当前位置： SCI文献检索 > PSYCHOLOGICAL MEDICINE期刊下所有文献 > Second-trimester maternal distress increases the risk of small for gestational age.

Second-trimester maternal distress increases the risk of small for gestational age.

Abstract：

BACKGROUND:The effect of prenatal distress on the risk of a small for gestational age (SGA) infant is uncertain. We have addressed the influences of prenatal stress, anxiety and depression on the risk of SGA. We also examined the effects of infant sex and timing of distress during pregnancy on any observed associations. METHOD:The study population comprised 5606 healthy nulliparous pregnant women who participated in the international prospective Screening for Obstetric and Pregnancy Endpoints (SCOPE) study. Women completed the Perceived Stress Scale (PSS), the short form of the Spielberger State-Trait Anxiety Inventory (STAI) and the Edinburgh Postnatal Depression Scale (EPDS) at 15 ± 1 and 20 ± 1 weeks' gestation. SGA was defined as birthweight below the 10th customized percentile. Logistic regression was used for data analysis, adjusting for several potential confounders such as maternal age, body mass index (BMI), smoking, socio-economic status and physical exercise. RESULTS:The risk of SGA was increased in relation to mild [adjusted odds ratio (aOR) 1.35, 95% confidence interval (CI) 1.07-1.71], moderate (aOR 1.26, 95% CI 1.06-1.49), high (aOR 1.45, 95% CI 1.08-1.95) and very high stress scores (aOR 1.56, 95% CI 1.03-2.37); very high anxiety score (aOR 1.45, 95% CI 1.13-1.86); and very high depression score (aOR 1.14, 95% CI 1.05-1.24) at 20 ± 1 weeks' gestation. Sensitivity analyses showed that very high anxiety and very high depression increases the risk of SGA in males but not in females whereas stress increases the risk of SGA in both males and females. CONCLUSIONS:These findings suggest that prenatal stress, anxiety and depression measured at 20 weeks' gestation increase the risk of SGA. The effects of maternal anxiety and depression on SGA were strongest in male infants.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Khashan AS,Everard C,McCowan LM,Dekker G,Moss-Morris R,Baker PN,Poston L,Walker JJ,Kenny LC

doi

10.1017/S0033291714000300

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

2799-810

issue

eissn

0033-2917

issn

1469-8978

pii

S0033291714000300

journal_volume

pub_type

杂志文章

在线工具

Second-trimester maternal distress increases the risk of small for gestational age.