Abstract:
:The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic subtype, respond with marked improvement within hours. Treatment can be a single or repeated sleep deprivation, total (all night) or partial (second half of the night). Relapse can be prevented by daily light therapy, concomitant administration of SSRIs, lithium (for bipolar patients), or a short phase advance of sleep over 3 days following a single night of wake therapy. Combinations of these interventions show great promise. (2) Light therapy is effective for major depression--not only for the seasonal subtype. As an adjuvant to conventional antidepressants in unipolar patients, or lithium in bipolar patients, morning light hastens and potentiates the antidepressant response. Light therapy shows benefit even for patients with chronic depression of 2 years or more, outperforming their weak response to drugs. This method provides a viable alternative for patients who refuse, resist or cannot tolerate medication, or for whom drugs may be contraindicated, as in antepartum depression. (3) Given the urgent need for new strategies to treat patients with residual depressive symptoms, clinical trials of wake therapy and/or adjuvant light therapy, coupled with follow-up studies of long-term recurrence, are a high priority.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Wirz-Justice A,Benedetti F,Berger M,Lam RW,Martiny K,Terman M,Wu JCdoi
10.1017/s003329170500437xsubject
Has Abstractpub_date
2005-07-01 00:00:00pages
939-44issue
7eissn
0033-2917issn
1469-8978journal_volume
35pub_type
社论abstract:OBJECTIVE:The goal of this study is to determine the association between panic attacks in adolescence and the risk of personality disorders during young adulthood. METHOD:Data were drawn from the Children in the Community Study, a longitudinal epidemiological study of psychopathology across the life-course in 717 indi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003319
更新日期:2005-02-01 00:00:00
abstract::The age of onset in bipolar affective disorder was determined in 200 hospitalized patients. The mean age of their first affective syndrome was 28.3 years, and the mean age of first hospitalization was 30.8 years. However, the median age for first affective syndrome was 23 years (26 years for first hospitalization), an...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003147
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:The effect of prenatal distress on the risk of a small for gestational age (SGA) infant is uncertain. We have addressed the influences of prenatal stress, anxiety and depression on the risk of SGA. We also examined the effects of infant sex and timing of distress during pregnancy on any observed associations...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714000300
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Factor analysis has been employed to identify latent variables that are unifying constructs and that parsimoniously describe correlations among a related group of variables. Confirmatory factor analysis is used to test hypothesized factor structures for a set of variables; it can also, as in this paper be us...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797005710
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Cognitive behaviour therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) but access to CBT is limited. Internet-based CBT (ICBT) with therapist support is potentially a more accessible treatment. There are no randomized controlled trials testing ICBT for OCD. The aim of this study ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291712000244
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Individual variation in the clinical course of bipolar disorder may have prognostic and therapeutic implications but is poorly reflected in current classifications. We aimed to establish a typology of the individual clinical trajectories based on detailed prospective medium-term follow-up. Method Latent clas...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001523
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Despite the demonstrable influence of both genes and the family environment on children's behavioural and emotional development, the mechanisms by which these factors are transmitted from parents to their children are not known. Numerous aspects of the family have long been associated with behavioural and em...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703008948
更新日期:2004-02-01 00:00:00
abstract::The factor structure of the 60-item version of the General Health Questionnaire was explored, using data collected in a community study in a rural area of northern Spain. Six principal components, similar to those previously reported with this instrument, were found to provide a good description of the data structure....
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700002038
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Schizophrenia patients have a higher prevalence of type 2 diabetes mellitus with impaired glucose tolerance (IGT) than normals. We examined the relationship between IGT and clinical phenotypes or cognitive deficits in first-episode, drug-naïve (FEDN) Han Chinese patients with schizophrenia. METHOD:A total o...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001902
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001976
更新日期:2019-07-01 00:00:00
abstract::Primiparae were randomly assigned to two conditions of routine ultrasound examination at their first antenatal clinic visit: (a) high feedback ultrasound where the monitor screen was visible and the patient was shown the foetal size, shape and movement (N = 67); (b) low feedback ultrasound where the screen was not see...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291700046717
更新日期:1982-05-01 00:00:00
abstract:BACKGROUND:Neuroimaging studies have shown variance in brain response to emotional faces predicts cognitive behavioral therapy (CBT) outcome. An important next step is to determine if individual differences in neural predictors of CBT response represent distinct patient groups. METHODS:In total, 90 patients with inter...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003979
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied. METHOD:The three key cognitive symptoms of worthle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713000160
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:Most evidence in the UK on the effectiveness of brief therapy for depression concerns cognitive behaviour therapy (CBT). In a trial published in 2000, we showed that non-directive counselling and CBT were equally effective in general practice for patients with depression and mixed anxiety and depression. Our...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291713002377
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Trans and gender diverse (TGD) young people worldwide experience high rates of poor mental health; however, these rates were unknown in Australia. In addition, how negative life events affect the mental health of TGD young people has been largely unexplored. METHODS:This paper reports on novel mental health...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000643
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:In the present paper, sex differences in the association between adult depression and childhood experiences were examined. METHODS:The study series of the Finnish UKKI Study consisted of a population sample of 501 men and 499 women. Information concerning childhood experiences was gathered retrospectively i...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006089
更新日期:1998-01-01 00:00:00
abstract::Social anxiety disorder is one of the most common comorbid conditions in eating disorders (EDs). The aim of the current review and meta-analysis is to provide a qualitative summary of what is known about social anxiety (SA) in EDs, as well as to compare levels of SA in those with EDs and healthy controls. Electronic d...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291718000752
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:UK veterans suffering from a psychological or psychiatric illness as a consequence of service in the Second World War were entitled to a war pension. Their case files, which include regular medical assessments, are a valuable resource to investigate the nature, distribution and duration of symptoms. METHODS...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001460
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Research on the subject of insight has been hampered by difficulties in definition and reliable measurement. METHODS:We compared several rating scales to measure insight on a group of 33 psychotic patients as well as assessing patients' psychopathology, clinical characteristics and cognitive functioning. R...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291797006296
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Several lines of evidence indicate a role of the brain-derived neurotrophic factor (BDNF) in the modulation of eating behaviour. Therefore, alterations in the physiology of this neurotrophin may be involved in the pathogenesis of eating disorders. In the present study, we investigated serum levels of BDNF in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291704003368
更新日期:2005-06-01 00:00:00
abstract::In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700023163
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:The salience of a visual stimulus is often reduced by nearby stimuli, an effect known as surround suppression of perceived contrast, which may help in locating the borders of an object. Weaker surround suppression has been observed in schizophrenia but it is unclear whether this abnormality is present in oth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715001439
更新日期:2015-12-01 00:00:00
abstract::The value of services for those with the 'At Risk Mental State for Psychosis' (ARMS) continues to be disputed. ARMS services have provided a valuable stimulus to academic research into the transition into psychosis. Furthermore, there is currently a welcome trend to transform such clinics into youth mental health serv...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329172000313X
更新日期:2020-09-07 00:00:00
abstract:BACKGROUND:Retrospective studies have consistently indicated an association between maladaptive parenting and borderline personality disorder (BPD). This requires corroboration with prospective, longitudinal designs. We investigated the association between suboptimal parenting and parent conflict in childhood and BPD s...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000542
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Nitric oxide synthase (NOS) activity, an enzyme potentially involved in the major depressive episodes (MDE), could be indirectly measured by the L-Citrulline/L-Arginine ratio (L-Cit/L-Arg). The aim of this study was: (1) to compare the NOS activity of patients with a MDE to that of healthy controls (HC); (2)...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720001749
更新日期:2020-06-11 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003598
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:The effectiveness of therapeutic interventions in psychosis is increasingly reported in terms of reductions in different symptom dimensions. It remains unclear, however, to what degree such symptomatic changes are accompanied by improvement in other measures such as service use, quality of life, and needs fo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799001014
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Assortative mating has been demonstrated in mental disorders but the extent of cohabitation between patients with clinically diagnosed psychiatric disease has been poorly explored. Method We conducted a register-based study of all Danes between 18 and 70 years of age in a 13-year observational period, linkin...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329171200181X
更新日期:2013-05-01 00:00:00
abstract::Using the 40-item Eating Attitudes Test and other self-report questions, a two-stage screening survey of 1020 (F 646, M 374) Chinese bilingual university students in Hong Kong showed that although female students were 'underweight' by Western standard, the majority of them and nearly all female students above a body m...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700028531
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Alcohol is commonly considered to be associated with persistence of common mental disorder (CMD; anxiety/depression). However no community-based longitudinal studies have investigated the direction of causality. METHOD:We examined the association between alcohol consumption and recovery from CMD using data ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707002000
更新日期:2008-03-01 00:00:00