Abstract:
BACKGROUND:Three cognitive constructs are risk factors for eating disorders: undue influence of weight and shape, concern about weight and shape, and body dissatisfaction (BD). Undue influence, a diagnostic criterion for eating disorders, is postulated to be closely associated with self-esteem whereas BD is postulated to be closely associated with body mass index (BMI). We understand less about the relationships with concern about weight and shape. The aim of the current investigation was examine the degree of overlap across these five phenotypes in terms of latent genetic and environmental risk factors in order to draw some conclusions about the similarities and differences across the three cognitive variables. METHOD:A sample of female Australian twins (n=1056, including 348 complete pairs), mean age 35 years (S.D.=2.11, range 28-40), completed a semi-structured interview about eating pathology and self-report questionnaires. An independent pathways model was used to investigate the overlap of genetic and environmental risk factors for the five phenotypes. RESULTS:In terms of variance that was not shared with other phenotypes, self-esteem emerged as being separate, with 100% of its variance unshared with the other phenotypes, followed by undue influence (51%) and then concern (34%), BD (28%) and BMI (32%). CONCLUSIONS:In terms of shared genetic risk, undue influence and concern were more closely related than BD, whereas BMI and BD were found to share common sources of risk. With respect to environmental risk factors, concern, BMI and BD were more closely related to each other than to undue influence.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Wade TD,Zhu G,Martin NGdoi
10.1017/S0033291710001066subject
Has Abstractpub_date
2011-04-01 00:00:00pages
819-28issue
4eissn
0033-2917issn
1469-8978pii
S0033291710001066journal_volume
41pub_type
杂志文章abstract:BACKGROUND:The aim of the study was to determinate whether schizophrenia patients with a history of cannabis use have a different prognosis, with regards to readmission and hospital duration, compared with those without a history of cannabis use. METHOD:The present investigation was a cohort study of 50,087 Swedish me...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291714000191
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:A long-standing issue in the health anxiety literature is the extent to which health anxiety is a dimensional or a categorical construct. This study explores this question directly using taxometric procedures. METHOD:Seven hundred and eleven working adults completed an index of health anxiety [the Whiteley ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708003322
更新日期:2009-02-01 00:00:00
abstract:BACKGROUND:Attentional difficulties reported in individuals with anorexia nervosa (AN) may be due to preferential processing of disease-salient stimuli at a pre-attentive or at a conscious level or to a general problem in attention. Attentional difficulties may be associated with duration of illness. METHOD:Female par...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708002961
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:The diagnosis of bipolar disorder in pre-pubertal populations remains difficult and often controversial. Consequently, the clinical and neuropsychological characteristics of mania in the child and adolescent years remain poorly defined. This review provides a clinical account of childhood and adolescent bipo...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291706007446
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Rumination is an important cognitive risk factor for onset and relapse of depression. However, no studies have employed a dimensional approach in investigating the neural correlates of rumination and the relationship with depression. METHOD:Non-clinical healthy subjects (n = 306), who completed the classica...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000938
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Adverse psychosocial working environments characterized by job strain (the combination of high demands and low control at work) are associated with an increased risk of depressive symptoms among employees, but evidence on clinically diagnosed depression is scarce. We examined job strain as a risk factor for ...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1017/S003329171600355X
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Patients with anorexia nervosa (AN) run a high risk of becoming chronically ill and of dying. In the acute phase of their illness they present with numerous physical and laboratory abnormalities. However, little is known about the long-term prognostic value of these findings or about the medical morbidity in...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004394
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND:Suicide is a leading cause of death and has been strongly associated with affective disorders. The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort. METHOD:Participants...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291708004078
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is a developmental condition that profoundly affects quality of life. Although mounting evidence now suggests uncontrolled mind-wandering as a core aspect of the attentional problems associated with ADHD, the neural mechanisms underpinning this deficit remains ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003598
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:A wealth of clinical studies have identified objective biomarkers, which separate schizophrenia patients from healthy controls on a group level, but current diagnostic systems solely include clinical symptoms. In this study, we investigate if machine learning algorithms on multimodal data can serve as a fram...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718003781
更新日期:2019-12-01 00:00:00
abstract::Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9...
journal_title:Psychological medicine
pub_type: 杂志文章,meta分析
doi:10.1017/S0033291718003021
更新日期:2019-04-01 00:00:00
abstract::The diversity of research methods applied to psychiatric disorders results in a confusing plethora of causal claims. To help make sense of these claims, the interventionist model (IM) of causality has several attractive features. First, it connects causation with the practical interests of psychiatry, defining causati...
journal_title:Psychological medicine
pub_type: 社论,评审
doi:10.1017/S0033291708004467
更新日期:2009-06-01 00:00:00
abstract::Patients suffering from manic-depressive psychosis, manic type (ICD 296.0), were treated with lithium carbonate and randomly allocated to two groups, one received digoxin and the other matching placebo for 7 days. Severity of mania was rated by psychiatrists on the Manic Rating Scale and Analogue Line on days 0 and 7 ...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1017/s0033291700043282
更新日期:1982-02-01 00:00:00
abstract:BACKGROUND:Parental characteristics and practices predict borderline personality disorder (BPD) symptoms in children. However, it is difficult to disentangle whether these effects are genetically or environmentally mediated. The present study examines the contributions of genetic and environmental influences by compari...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719001260
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Two types of mentalization-based treatment (MBT), day hospital MBT (MBT-DH) and intensive outpatient MBT (MBT-IOP), have been shown to be effective in treating patients with borderline personality disorder (BPD). This study evaluated trajectories of change in a multi-site trial of MBT-DH and MBT-IOP at 36 mo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720002123
更新日期:2020-06-30 00:00:00
abstract:BACKGROUND:Excessive worry is a defining feature of generalized anxiety disorder and is present in a wide range of other psychiatric conditions. Therefore, individualized predictions of worry propensity could be highly relevant in clinical practice, with respect to the assessment of worry symptom severity at the indivi...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718002763
更新日期:2019-09-01 00:00:00
abstract:BACKGROUND:Although alcohol use disorder (AUD) is associated with future risk for psychosocial dysfunction, the degree to which this arises from a direct causal effect of AUD on functioning v. from correlated risk factors (also known as confounders) is less clearly established. METHOD:AUD was assessed from Swedish med...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716003032
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Dissociative reactions in post-traumatic stress disorder (PTSD) have been regarded as strategic responses that limit arousal. Neuroimaging studies suggest distinct prefrontal responses in individuals displaying dissociative and hyperarousal responses to threat in PTSD. Increased prefrontal activity may refle...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291708002742
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND:Depressive syndromes not fulfilling the criteria for specified disorders (subthreshold depression, SD) may be clinically important. We aimed to study SD in old and very old age, in comparison with subjects with no depressive symptoms (NDS) and subjects with major depression (MD). METHODS:A community-based r...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291799002883
更新日期:2001-01-01 00:00:00
abstract::The incidence of cavum septum pellucidum (CSP), which has been widely regarded as a developmental anomaly of little clinical importance in neuropathology, was examined in 113 patients with affective disorders (69 with bipolar disorder and 44 with major depression), 40 schizophrenic patients, and 92 control subjects by...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034838
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The assessment of inter-regional functional connectivity (FC) has allowed for the description of the putative mechanism of action of treatments such as deep brain stimulation (DBS) of the nucleus accumbens in patients with obsessive-compulsive disorder (OCD). Nevertheless, the possible FC alterations of othe...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291717002288
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:In resource-poor countries, there remains an alarming treatment gap for people with schizophrenia, particularly those living in rural areas. Decentralization of mental health services, including community-based outreach programmes, represents one obvious strategy for bringing appropriate care to these commun...
journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291704003551
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Early Intervention in Psychosis Services (EIS) for young people in England experiencing first-episode psychosis (FEP) were commissioned in 2002, based on an expected incidence of 15 cases per 100 000 person-years, as reported by schizophrenia epidemiology in highly urban settings. Unconfirmed reports from EI...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291710002461
更新日期:2011-05-01 00:00:00
abstract::Recent studies have suggested that expanded CAG/CTG repeats contribute to the genetic aetiology of schizophrenia and bipolar disorder. However, the nature of this contribution is uncertain and difficult to predict from other known trinucleotide repeat diseases that display much simpler patterns of inheritance. We have...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700035868
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Women's vulnerability for a first lifetime-onset of major depressive disorder (MDD) during midlife is substantial. It is unclear whether risk factors differ for first lifetime-onset and recurrent MDD. Identifying these risk factors can provide more focused depression screening and earlier intervention. This ...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究
doi:10.1017/S0033291714002773
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Bipolar disorder I (BD-I) is defined by episodes of mania, depression and euthymic states. These episodes are among other symptoms characterized by altered reward processing and negative symptoms (NS), in particular apathy. However, the neural correlates of these deficits are not well understood. METHODS:We...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291719000801
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Depression is associated with alterations of emotional and cognitive processing, and executive control in particular. Previous research has shown that depressed patients are impaired in their ability to shift attention from one emotional category to another, but whether this shifting deficit is more evident ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002418
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:The long-term outcomes of bipolar disorder range from lasting remission to chronic course or frequent recurrences requiring admissions. The distinction between bipolar I and II disorders has limited utility in outcome prediction. It is unclear to what extent the clinical course of bipolar disorder predicts l...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001678
更新日期:2019-05-01 00:00:00
abstract::Changes in the erythrocyte membrane cation carrier following lithium ingestion in normal human subjects were studied; ouabain sensitive potassium influx fell significantly during the lithium treated phase. Lithium was fed to rats and no change in erythrocyte Na-K ATPase was shown. These findings contrast with studies ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700029305
更新日期:1977-05-01 00:00:00
abstract:BACKGROUND:Several questions remain unanswered regarding the magnitude and time course of cognitive improvement in response to antipsychotic treatment. The purpose of this study was to assess changes in cognitive performance in antipsychotic-naive or minimally medicated patients with first-episode schizophrenia during ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291715000860
更新日期:2015-10-01 00:00:00