Abstract:
BACKGROUND:Cognitive behaviour therapy (CBT) is an effective treatment for obsessive-compulsive disorder (OCD) but access to CBT is limited. Internet-based CBT (ICBT) with therapist support is potentially a more accessible treatment. There are no randomized controlled trials testing ICBT for OCD. The aim of this study was to investigate the efficacy of ICBT for OCD in a randomized controlled trial. METHOD:Participants (n=101) diagnosed with OCD were randomized to either 10 weeks of ICBT or to an attention control condition, consisting of online supportive therapy. The primary outcome measure was the Yale-Brown Obsessive Compulsive Scale (YBOCS) administered by blinded assessors. RESULTS:Both treatments lead to significant improvements in OCD symptoms, but ICBT resulted in larger improvements than the control condition on the YBOCS, with a significant between-group effect size (Cohen's d) of 1.12 (95% CI 0.69-1.53) at post-treatment. The proportion of participants showing clinically significant improvement was 60% (95% CI 46-72) in the ICBT group compared to 6% (95% CI 1-17) in the control condition. The results were sustained at follow-up. CONCLUSIONS:ICBT is an efficacious treatment for OCD that could substantially increase access to CBT for OCD patients. Replication studies are warranted.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Andersson E,Enander J,Andrén P,Hedman E,Ljótsson B,Hursti T,Bergström J,Kaldo V,Lindefors N,Andersson G,Rück Cdoi
10.1017/S0033291712000244subject
Has Abstractpub_date
2012-10-01 00:00:00pages
2193-203issue
10eissn
0033-2917issn
1469-8978pii
S0033291712000244journal_volume
42pub_type
杂志文章,随机对照试验abstract:BACKGROUND:The objective was to describe patients presenting themselves at emergency-care settings following a suicide attempt in eight culturally different sites [Campinas (Brazil), Chennai (India), Colombo (Sri Lanka), Durban (South Africa), Hanoi (Viet Nam), Karaj (Iran), Tallinn (Estonia), and Yuncheng, (China)]. ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291705005416
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S0033291713000949
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. METHOD:Antidepressant use and work-related injuries between ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715002925
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Morphometric endophenotypes which have been proposed for psychotic disorders include lateral ventricular enlargement and hippocampal volume reductions. Genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes have been implica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709990316
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:This study examined healthcare services used by adults diagnosed with an eating disorder (ED) in a large health maintenance organization in the Pacific Northwest. METHOD:Electronic medical records were used to collect information on all out-patient and in-patient visits and medication dispenses, from 2002 t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001833
更新日期:2008-10-01 00:00:00
abstract::This paper analyses patterns of episodes of anxiety and depression as recorded by 22 general practices which took part in the Second National Morbidity Survey (RCGP, 1980). The data comprise 6 years' records. Simple Markov chains are fitted to each age-group of men and women, and the inter-practice variation in the re...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700051643
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:The aim of the study was to determinate whether schizophrenia patients with a history of cannabis use have a different prognosis, with regards to readmission and hospital duration, compared with those without a history of cannabis use. METHOD:The present investigation was a cohort study of 50,087 Swedish me...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714000191
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Social cognition has been associated with functional outcome in patients with first episode psychosis (FEP). Social cognition has also been associated with neurocognition and cognitive reserve. Although cognitive reserve, neurocognitive functioning, social cognition, and functional outcome are related, the d...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002794
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Mental disorders often begin during the formative years of education. They may disrupt education and lead to social underachievement. METHODS:We examined the impact of mental disorders treated in hospital (ages 16-29) on educational attainment up to 31 years in the Northern Finland 1966 Birth Cohort (N = 10...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170100304x
更新日期:2001-02-01 00:00:00
abstract::We found diurnal weight gain to be abnormal among 28 institutionalized chronically psychotic patients. They were weighed daily for 15 days at 7 a.m. and 4 p.m. We normalized the diurnal weight gain (NDWG) as a percentage by subtracting the 7 a.m. weight from the 4 p.m. weight, multiplying the difference by 100, and th...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700011065
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Neuroticism has been shown to increase the risk of depression whereas extraversion is associated with a reduction of risk. These personality traits play a central role in aetiological theories of affective disorder but their role in schizophrenia is unclear. In this study, the risk for schizophrenia associat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701004044
更新日期:2001-08-01 00:00:00
abstract:BACKGROUND:With regard to current neurobiological theories, the aim of our study was to examine possible alterations of temporal and frontal lobe volume in panic disorder (PD). METHOD:Seventeen in-patients with PD and a group of healthy control subjects (HC) matched for age and gender were investigated by quantitative...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291709991930
更新日期:2010-11-01 00:00:00
abstract::The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to a...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700000611
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personality traits is ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712001997
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Mental health morbidity in post-conflict settings is high. Nevertheless, randomized controlled trials of psychotherapy on site are rare. Our aim was to integrate rigorous research procedures into a humanitarian programme and test the efficacy of resource activation (ROTATE) in treating post-traumatic stress ...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291716002592
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied. METHOD:The three key cognitive symptoms of worthle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291713000160
更新日期:2013-11-01 00:00:00
abstract::Five idiots savants whose artistic output was judged to be at art school entrance standard were matched for performance and verbal IQ with control subjects who had no special artistic talent. Each subject was given tests of reproductive skill with both concrete pictures and unfamiliar and unnameable geometric designs....
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700013003
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:Preclinical and human studies suggest an association between chronic inflammation and the development of depressive behaviors. This is proposed to occur through downstream effects of inflammatory cytokines on neuroplasticity, neurogenesis and neurotransmitter function, although the neural correlates remain p...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719002940
更新日期:2020-12-01 00:00:00
abstract::The present study examined sensitivity to noise in subjects with Type A and Type B behaviour patterns as a function of the type of task being performed. Twenty Type A and 20 Type B subjects, selected by means of Bortner's scale (French version), were exposed to steadily increasing noise levels (68-110 dBA) while perfo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700015245
更新日期:1984-08-01 00:00:00
abstract:BACKGROUND:We examined the prevalence of self-perceived respiratory symptoms (SRS) in the absence of any objective findings of respiratory pathology, and the association of such prevalence with psychological factors and healthcare use in the general population. METHODS:The study was conducted among a nationally repres...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718000582
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Major depressive disorder (MDD) is accompanied by alterations in grey matter volume. However, the biological processes associated with regional structural perturbations remain elusive. METHODS:We applied integrative omics analysis to investigate specialized transcriptome signatures and translational determi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002676
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Although the traditional view of bipolar affective disorder is that the majority of patients have full remission between episodes, recent evidence suggests that residual cognitive deficits are present. The aim of this study was to determine whether memory and executive deficits were present in a well-defined...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002664
更新日期:2000-09-01 00:00:00
abstract::This study examined the relationship between personality factors and depression in subjects who may have a familial vulnerability to depression (i.e. first-degree relatives of depressed patients). Four groups comprised our study sample: relatives who had never experienced a psychiatric episode of depression; relatives...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700013052
更新日期:1987-02-01 00:00:00
abstract::Individuals with high and low susceptibility to hypnosis were compared in a baseline condition and after instructions of hypnosis on tests of anterior left and right hemispheric functions--word fluency to letter categories, word fluency to semantic categories, design fluency and bilateral finger tapping dexterity. Wit...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700038885
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707000530
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Recent studies suggest that purging disorder (PD) may be a common eating disorder that is associated with clinically significant levels of distress and high levels of psychiatric co-morbidity. However, no study has established evidence of disorder-related impairment or whether distress is specifically relate...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291707001390
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:In people with bulimic eating disorders, exposure to high-calorie foods can result in increases in food craving, raised subjective stress and salivary cortisol concentrations. This cue-induced food craving can be reduced by repetitive transcranial magnetic stimulation (rTMS). We investigated whether rTMS has...
journal_title:Psychological medicine
pub_type: 杂志文章,随机对照试验
doi:10.1017/S0033291710001881
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:In schizophrenia, affective disorders, and obsessive-compulsive disorder (OCD) dysfunction of frontal neuronal circuits has been suggested. Such impairments imply corresponding oculomotor deficits. METHOD:Eye movement response to foveofugal and foveopetal step-ramp stimuli was recorded within the same study...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291703001314
更新日期:2004-04-01 00:00:00
abstract:BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291712000980
更新日期:2013-02-01 00:00:00
abstract::The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002172
更新日期:2020-08-01 00:00:00