Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis.

Abstract:

:Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood. We assessed the quality of studies using the Newcastle-Ottawa Quality Assessment Scales. Independent risk estimates were pooled using random-effects meta-analyses when at least two independent datasets provided data on the same symptom or disorder. Otherwise, we provided narrative summaries. Two studies examined cognitive impairment, one examined problem behavior, three examined attention-deficit/hyperactivity disorder (ADHD) and seven focused on autism spectrum disorders (ASD). We provided narrative summaries of the studies on cognitive impairment. For ADHD, the pooled risk estimate was 1.17; 95% confidence interval (CI) 0.77-1.78, based on a pooled sample size of 5 47 278 offspring. For ASD, the pooled risk estimate was 1.10; 95% CI 1.04-1.17, based on 8 87 470 offspring. Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated.

journal_name

Psychol Med

journal_title

Psychological medicine

authors

Lønfeldt NN,Verhulst FC,Strandberg-Larsen K,Plessen KJ,Lebowitz ER

doi

10.1017/S0033291718003021

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

881-890

issue

6

eissn

0033-2917

issn

1469-8978

pii

S0033291718003021

journal_volume

49

pub_type

杂志文章,meta分析
  • A modified video camera for measuring body image distortion: technical description and reliability.

    abstract::Previously employed techniques for the measurement of body image are briefly described, with a short consideration of methodological or procedural limitations associated with each technique. A new procedure is described which employs a simple modification to a standard video camera to produce an image which appears fr...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700003652

    authors: Freeman RJ,Thomas CD,Solyom L,Hunter MA

    更新日期:1984-05-01 00:00:00

  • Chronotherapeutics (light and wake therapy) in affective disorders.

    abstract::The Committee on Chronotherapeutics, delegated by the International Society for Affective Disorders (ISAD), makes the following recommendations after reviewing the evidence as of November 2004. (1) Wake therapy is the most rapid antidepressant available today: approximately 60% of patients, independent of diagnostic s...

    journal_title:Psychological medicine

    pub_type: 社论

    doi:10.1017/s003329170500437x

    authors: Wirz-Justice A,Benedetti F,Berger M,Lam RW,Martiny K,Terman M,Wu JC

    更新日期:2005-07-01 00:00:00

  • Depression and memory function - evidence from cross-lagged panel models with unit fixed effects in ELSA and HRS.

    abstract:BACKGROUND:Individuals with depression are often found to perform worse on cognitive tests and to have an increased risk of dementia. The causes and the direction of these associations are however not well understood. We looked at two specific hypotheses, the aetiological risk factor hypothesis and the reverse causalit...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720003037

    authors: Jindra C,Li C,Tsang RSM,Bauermeister S,Gallacher J

    更新日期:2020-09-11 00:00:00

  • Cognitive impairment in the euthymic phase of affective disorder.

    abstract:BACKGROUND:A review of studies of cognition in the euthymic phase of unipolar and bipolar affective disorder reveals diverging results. METHODS:The study was designed as a controlled cohort study, with the Danish psychiatric case register of admissions used to identify patients and the Danish civil register to identif...

    journal_title:Psychological medicine

    pub_type: 临床试验,杂志文章

    doi:10.1017/s0033291798006862

    authors: Kessing LV

    更新日期:1998-09-01 00:00:00

  • Beyond not bad or just okay: social predictors of young adults' wellbeing and functioning (a TRAILS study).

    abstract:BACKGROUND:Various childhood social experiences have been reported to predict adult outcomes. However, it is unclear how different social contexts may influence each other's effects in the long run. This study examined the joint contribution of adolescent family and peer experiences to young adult wellbeing and functio...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291718001976

    authors: Richards JS,Hartman CA,Jeronimus BF,Ormel J,Reijneveld SA,Veenstra R,Verhulst FC,Vollebergh WAM,Oldehinkel AJ

    更新日期:2019-07-01 00:00:00

  • Mutation and psychosis: a suggested explanation of seasonality of birth.

    abstract::The persistence of psychosis at a high and relatively constant prevalence in the various populations of the world is rendered difficult to explain by the absence of identified environmental precipitants and by reduced fertility of affected individuals. The problem is not confined to schizophrenia but applies also to a...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700000611

    authors: Crow TJ

    更新日期:1987-11-01 00:00:00

  • On establishing the validity of 'objective' data: can we rely on cross-interview agreement?

    abstract::It has been proposed that a high level of agreement between informants' reports about events and happenings ('objective' data) is a sound basis for establishing (a) the validity of the measure which is based on the reports, and (b) the nature of objective reality. In this paper it is argued that such agreement may not...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700047486

    authors: Platt S

    更新日期:1980-08-01 00:00:00

  • Cortical salience network activation precedes the development of delusion severity.

    abstract:BACKGROUND:Delusion is the most characteristic symptom of psychosis. While researchers suggested an association between changes of the cortical salience network (CSN) and delusion, whether these CSN findings are a cause or a consequence of delusion remains unknown. METHOD:To assess the effect of CSN functioning to for...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291716001057

    authors: Raij TT,Mäntylä T,Mantere O,Kieseppä T,Suvisaari J

    更新日期:2016-10-01 00:00:00

  • What have the genomics ever done for the psychoses?

    abstract:BACKGROUND:Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed. METHODS:selective review of the recent literature on molecular genetic and genomic approaches to the ps...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291709991139

    authors: Gill M,Donohoe G,Corvin A

    更新日期:2010-04-01 00:00:00

  • Lymphocyte numbers in endogenous depression.

    abstract::The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in bot...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700024934

    authors: Murphy D,Gardner R,Greden JF,Carroll BJ

    更新日期:1987-05-01 00:00:00

  • The Aberdeen Trauma Screening Index: an instrument to predict post-accident psychopathology.

    abstract:BACKGROUND:A key challenge in trauma care is the prevention of psychopathology. However, no definitive method of identifying individuals at risk of developing psychopathology exists. The Aberdeen Trauma Screening Index (ATSI) is a brief screening tool developed for use in a clinical setting by non-mental health profess...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291702005809

    authors: Klein S,Alexander DA,Hutchinson JD,Simpson JA,Simpson JM,Bell JS

    更新日期:2002-07-01 00:00:00

  • Experiences of alien control in schizophrenia reflect a disorder in the central monitoring of action.

    abstract::Twenty-three acute psychotic patients who were drug free at the time of testing performed a motor task designed to elicit many errors. Normal subjects and many of the psychotic patients were able to correct these errors in the absence of visual feedback. The ability to make such corrections depends on the subject know...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s003329170001240x

    authors: Frith CD,Done DJ

    更新日期:1989-05-01 00:00:00

  • Type A and type B behaviour patterns, task type and sensitivity to noise.

    abstract::The present study examined sensitivity to noise in subjects with Type A and Type B behaviour patterns as a function of the type of task being performed. Twenty Type A and 20 Type B subjects, selected by means of Bortner's scale (French version), were exposed to steadily increasing noise levels (68-110 dBA) while perfo...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700015245

    authors: Moch A

    更新日期:1984-08-01 00:00:00

  • Impulsivity, decision-making and risk-taking behaviour in bipolar disorder: a systematic review and meta-analysis.

    abstract::Despite the robust body of work on cognitive aspects of bipolar disorder (BD), a clear profile of associated impairments in impulsivity, decision-making and risk-taking from studies that use behavioural measures has yet to be established. A systematic review, across four electronic databases (PsycINFO, MEDLINE/PubMed,...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291720003086

    authors: Ramírez-Martín A,Ramos-Martín J,Mayoral-Cleries F,Moreno-Küstner B,Guzman-Parra J

    更新日期:2020-10-01 00:00:00

  • Some psychometric properties of the CAMCOG.

    abstract::The CAMCOG, the cognitive section of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX), was administered twice to 53 patients with a clinical diagnosis ranging from no dementia to severe dementia. The stability of the total CAMCOG score was high (0.97). Patients with less than moderate dementia we...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700039003

    authors: Lindeboom J,Ter Horst R,Hooyer C,Dinkgreve M,Jonker C

    更新日期:1993-02-01 00:00:00

  • Should excessive worry be required for a diagnosis of generalized anxiety disorder? Results from the US National Comorbidity Survey Replication.

    abstract:BACKGROUND:Excessive worry is required by DSM-IV, but not ICD-10, for a diagnosis of generalized anxiety disorder (GAD). No large-scale epidemiological study has ever examined the implications of this requirement for estimates of prevalence, severity, or correlates of GAD. METHOD:Data were analyzed from the US Nationa...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291705005908

    authors: Ruscio AM,Lane M,Roy-Byrne P,Stang PE,Stein DJ,Wittchen HU,Kessler RC

    更新日期:2005-12-01 00:00:00

  • Do socio-economic risk factors predict the incidence and maintenance of psychiatric disorder in primary care?

    abstract::In a prospective cohort study of consecutive primary care attenders in south London, the estimated prevalence of non-psychotic psychiatric disorder was 45.6%, using the Revised Clinical Interview Schedule (CIS-R). The estimated 12-month incidence rate was 15.7%. Extremely high stability was found in CIS-R scores over ...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291796004023

    authors: Weich S,Churchill R,Lewis G,Mann A

    更新日期:1997-01-01 00:00:00

  • Pseudohallucinations: a conceptual history.

    abstract::The term 'pseudohallucination' is currently used to name imaginal experiences whose relationship to one another and to hallucinations 'proper' remains obscure. Clinicians, including specialists in psychopathology, disagree on how pseudohallucination must be defined and on its diagnostic role. Empirical research is unl...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/s0033291700037776

    authors: Berrios GE,Dening TR

    更新日期:1996-07-01 00:00:00

  • Treating severe and enduring anorexia nervosa: a randomized controlled trial.

    abstract:BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...

    journal_title:Psychological medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1017/S0033291713000949

    authors: Touyz S,Le Grange D,Lacey H,Hay P,Smith R,Maguire S,Bamford B,Pike KM,Crosby RD

    更新日期:2013-12-01 00:00:00

  • Suicide in recently released prisoners: a case-control study.

    abstract:BACKGROUND:Recently released prisoners are at markedly higher risk of suicide than the general population. The aim of this study was to identify key risk factors for suicide by offenders released from prisons in England and Wales. METHOD:All suicides committed by offenders within 12 months of their release from prison...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291709991048

    authors: Pratt D,Appleby L,Piper M,Webb R,Shaw J

    更新日期:2010-05-01 00:00:00

  • What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review.

    abstract::The powerful genome-wide association studies (GWAS) revealed common mutations that increase susceptibility for schizophrenia (SZ) and bipolar disorder (BD), but the vast majority were not known to be functional or associated with these illnesses. To help fill this gap, their impact on human brain structure and functio...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291715000537

    authors: Gurung R,Prata DP

    更新日期:2015-01-01 00:00:00

  • The effects of unemployment on psychiatric illness during young adulthood.

    abstract:BACKGROUND:The aims of this study were to examine the associations between exposure to unemployment following school leaving and rates of psychiatric disorder using data gathered on a birth cohort of New Zealand young people studied up to the age of 18. METHODS:At age 18 cohort members were assessed on: (a) duration o...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291796004412

    authors: Fergusson DM,Horwood LJ,Lynskey MT

    更新日期:1997-03-01 00:00:00

  • Lasègue's editorial riposte to Gull's contributions on anorexia nervosa.

    abstract::One week after Sir William Gull read his seminal report on anorexia nervosa to the Clinical Society of London, a brief account was published (Anonymous, 1873). In Paris, Charles Lasègue, editor of Archives Générales de Médecine read the report and printed an immediate editorial riposte, parts of which will be quoted i...

    journal_title:Psychological medicine

    pub_type: 传,历史文章,杂志文章

    doi:10.1017/s0033291700030245

    authors: Silverman JA

    更新日期:1992-05-01 00:00:00

  • The neuropsychology of prefrontal function in antisocial personality disordered offenders with varying degrees of psychopathy.

    abstract:BACKGROUND:Despite methodological differences between studies, it has been suggested that psychopathy may be associated with a ventromedial prefrontal cortex (VMPFC) deficit and antisocial personality disorder (ASPD), as classified in the DSM-IV, with a broader range of deficits in dorsolateral prefrontal cortex (DLPFC...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S0033291711002686

    authors: Dolan M

    更新日期:2012-08-01 00:00:00

  • Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder.

    abstract:BACKGROUND:Neurocognitive dysfunction in schizophrenia (SZ), bipolar (BD) and related disorders represents a core feature of these illnesses, possibly a marker of underlying pathophysiology. Substantial overlap in domains of neuropsychological deficits has been reported among these disorders after illness onset. Howeve...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S0033291710001042

    authors: Lewandowski KE,Cohen BM,Ongur D

    更新日期:2011-02-01 00:00:00

  • Decision-making cognition in mania and depression.

    abstract:BACKGROUND:Despite markedly different clinical presentations, few studies have reported differences in neuropsychological functioning between mania and depression. Recent work has suggested that differences may emerge on cognitive tasks requiring affective processing, such as decision-making. The present study sought t...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291701003804

    authors: Murphy FC,Rubinsztein JS,Michael A,Rogers RD,Robbins TW,Paykel ES,Sahakian BJ

    更新日期:2001-05-01 00:00:00

  • A direct interview family study of obsessive-compulsive disorder. II. Contribution of proband informant information.

    abstract:BACKGROUND:Overall findings of our first direct interview family study of obsessive-compulsive disorder (OCD) indicated that OCD is familial. In this replication study, we carefully examined the role of informant data in ascertaining OCD in relatives. METHOD:We interviewed 112 relatives of 57 OCD patients and 115 rela...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/S003329170500543X

    authors: Lipsitz JD,Mannuzza S,Chapman TF,Foa EB,Franklin ME,Goodwin RD,Fyer AJ

    更新日期:2005-11-01 00:00:00

  • Quantitative review of the efficacy of slow-frequency magnetic brain stimulation in major depressive disorder.

    abstract:BACKGROUND:Slow-frequency repetitive transcranial magnetic stimulation (rTMS) to the frontal cortex has been suggested as a safer and better tolerable alternative to fast-frequency rTMS in the treatment of major depressive disorder (MDD). The aim of the present study was to examine the efficacy of slow-frequency rTMS t...

    journal_title:Psychological medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S003329171000005X

    authors: Schutter DJ

    更新日期:2010-11-01 00:00:00

  • The family life cycle: a forgotten variable in the study of women's employment and well-being.

    abstract::One hundred and sixteen working-class housewives, part-time and full-time employees were compared on a range of well-being measures in three different lifestages. A group of factory employees was contrasted with a 'mixed occupation' group for a comparison of type of employment. The general contention that the associat...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700034978

    authors: Haw CE

    更新日期:1995-07-01 00:00:00

  • Residential care and social behaviour: a study of rehabilitation needs.

    abstract::Although most chronically impaired psychiatric patients now reside in community-based residential homes, a substantial number show little progress in their social rehabilitation. To establish the rehabilitative needs of this population, the current study sought to examine the social behaviour of residents of a large r...

    journal_title:Psychological medicine

    pub_type: 杂志文章

    doi:10.1017/s0033291700050960

    authors: Falloon IR,Marshall GN

    更新日期:1983-05-01 00:00:00