstract:BACKGROUND:Studies have found associations between psychological distress (PD) and increased risk of myocardial infarction (MI). However, it is not clear whether the relationship reflects the subtle influence of pre-existing illness on both PD and MI. This study examines the association between PD and MI in a prospecti...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707000402

    authors: Rasul F,Stansfeld SA,Smith GD,Shlomo YB,Gallacher J

    更新日期:2007-09-01 00:00:00

  • Quality of life in chronically mentally ill patients in day treatment.

    abstract::A structured assessment instrument, the Quality of Life Interview, was used to explain the quality of life of seventy patients with chronic psychiatric illness attending a day treatment programme. The interview was found to have acceptable psychometric properties. Factors that best predicted the quality of life of the...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700017220

    authors: Levitt AJ,Hogan TP,Bucosky CM

    更新日期:1990-08-01 00:00:00

  • Altered corticostriatal functional connectivity in individuals with high social anhedonia.

    abstract:BACKGROUND:Dysregulation of the striatum and altered corticostriatal connectivity have been associated with psychotic disorders. Social anhedonia has been identified as a predictor for the development of schizophrenia spectrum disorders. The aim of the present study was to examine corticostriatal functional connectivit...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715001592

    authors: Wang Y,Liu WH,Li Z,Wei XH,Jiang XQ,Geng FL,Zou LQ,Lui SS,Cheung EF,Pantelis C,Chan RC

    更新日期:2016-01-01 00:00:00

  • The expressed emotion of case managers of the seriously mentally ill: the influence of expressed emotion on clinical outcomes.

    abstract:BACKGROUND:Expressed emotion (EE) measured from relatives and informal carers has been consistently demonstrated to be associated with clinical outcome in schizophrenic patients. There have also been published studies that have investigated EE in professional carers that have suggested that the quality of the relations...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291799001579

    authors: Tattan T,Tarrier N

    更新日期:2000-01-01 00:00:00

  • Estimating the incidence of first-episode psychosis using population-based health administrative data to inform early psychosis intervention services.

    abstract:BACKGROUND:Discrepancies between population-based estimates of the incidence of psychotic disorder and the treated incidence reported by early psychosis intervention (EPI) programs suggest additional cases may be receiving services elsewhere in the health system. Our objective was to estimate the incidence of non-affec...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718002933

    authors: Anderson KK,Norman R,MacDougall AG,Edwards J,Palaniyappan L,Lau C,Kurdyak P

    更新日期:2019-09-01 00:00:00

  • Concordance in the mental health of spouses: analysis of a large national household panel survey.

    abstract:BACKGROUND:Spousal concordance for common mental disorders provides evidence of the relevance of social contextual factors. There are, however, limitations within the existing literature examining spousal similarity in mental health and little consensus as to the causes of spousal similarity. This study considers a lar...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291705006677

    authors: Butterworth P,Rodgers B

    更新日期:2006-05-01 00:00:00

  • Familial confounding of the association between maternal smoking during pregnancy and internalizing disorders in offspring.

    abstract:BACKGROUND:Maternal smoking has consistently been associated with multiple adverse childhood outcomes including externalizing disorders. In contrast the association between maternal smoking during pregnancy (MSDP) and internalizing (anxiety and depressive) disorders in offspring has received less investigation. METHOD...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716003627

    authors: Meier SM,Plessen KJ,Verhulst F,Mors O,Mortensen PB,Pedersen CB,Agerbo E

    更新日期:2017-01-19 00:00:00

  • One-year outcome of unexplained fatigue syndromes in primary care: results from an international study.

    abstract:BACKGROUND:Outcome studies of chronic fatigue, neurasthenia and other unexplained fatigue syndromes are few and have been carried out in developed Western countries. This paper aimed to study the outcome of unexplained fatigue syndromes in an international primary care sample and to identify risk factors for persistenc...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1017/s0033291703007566

    authors: Skapinakis P,Lewis G,Mavreas V

    更新日期:2003-07-01 00:00:00

  • Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression.

    abstract:BACKGROUNDS:Cigarette smoking is strongly associated with major depressive disorder (MDD). However, any genetic etiology of such comorbidity and causal relations is poorly understood, especially at the genome-wide level. METHODS:In the present in silico research, we analyzed summary data from the genome-wide associati...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329172000063X

    authors: Yao Y,Xu Y,Cai Z,Liu Q,Ma Y,Li AN,Payne TJ,Li MD

    更新日期:2020-04-06 00:00:00

  • Comparison of psychotherapies for adult depression to pill placebo control groups: a meta-analysis.

    abstract:BACKGROUND:The effects of antidepressants for treating depressive disorders have been overestimated because of selective publication of positive trials. Reanalyses that include unpublished trials have yielded reduced effect sizes. This in turn has led to claims that antidepressants have clinically insignificant advanta...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析

    doi:10.1017/S0033291713000457

    authors: Cuijpers P,Turner EH,Mohr DC,Hofmann SG,Andersson G,Berking M,Coyne J

    更新日期:2014-03-01 00:00:00

  • Telephone-delivered psychosocial interventions targeting key health priorities in adults with a psychotic disorder: systematic review.

    abstract:BACKGROUND:The mental and physical health of individuals with a psychotic illness are typically poor. Access to psychosocial interventions is important but currently limited. Telephone-delivered interventions may assist. In the current systematic review, we aim to summarise and critically analyse evidence for telephone...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001125

    authors: Baker AL,Turner A,Beck A,Berry K,Haddock G,Kelly PJ,Bucci S

    更新日期:2018-12-01 00:00:00

  • Psychotic reactions to daily life stress and dopamine function in people with severe hearing impairment.

    abstract:BACKGROUND:Minor stresses measured in daily life have repeatedly been associated with increased momentary psychotic experiences, both in individuals with psychotic disorders and in persons who are genetically at an increased risk for these disorders. Severe hearing impairment (SHI) is an environmental risk factor for p...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291714002797

    authors: Gevonden MJ,Myin-Germeys I,van den Brink W,van Os J,Selten JP,Booij J

    更新日期:2015-06-01 00:00:00

  • Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder.

    abstract:BACKGROUND:In the conditioned fear paradigm, repeated pairing of an aversive unconditioned stimulus (US) (e.g. electric shock) with a neutral conditioned stimulus (CS) (e.g. bright light) results in a conditioned fear response to the light alone. Animal studies have shown that the amygdala plays a critical role in acqu...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291704003290

    authors: Bremner JD,Vermetten E,Schmahl C,Vaccarino V,Vythilingam M,Afzal N,Grillon C,Charney DS

    更新日期:2005-06-01 00:00:00

  • Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study.

    abstract:BACKGROUND:Obsessive-compulsive disorder (OCD) is a chronic, relapsing mental illness. Selective serotonin reuptake inhibitors block serotonin transporters (SERTs) and are the mainstay of treatment for OCD. SERT abnormalities are reported in drug-free patients with OCD, but it is not known what happens to SERT levels d...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715001865

    authors: Kim E,Howes OD,Park JW,Kim SN,Shin SA,Kim BH,Turkheimer FE,Lee YS,Kwon JS

    更新日期:2016-01-01 00:00:00

  • Factors related to successful outcome in the treatment of sexually unresponsive women.

    abstract::Couples in whom the main complaint was of a lack of female sexual response were treated using a practical counselling approach. A number of pre-treatment measures were studied to determine which factors were predictive of treatment outcome. While age and chronicity were not predictive, the quality of the general relat...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170000920x

    authors: Whitehead A,Mathews A

    更新日期:1986-05-01 00:00:00

  • Psychometric evaluation of the DSM-IV criterion B mania symptoms in an Australian national sample.

    abstract:BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291712000980

    authors: Carragher N,Weinstock LM,Strong D

    更新日期:2013-02-01 00:00:00

  • Parental mental illness and fatal birth defects in a national birth cohort.

    abstract:BACKGROUND:Few large studies describe links between maternal mental illness and risk of major birth defect in offspring. Evidence is sparser still for how effects vary between maternal diagnoses and no previous study has assessed risk with paternal illnesses. METHOD:A population-based birth cohort was created by linki...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707002280

    authors: Webb RT,Pickles AR,King-Hele SA,Appleby L,Mortensen PB,Abel KM

    更新日期:2008-10-01 00:00:00

  • Mental health problems in the Gomel region (Belarus): an analysis of risk factors in an area affected by the Chernobyl disaster.

    abstract::The epidemiology of mental problems in the Gomel region in the republic of Belarus was studied in a two-stage survey of a broad based population sample (N = 1617), using the General Health Questionnaire (12-item version) and the Munich Diagnostic Checklist for DSM-III-R. The Gomel region is one of the areas that was m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700037879

    authors: Havenaar JM,Van den Brink W,Van den Bout J,Kasyanenko AP,Poelijoe NW,Wholfarth T,Meijler-Iljina LI

    更新日期:1996-07-01 00:00:00

  • Psychosocial functioning among regular cannabis users with and without cannabis use disorder.

    abstract:BACKGROUND:In the United States, cannabis accessibility has continued to rise as the perception of its harmfulness has decreased. Only about 30% of regular cannabis users develop cannabis use disorder (CUD), but it is unclear if individuals who use cannabis regularly without ever developing CUD experience notable psych...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291717003361

    authors: Foster KT,Arterberry BJ,Iacono WG,McGue M,Hicks BM

    更新日期:2018-08-01 00:00:00

  • Dietary intake of fish and n-3 polyunsaturated fatty acids and risk of postpartum depression: a nationwide longitudinal study - the Japan Environment and Children's Study (JECS).

    abstract:BACKGROUND:Pregnant women require increased levels of n-3 polyunsaturated fatty acids (PUFAs) due to the demands of the growing fetus. Although some evidence indicates that maternal intake of fish and n-3 PUFAs is associated with reduced risk of postpartum depression, the results are inconsistent. METHODS:We investiga...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719002587

    authors: Hamazaki K,Matsumura K,Tsuchida A,Kasamatsu H,Tanaka T,Ito M,Inadera H,Japan Environment and Children's Study Group.

    更新日期:2020-10-01 00:00:00

  • Effect of propranolol and phenothiazines on electrodermal orienting and habituation in schizophrenia.

    abstract::Bilateral electrodermal orienting responses were measured to repeated auditory stimuli in schizophrenic patients and controls. In 3 studies phasic activity to moderate intensity sounds of patients on no drugs or phenothiazines was predominantly hyper- or hypo-responsive. Controls showed moderate or slow habituation. P...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700053319

    authors: Gruzelier J,Connolly J,Eves F,Hirsch S,Zaki S,Weller M,Yorkston N

    更新日期:1981-02-01 00:00:00

  • Co-morbidity and disorder-related distress and impairment in purging disorder.

    abstract:BACKGROUND:Recent studies suggest that purging disorder (PD) may be a common eating disorder that is associated with clinically significant levels of distress and high levels of psychiatric co-morbidity. However, no study has established evidence of disorder-related impairment or whether distress is specifically relate...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707001390

    authors: Keel PK,Wolfe BE,Gravener JA,Jimerson DC

    更新日期:2008-10-01 00:00:00

  • Temporal and right frontal lobe alterations in panic disorder: a quantitative volumetric and voxel-based morphometric MRI study.

    abstract:BACKGROUND:With regard to current neurobiological theories, the aim of our study was to examine possible alterations of temporal and frontal lobe volume in panic disorder (PD). METHOD:Seventeen in-patients with PD and a group of healthy control subjects (HC) matched for age and gender were investigated by quantitative...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709991930

    authors: Sobanski T,Wagner G,Peikert G,Gruhn U,Schluttig K,Sauer H,Schlösser R

    更新日期:2010-11-01 00:00:00

  • Brainstem glucose metabolism predicts reward dependence scores in treatment-resistant major depression.

    abstract:BACKGROUND:It has been suggested that individual differences in temperament could be involved in the (non-)response to antidepressant (AD) treatment. However, how neurobiological processes such as brain glucose metabolism may relate to personality features in the treatment-resistant depressed (TRD) state remains largel...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720005425

    authors: Wu GR,Baeken C

    更新日期:2021-01-28 00:00:00

  • The social causation of depression: a critique of the work of Brown and his colleagues.

    abstract::Brown and his colleagues have presented evidence for the social origins of depression from results of 2 community surveys in Camberwell. This paper examines critically their methodology, conceptualization of variables, mode of argument and statistical techniques. Log-linear analysis of their published data fails to su...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001878x

    authors: Tennant C,Bebbington P

    更新日期:1978-11-01 00:00:00