Abstract:
BACKGROUND:Suicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort. METHOD:Participants with major affective disorders in the National Institute of Mental Health (NIMH) Collaborative Depression Study (CDS) were followed prospectively for up to 25 years. A total of 909 participants meeting prospective diagnostic criteria for major depressive and bipolar disorders were followed through 4204 mood cycles. Suicidal behavior was defined as suicide attempts or completions. Mixed-effects, grouped-time survival analysis assessed risk of suicidal behavior and differential effects of risk factors for suicidal behavior by polarity. In addition to polarity, the main effects of age, gender, hopelessness, married status, prior suicide attempts and active substance abuse were modeled, with mood cycle as the unit of analysis. RESULTS:After controlling for age of onset, there were no differences in prior suicide attempts by polarity although bipolar participants had more prior severe attempts. During follow-up, 40 cycles ended in suicide and 384 cycles contained at least one suicide attempt. Age, hopelessness and active substance abuse but not polarity predicted suicidal behavior. The effects of risk factors did not differ by polarity. CONCLUSIONS:Bipolarity does not independently influence risk of suicidal behavior or alter the influence of well-established suicide risk factors within affective disorders. Suicide risk assessment strategies may continue to appraise these common risk factors without regard to mood polarity.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Fiedorowicz JG,Leon AC,Keller MB,Solomon DA,Rice JP,Coryell WHdoi
10.1017/S0033291708004078subject
Has Abstractpub_date
2009-05-01 00:00:00pages
763-71issue
5eissn
0033-2917issn
1469-8978pii
S0033291708004078journal_volume
39pub_type
杂志文章,多中心研究abstract:BACKGROUND:Previous research has found that depression is a major cause of memory complaints. However, there is evidence that memory complaints also weakly predict cognitive decline and dementia. The present study examined a range of possible determinants of memory complaints, covering psychiatric and personality facto...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003162
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Evidence from high-income countries suggests that childhood trauma is associated with schizophrenia. Studies of childhood trauma and schizophrenia in low and middle income (LMIC) countries are limited. This study examined the prevalence of childhood traumatic experiences among cases and controls and the rela...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001703
更新日期:2020-07-01 00:00:00
abstract::One week after Sir William Gull read his seminal report on anorexia nervosa to the Clinical Society of London, a brief account was published (Anonymous, 1873). In Paris, Charles Lasègue, editor of Archives Générales de Médecine read the report and printed an immediate editorial riposte, parts of which will be quoted i...
journal_title:Psychological medicine
pub_type: 传,历史文章,杂志文章
doi:10.1017/s0033291700030245
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Gulf War veterans have a number of health complaints. We therefore decided to carry out a systematic review to identify and summarize the findings from studies that have assessed multi-symptom conditions in Gulf War veterans and in an unexposed comparison group. METHOD:Studies published between January 1990...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S0033291705006975
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Generalized anxiety disorder (GAD) is highly co-morbid with depression. Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP), cross-sectionally and over time. To date, no studies have looked at the association between CRP and GAD. METHOD:A total of nine waves of ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000554
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Although impaired recognition of affective facial expressions has been conclusively linked to antisocial behavior, little is known about the modifiability of this deficit. This study investigated whether and under which circumstances the proposed perceptual insensitivity can be addressed with a brief implici...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713001517
更新日期:2014-04-01 00:00:00
abstract::The CAMCOG, the cognitive section of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX), was administered twice to 53 patients with a clinical diagnosis ranging from no dementia to severe dementia. The stability of the total CAMCOG score was high (0.97). Patients with less than moderate dementia we...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700039003
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001460
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Early Intervention in Psychosis Services (EIS) for young people in England experiencing first-episode psychosis (FEP) were commissioned in 2002, based on an expected incidence of 15 cases per 100 000 person-years, as reported by schizophrenia epidemiology in highly urban settings. Unconfirmed reports from EI...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002461
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:The coronavirus [coronavirus disease 2019 (COVID-19)] pandemic has introduced extraordinary life changes and stress, particularly in adolescents and young adults. Initial reports suggest that depression and anxiety are elevated during COVID-19, but no prior study has explored changes at the within-person lev...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720005358
更新日期:2021-01-13 00:00:00
abstract::The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic s...
journal_title:Psychological medicine
pub_type: 社论
doi:10.1017/s003329170500437x
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Men sexually interested in children of a specific combination of maturity and sex tend to show some lesser interest in other categories of persons. Patterns of men's sexual interest across erotic targets' categories of maturity and sex have both clinical and basic scientific implications. METHOD:We examined...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001476
更新日期:2020-06-01 00:00:00
abstract::The expressed emotion (EE) measure is a robust predictor of relapse in schizophrenia. At least twelve studies from a range of cultures have now shown this, although the authors of one maintain their findings are the result of confounding factors. A thirteenth study which failed to demonstrate a predictive effect was s...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700009831
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:It is unknown whether patient disengagement from early intervention services for psychosis is as prevalent in low- and middle-income countries (LMICs) like India, as it is in high-income countries (HICs). Addressing this gap, we studied two first-episode psychosis programs in Montreal, Canada and Chennai, In...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003359
更新日期:2020-09-28 00:00:00
abstract::The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034838
更新日期:1996-03-01 00:00:00
abstract::Ten depressed patients were assessed on an auditory signal detection task; testing was repeated on remission. The patients' clinical state was monitored by means of the Hamilton rating scale and the Beck Depression Inventory. The task was performed under three conditions: 2 button (Yes/No); 1 button (Yes); 1 button (N...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700006383
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Depression can impair the immunogenicity of vaccine administration in adults. Whereas many vaccinations are administered in childhood, it is not known whether adolescent or adult onset depression is associated with impairments in the maintenance of protection of childhood vaccines. This study tested the hypo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718000661
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Psychological models of conversion disorder (CD) traditionally assume that psychosocial stressors are identifiable around symptom onset. In the face of limited supportive evidence such models are being challenged. METHOD:Forty-three motor CD patients, 28 depression patients and 28 healthy controls were asse...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716000714
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703007475
更新日期:2003-05-01 00:00:00
abstract::One hundred and nineteen primiparae, who were routinely attending ante-natal clinics, were interviewed repeatedly between the 12th and 36th weeks of their pregnancies. The incidence of depression was highest in the first trimester and, overall, about a fifth of the sample was found to be suffering from clinically sign...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700018912
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Cognitive behaviour therapy (CBT) for chronic fatigue syndrome (CFS) leads to a significant decrease in CFS-related symptoms and disability. The primary objective of this study was to explore whether partners' solicitous responses and patients' and partners' perceived relationship satisfaction had an effect ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000288
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Multiple studies have found Conscientiousness to be protective against dementia. The purpose of this study is to identify which specific aspects, or facets, of Conscientiousness are most protective against cognitive impairment and whether these associations are moderated by demographic factors and/or genetic...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002306
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:The mental and physical health of individuals with a psychotic illness are typically poor. Access to psychosocial interventions is important but currently limited. Telephone-delivered interventions may assist. In the current systematic review, we aim to summarise and critically analyse evidence for telephone...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001125
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:We developed a comprehensive, 20-hour training programme for primary-care physicians, that sought to improve their ability to detect, diagnose and manage depression. We evaluated the effects of physician training on patient outcomes, using a pre-post design. METHODS:In the pre-training phase of the study, w...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799008545
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:Mild traumatic brain injury (mTBI) is being claimed as the 'signature' injury of the Iraq war, and is believed to be the cause of long-term symptomatic ill health (post-concussional syndrome; PCS) in an unknown proportion of military personnel. METHOD:We analysed cross-sectional data from a large, randomly ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708004595
更新日期:2009-08-01 00:00:00
abstract::Recent studies have suggested that expanded CAG/CTG repeats contribute to the genetic aetiology of schizophrenia and bipolar disorder. However, the nature of this contribution is uncertain and difficult to predict from other known trinucleotide repeat diseases that display much simpler patterns of inheritance. We have...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035868
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood. METHODS:We...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000801
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Rumination is an important cognitive risk factor for onset and relapse of depression. However, no studies have employed a dimensional approach in investigating the neural correlates of rumination and the relationship with depression. METHOD:Non-clinical healthy subjects (n = 306), who completed the classica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000938
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Cannabis use is associated with altered neurocognitive functioning in severe mental disorders, but data are still inconclusive and there are no studies of bipolar disorder. The aim of this study was to investigate the association between cannabis use and neurocognition in bipolar disorder compared with schiz...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991620
更新日期:2010-08-01 00:00:00
abstract::A non-recursive structural equation model designed to examine the reciprocal relationship between life event reports and depressive symptoms in women is presented. The model was fitted to data from a 2-year longitudinal study of life events and depression in a sample of women with 5-year-old children. The findings sug...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001984x
更新日期:1984-11-01 00:00:00