Abstract:
:Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood. We assessed the quality of studies using the Newcastle-Ottawa Quality Assessment Scales. Independent risk estimates were pooled using random-effects meta-analyses when at least two independent datasets provided data on the same symptom or disorder. Otherwise, we provided narrative summaries. Two studies examined cognitive impairment, one examined problem behavior, three examined attention-deficit/hyperactivity disorder (ADHD) and seven focused on autism spectrum disorders (ASD). We provided narrative summaries of the studies on cognitive impairment. For ADHD, the pooled risk estimate was 1.17; 95% confidence interval (CI) 0.77-1.78, based on a pooled sample size of 5 47 278 offspring. For ASD, the pooled risk estimate was 1.10; 95% CI 1.04-1.17, based on 8 87 470 offspring. Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Lønfeldt NN,Verhulst FC,Strandberg-Larsen K,Plessen KJ,Lebowitz ERdoi
10.1017/S0033291718003021subject
Has Abstractpub_date
2019-04-01 00:00:00pages
881-890issue
6eissn
0033-2917issn
1469-8978pii
S0033291718003021journal_volume
49pub_type
杂志文章,meta分析abstract::Previously employed techniques for the measurement of body image are briefly described, with a short consideration of methodological or procedural limitations associated with each technique. A new procedure is described which employs a simple modification to a standard video camera to produce an image which appears fr...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700003652
更新日期:1984-05-01 00:00:00
abstract::The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic s...
journal_title:Psychological medicine
pub_type: 社论
doi:10.1017/s003329170500437x
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Individuals with depression are often found to perform worse on cognitive tests and to have an increased risk of dementia. The causes and the direction of these associations are however not well understood. We looked at two specific hypotheses, the aetiological risk factor hypothesis and the reverse causalit...
journal_title:Psychological medicine
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doi:10.1017/S0033291720003037
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journal_title:Psychological medicine
pub_type: 临床试验,杂志文章
doi:10.1017/s0033291798006862
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291718001976
更新日期:2019-07-01 00:00:00
abstract::The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to a...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700000611
更新日期:1987-11-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700047486
更新日期:1980-08-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291716001057
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed. METHODS:selective review of the recent literature on molecular genetic and genomic approaches to the ps...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291709991139
更新日期:2010-04-01 00:00:00
abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700024934
更新日期:1987-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291702005809
更新日期:2002-07-01 00:00:00
abstract::Twenty-three acute psychotic patients who were drug free at the time of testing performed a motor task designed to elicit many errors. Normal subjects and many of the psychotic patients were able to correct these errors in the absence of visual feedback. The ability to make such corrections depends on the subject know...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s003329170001240x
更新日期:1989-05-01 00:00:00
abstract::The present study examined sensitivity to noise in subjects with Type A and Type B behaviour patterns as a function of the type of task being performed. Twenty Type A and 20 Type B subjects, selected by means of Bortner's scale (French version), were exposed to steadily increasing noise levels (68-110 dBA) while perfo...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700015245
更新日期:1984-08-01 00:00:00
abstract::Despite the robust body of work on cognitive aspects of bipolar disorder (BD), a clear profile of associated impairments in impulsivity, decision-making and risk-taking from studies that use behavioural measures has yet to be established. A systematic review, across four electronic databases (PsycINFO, MEDLINE/PubMed,...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291720003086
更新日期:2020-10-01 00:00:00
abstract::The CAMCOG, the cognitive section of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX), was administered twice to 53 patients with a clinical diagnosis ranging from no dementia to severe dementia. The stability of the total CAMCOG score was high (0.97). Patients with less than moderate dementia we...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700039003
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Excessive worry is required by DSM-IV, but not ICD-10, for a diagnosis of generalized anxiety disorder (GAD). No large-scale epidemiological study has ever examined the implications of this requirement for estimates of prevalence, severity, or correlates of GAD. METHOD:Data were analyzed from the US Nationa...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291705005908
更新日期:2005-12-01 00:00:00
abstract::In a prospective cohort study of consecutive primary care attenders in south London, the estimated prevalence of non-psychotic psychiatric disorder was 45.6%, using the Revised Clinical Interview Schedule (CIS-R). The estimated 12-month incidence rate was 15.7%. Extremely high stability was found in CIS-R scores over ...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004023
更新日期:1997-01-01 00:00:00
abstract::The term 'pseudohallucination' is currently used to name imaginal experiences whose relationship to one another and to hallucinations 'proper' remains obscure. Clinicians, including specialists in psychopathology, disagree on how pseudohallucination must be defined and on its diagnostic role. Empirical research is unl...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/s0033291700037776
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...
journal_title:Psychological medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S0033291713000949
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Recently released prisoners are at markedly higher risk of suicide than the general population. The aim of this study was to identify key risk factors for suicide by offenders released from prisons in England and Wales. METHOD:All suicides committed by offenders within 12 months of their release from prison...
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pub_type: 杂志文章
doi:10.1017/S0033291709991048
更新日期:2010-05-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291715000537
更新日期:2015-01-01 00:00:00
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journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291796004412
更新日期:1997-03-01 00:00:00
abstract::One week after Sir William Gull read his seminal report on anorexia nervosa to the Clinical Society of London, a brief account was published (Anonymous, 1873). In Paris, Charles Lasègue, editor of Archives Générales de Médecine read the report and printed an immediate editorial riposte, parts of which will be quoted i...
journal_title:Psychological medicine
pub_type: 传,历史文章,杂志文章
doi:10.1017/s0033291700030245
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Despite methodological differences between studies, it has been suggested that psychopathy may be associated with a ventromedial prefrontal cortex (VMPFC) deficit and antisocial personality disorder (ASPD), as classified in the DSM-IV, with a broader range of deficits in dorsolateral prefrontal cortex (DLPFC...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S0033291711002686
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. Howeve...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S0033291710001042
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Despite markedly different clinical presentations, few studies have reported differences in neuropsychological functioning between mania and depression. Recent work has suggested that differences may emerge on cognitive tasks requiring affective processing, such as decision-making. The present study sought t...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291701003804
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Overall findings of our first direct interview family study of obsessive-compulsive disorder (OCD) indicated that OCD is familial. In this replication study, we carefully examined the role of informant data in ascertaining OCD in relatives. METHOD:We interviewed 112 relatives of 57 OCD patients and 115 rela...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/S003329170500543X
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:Slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the frontal cortex has been suggested as a safer and better tolerable alternative to fast-frequency rTMS in the treatment of major depressive disorder (MDD). The aim of the present study was to examine the efficacy of slow-frequency rTMS t...
journal_title:Psychological medicine
pub_type: 杂志文章,评审
doi:10.1017/S003329171000005X
更新日期:2010-11-01 00:00:00
abstract::One hundred and sixteen working-class housewives, part-time and full-time employees were compared on a range of well-being measures in three different lifestages. A group of factory employees was contrasted with a 'mixed occupation' group for a comparison of type of employment. The general contention that the associat...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700034978
更新日期:1995-07-01 00:00:00
abstract::Although most chronically impaired psychiatric patients now reside in community-based residential homes, a substantial number show little progress in their social rehabilitation. To establish the rehabilitative needs of this population, the current study sought to examine the social behaviour of residents of a large r...
journal_title:Psychological medicine
pub_type: 杂志文章
doi:10.1017/s0033291700050960
更新日期:1983-05-01 00:00:00