The relationship between childhood trauma and schizophrenia in the Genomics of Schizophrenia in the Xhosa people (SAX) study in South Africa.

Abstract:

BACKGROUND:Evidence from high-income countries suggests that childhood trauma is associated with schizophrenia. Studies of childhood trauma and schizophrenia in low and middle income (LMIC) countries are limited. This study examined the prevalence of childhood traumatic experiences among cases and controls and the relationship between specific and cumulative childhood traumatic experiences and schizophrenia in a sample in South Africa. METHODS:Data were from the Genomics of Schizophrenia in the South African Xhosa people study. Cases with schizophrenia and matched controls were recruited from provincial hospitals and clinics in the Western and Eastern Cape regions in South Africa. Childhood traumatic experiences were measured using the Childhood Trauma Questionnaire (CTQ). Adjusted logistic regression models estimated associations between individual and cumulative childhood traumatic experiences and schizophrenia. RESULTS:Traumatic experiences were more prevalent among cases than controls. The odds of schizophrenia were 2.44 times higher among those who experienced any trauma than those who reported no traumatic experiences (95% CI 1.77-3.37). The odds of schizophrenia were elevated among those who experienced physical/emotional abuse (OR 1.59, CI 1.28-1.97), neglect (OR 1.39, CI 1.16-1.68), and sexual abuse (OR 1.22, CI 1.03-1.45) compared to those who did not. Cumulative physical/emotional abuse and neglect experiences increased the odds of schizophrenia as a dose-response relationship. CONCLUSION:Childhood trauma is common in this population. Among many other benefits, interventions to prevent childhood trauma may contribute to a decreasing occurrence of schizophrenia.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Mall S,Platt JM,Temmingh H,Musenge E,Campbell M,Susser E,Stein DJ

doi

10.1017/S0033291719001703

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1570-1577

issue

9

eissn

0033-2917

issn

1469-8978

pii

S0033291719001703

journal_volume

50

pub_type

杂志文章
  • Variations in referral pattern to the psychiatric services by general practitioners.

    abstract::Referral rates to psychiatric services in North-East Scotland by 147 individual urban and rural general practitioners were calculated. Among city doctors, the greater the number of years since qualification the more patients were referred. Single-handed city doctors also had very high referral rates. Subsequent interv...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700030865

    authors: Robertson NC

    更新日期:1979-05-01 00:00:00

  • Attributes of long-term heavy cannabis users: a case-control study.

    abstract:BACKGROUND:Although cannabis is the most widely used illicit drug in the United States, few recent American studies have examined the attributes of long-term heavy cannabis users. METHOD:Using a case-control design, we obtained psychological and demographic measures on 108 individuals, age 30-55, who had smoked cannab...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703008560

    authors: Gruber AJ,Pope HG,Hudson JI,Yurgelun-Todd D

    更新日期:2003-11-01 00:00:00

  • Psychosis breakthrough on antipsychotic maintenance: results from a nationwide study.

    abstract:BACKGROUND:There is uncertainty about the incidence of breakthrough psychosis in treatment adherent patients, and the role that factors, such as cumulative antipsychotic exposure, play in this phenomenon. METHODS:In a nationwide cohort of individuals treated for schizophrenia-spectrum disorders in Finland between 1 Ja...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719001296

    authors: Rubio JM,Taipale H,Correll CU,Tanskanen A,Kane JM,Tiihonen J

    更新日期:2020-06-01 00:00:00

  • Differential motivational responses to food and pleasurable cues in anorexia and bulimia nervosa: a startle reflex paradigm.

    abstract:BACKGROUND:Abnormal perceptions of food and shape underpin the cognitive behavioural model of eating disorders (EDs). The aim of this study was to investigate motivational processing of disorder-specific and standard emotional cues in anorexia (AN) and bulimia nervosa (BN) using startle eyeblink modulation (SEM). SEM w...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706008129

    authors: Friederich HC,Kumari V,Uher R,Riga M,Schmidt U,Campbell IC,Herzog W,Treasure J

    更新日期:2006-09-01 00:00:00

  • Biased attention to threat in paediatric anxiety disorders (generalized anxiety disorder, social phobia, specific phobia, separation anxiety disorder) as a function of 'distress' versus 'fear' diagnostic categorization.

    abstract:BACKGROUND:Structural models of emotional disorders propose that anxiety disorders can be classified into fear and distress disorders. Sources of evidence for this distinction come from genetic, self-report and neurophysiological data from adults. The present study examined whether this distinction relates to cognitive...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291713000779

    authors: Waters AM,Bradley BP,Mogg K

    更新日期:2014-02-01 00:00:00

  • Stratum-specific likelihood ratios of two versions of the general health questionnaire.

    abstract:BACKGROUND:In other branches of epidemiology, stratum specific likelihood ratios (SSLRs) have been found to be preferable to fixed best threshold approaches to screening instruments. This paper presents SSLRs of GHQ-12 and GHQ-28 and compares the SSLR method with the traditional optimal threshold approach. METHODS:Ran...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,多中心研究

    doi:10.1017/s0033291701003713

    authors: Furukawa TA,Goldberg DP,Rabe-Hesketh S,Ustün TB

    更新日期:2001-04-01 00:00:00

  • Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men.

    abstract:BACKGROUND:Genetic influences on alcoholism risk are well-documented in men, but uncertain in women. We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD). METHOD:Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Austra...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291797005643

    authors: Heath AC,Bucholz KK,Madden PA,Dinwiddie SH,Slutske WS,Bierut LJ,Statham DJ,Dunne MP,Whitfield JB,Martin NG

    更新日期:1997-11-01 00:00:00

  • Childhood adversity and psychosis: a systematic review of bio-psycho-social mediators and moderators.

    abstract::The association between childhood adversity (CA) and psychosis has been extensively investigated in recent years. An increasing body of research has also focused on the mediating or moderating role of biological and psychological mechanisms, as well as other risk factors that might account for the link between CA and ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720002172

    authors: Sideli L,Murray RM,Schimmenti A,Corso M,La Barbera D,Trotta A,Fisher HL

    更新日期:2020-08-01 00:00:00

  • Behavioral preference for viewing drug v. pleasant images predicts current and future opioid misuse among chronic pain patients.

    abstract:BACKGROUND:The USA is currently enduring an opioid crisis. Identifying cost-effective, easy-to-implement behavioral measures that predict treatment outcomes in opioid misusers is a crucial scientific, therapeutic, and epidemiological goal. METHODS:The current study used a mixed cross-sectional and longitudinal design ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719000461

    authors: Moeller SJ,Hanley AW,Garland EL

    更新日期:2020-03-01 00:00:00

  • Prevalence and determinants of cognitive impairment in the euthymic phase of bipolar disorders: results from the FACE-BD cohort.

    abstract:BACKGROUND:Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001186

    authors: Roux P,Etain B,Cannavo AS,Aubin V,Aouizerate B,Azorin JM,Bellivier F,Belzeaux R,Bougerol T,Cussac I,Courtet P,Kahn JP,Leboyer M,M'Bailara K,Payet MP,Olié E,FondaMental Advanced Centers of Expertise in Bipolar Disorders (F

    更新日期:2019-02-01 00:00:00

  • Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.

    abstract::Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinic...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715001609

    authors: Noda Y,Silverstein WK,Barr MS,Vila-Rodriguez F,Downar J,Rajji TK,Fitzgerald PB,Mulsant BH,Vigod SN,Daskalakis ZJ,Blumberger DM

    更新日期:2015-12-01 00:00:00

  • Neuroticism in familial depression.

    abstract::This study examined the relationship between personality factors and depression in subjects who may have a familial vulnerability to depression (i.e. first-degree relatives of depressed patients). Four groups comprised our study sample: relatives who had never experienced a psychiatric episode of depression; relatives...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700013052

    authors: Katz R,McGuffin P

    更新日期:1987-02-01 00:00:00

  • Symptoms of post-traumatic stress disorder, severe psychological distress, explosive anger and grief amongst partners of survivors of high levels of trauma in post-conflict Timor-Leste.

    abstract:BACKGROUND:Little is known about the mental health of partners of survivors of high levels of trauma in post-conflict countries. METHOD:We studied 677 spouse dyads (n = 1354) drawn from a community survey (response 82.4%) in post-conflict Timor-Leste. We used culturally adapted measures of post-traumatic stress disord...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716002233

    authors: Silove DM,Tay AK,Steel Z,Tam N,Soares Z,Soares C,Dos Reis N,Alves A,Rees S

    更新日期:2017-01-01 00:00:00

  • Neuroanatomical abnormalities in first-episode psychosis across independent samples: a multi-centre mega-analysis.

    abstract:BACKGROUND:Neuroanatomical abnormalities in first-episode psychosis (FEP) tend to be subtle and widespread. The vast majority of previous studies have used small samples, and therefore may have been underpowered. In addition, most studies have examined participants at a single research site, and therefore the results m...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291719003568

    authors: Vieira S,Gong Q,Scarpazza C,Lui S,Huang X,Crespo-Facorro B,Tordesillas-Gutierrez D,de la Foz VO,Setien-Suero E,Scheepers F,van Haren NEM,Kahn R,Reis Marques T,Ciufolini S,Di Forti M,Murray RM,David A,Dazzan P,McGuire

    更新日期:2019-12-20 00:00:00

  • Inhibitory deficits for negative information in persons with major depressive disorder.

    abstract:BACKGROUND:Within Beck's cognitive model of depression, little is known about the mechanism(s) by which activated self-schemas result in the production of negative thoughts. Recent research has demonstrated that inhibitory dysfunction is present in depression, and this deficit is likely valence-specific. However, wheth...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291707000530

    authors: Lau MA,Christensen BK,Hawley LL,Gemar MS,Segal ZV

    更新日期:2007-09-01 00:00:00

  • Rapid tranquillisation in a psychiatric emergency hospital in Lebanon: TREC-Lebanon - a pragmatic randomised controlled trial of intramuscular haloperidol and promethazine v. intramuscular haloperidol, promethazine and chlorpromazine.

    abstract:BACKGROUND:Agitated patients constitute 10% of all emergency psychiatric treatment. Management guidelines, the preferred treatment of clinicians differ in opinion and practice. In Lebanon, the use of the triple therapy haloperidol plus promethazine plus chlorpromazine (HPC) is frequently used but no studies involving t...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720004869

    authors: Dib JE,Yaacoub HE,Ikdais WH,Atallah E,Merheb TJ,Ajaltouni J,Akkari M,Mourad M,Nasr ME,Hachem D,Kazour F,Tahan F,Haddad G,Azar J,Zoghbi M,Haddad C,Hallit S,Adams CE

    更新日期:2021-01-06 00:00:00

  • The general practitioner as the first contacted health professional by patients with psychosocial problems: a European study.

    abstract:BACKGROUND:There are considerable differences between and within countries in the involvement of general practitioners (GPs) in psychosocial care. This study aimed to describe the self-perceived role of GPs in 30 European countries as the first contacted professional for patients with psychosocial problems. and to exam...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329179900851x

    authors: Boerma WG,Verhaak PF

    更新日期:1999-05-01 00:00:00

  • Symptom dimensions and cognitive and social functioning in recent-onset schizophrenia.

    abstract::The relationships among symptoms, cognitive functioning and social functioning were investigated in 60 patients with recent-onset schizophrenia. Positive symptoms were unrelated to cognitive measures. Disorganization and depressive symptoms were correlated significantly with Card Sorting performance. Furthermore, only...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700025514

    authors: Van der Does AJ,Dingemans PM,Linszen DH,Nugter MA,Scholte WF

    更新日期:1993-08-01 00:00:00

  • Kleptomania: clinical characteristics and associated psychopathology.

    abstract::A review of research on kleptomania--the syndrome of compulsive stealing--suggests that kleptomania may be a common disorder, especially among women, and that it may frequently be associated with other forms of psychopathology, such as mood, anxiety, and eating disorders. There appears to be a range of abnormal or non...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700014690

    authors: McElroy SL,Hudson JI,Pope HG,Keck PE

    更新日期:1991-02-01 00:00:00

  • Occupational differences in US Army suicide rates.

    abstract:BACKGROUND:Civilian suicide rates vary by occupation in ways related to occupational stress exposure. Comparable military research finds suicide rates elevated in combat arms occupations. However, no research has evaluated variation in this pattern by deployment history, the indicator of occupation stress widely consid...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715001294

    authors: Kessler RC,Stein MB,Bliese PD,Bromet EJ,Chiu WT,Cox KL,Colpe LJ,Fullerton CS,Gilman SE,Gruber MJ,Heeringa SG,Lewandowski-Romps L,Millikan-Bell A,Naifeh JA,Nock MK,Petukhova MV,Rosellini AJ,Sampson NA,Schoenbaum M,Za

    更新日期:2015-11-01 00:00:00

  • Slow binocular rivalry in bipolar disorder.

    abstract:BACKGROUND:The rate of binocular rivalry has been reported to be slower in subjects with bipolar disorder than in controls when tested with drifting, vertical and horizontal gratings of high spatial frequency. METHOD:Here we assess the rate of binocular rivalry with stationary, vertical and horizontal gratings of low ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291703007475

    authors: Miller SM,Gynther BD,Heslop KR,Liu GB,Mitchell PB,Ngo TT,Pettigrew JD,Geffen LB

    更新日期:2003-05-01 00:00:00

  • The causal nature of the association between resting pulse in late adolescence and risk for internalizing and externalizing disorders: a co-relative analysis in a national male Swedish sample.

    abstract:BACKGROUND:Resting pulse is robustly and inversely associated with the risk for externalizing disorders and may be positively associated with internalizing disorders. We know little about the causal nature of these associations. METHODS:We examined resting pulse at conscription examination in 369 301 males born 1960-8...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720000549

    authors: Kendler KS,Lönn SL,Sundquist J,Sundquist K

    更新日期:2020-03-24 00:00:00

  • Differentiation between mild cognitive impairment, Alzheimer's disease and depression by means of cued recall.

    abstract:BACKGROUND:Discriminating Alzheimer's disease (AD) and mild cognitive impairment (MCI) from depression is a challenge in psychogeriatric medicine. A study was set up to ascertain whether cued recall could be useful in differentiating early AD and MCI from depression among elderly individuals. METHOD:The Visual Associa...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170600955X

    authors: Dierckx E,Engelborghs S,De Raedt R,De Deyn PP,Ponjaert-Kristoffersen I

    更新日期:2007-05-01 00:00:00

  • Which adolescents develop persistent substance dependence in adulthood? Using population-representative longitudinal data to inform universal risk assessment.

    abstract:BACKGROUND:To our knowledge, there are no universal screening tools for substance dependence that (1) were developed using a population-based sample, (2) estimate total risk briefly and inexpensively by incorporating a relatively small number of well-established risk factors, and (3) aggregate risk factors using a simp...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291715002482

    authors: Meier MH,Hall W,Caspi A,Belsky DW,Cerdá M,Harrington HL,Houts R,Poulton R,Moffitt TE

    更新日期:2016-03-01 00:00:00

  • The temptation of suicide: striatal gray matter, discounting of delayed rewards, and suicide attempts in late-life depression.

    abstract:BACKGROUND:Converging evidence implicates basal ganglia alterations in impulsivity and suicidal behavior. For example, D2/D3 agonists and subthalamic nucleus stimulation in Parkinson's disease (PD) trigger impulse control disorders and possibly suicidal behavior. Furthermore, suicidal behavior has been associated with ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002133

    authors: Dombrovski AY,Siegle GJ,Szanto K,Clark L,Reynolds CF,Aizenstein H

    更新日期:2012-06-01 00:00:00

  • Bright light, negative air ions and auditory stimuli produce rapid mood changes in a student population: a placebo-controlled study.

    abstract:BACKGROUND:Bright light and high-density negative air ion exposure are efficacious for winter and non-seasonal depression compared with a low-density negative ion placebo. Similarly, auditory stimuli improve mood in clinical populations. This study compared the short-term effects of bright light, an auditory stimulus, ...

    journal_title:Psychological medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1017/S0033291706008002

    authors: Goel N,Etwaroo GR

    更新日期:2006-09-01 00:00:00

  • Continuity of care in mental health: understanding and measuring a complex phenomenon.

    abstract:BACKGROUND:Continuity of care is considered by patients and clinicians an essential feature of good quality care in long-term disorders, yet there is general agreement that it is a complex concept. Most policies emphasize it and encourage systems to promote it. Despite this, there is no accepted definition or measure a...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291708003747

    authors: Burns T,Catty J,White S,Clement S,Ellis G,Jones IR,Lissouba P,McLaren S,Rose D,Wykes T

    更新日期:2009-02-01 00:00:00

  • Marriage, motherhood and psychiatric morbidity in New Zealand.

    abstract::The prevalence of psychiatric disorder, as assessed by both the GHQ-28 and the short PSE, is described for a random community sample of New Zealand women. In contrast to previous studies, married and widowed women and mothers showed lower rates than the never married and childless women. A plausible explanation is pro...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700009909

    authors: Romans-Clarkson SE,Walton VA,Herbison GP,Mullen PE

    更新日期:1988-11-01 00:00:00

  • Attention bias to faces in Asperger Syndrome: a pictorial emotion Stroop study.

    abstract:BACKGROUND:Emotional Stroop tasks have shown attention biases of clinical populations towards stimuli related to their condition. Asperger Syndrome (AS) is a neuropsychiatric condition with social and communication deficits, repetitive behaviours and narrow interests. Social deficits are particularly striking, includin...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291706007203

    authors: Ashwin C,Wheelwright S,Baron-Cohen S

    更新日期:2006-06-01 00:00:00

  • Systematic review of multi-symptom conditions in Gulf War veterans.

    abstract:BACKGROUND:Gulf War veterans have a number of health complaints. We therefore decided to carry out a systematic review to identify and summarize the findings from studies that have assessed multi-symptom conditions in Gulf War veterans and in an unexposed comparison group. METHOD:Studies published between January 1990...

    journal_title:Psychological medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1017/S0033291705006975

    authors: Thomas HV,Stimpson NJ,Weightman AL,Dunstan F,Lewis G

    更新日期:2006-06-01 00:00:00