Adverse life event reporting and worst illness episodes in unipolar and bipolar affective disorders: measuring environmental risk for genetic research.

abstract：:Messenger RNA (mRNA) is the key intermediate in the gene expression pathway. The amount of mRNA in Alzheimer's disease (AD) brains has been determined using in situ hybridization histochemistry (ISHH) to detect the poly(A) tails of polyadenylated mRNA (poly(A) + mRNA). On a regional basis, AD cases had significantly l...

journal_title：Psychological medicine

authors： Harrison PJ,Barton AJ,Najlerahim A,McDonald B,Pearson RC

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:To assess the prevalence and clinical impact of co-morbid social anxiety disorder (SAD) and alcohol use disorders (AUD, i.e. alcohol abuse and alcohol dependence) in a nationally representative sample of adults in the United States. METHOD:Data came from a large representative sample of the US population. F...

journal_title：Psychological medicine

authors： Schneier FR,Foose TE,Hasin DS,Heimberg RG,Liu SM,Grant BF,Blanco C

更新日期：2010-06-01 00:00:00

abstract：:Fifty-six bulimia nervosa patients were treated by means of a behavioural approach and followed for at least one year after completion or dropping out of treatment. Outcome was encouraging in about half of the patients and several psychiatric indicators, such as duration of illness and response to treatment, were iden...

journal_title：Psychological medicine

authors： Hsu LK,Holder D

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Previous research suggests that genetic influences on disordered eating may be greater in pubertal than pre-pubertal girls. Although these findings are consistent with pubertal activation of genetic influences on disordered eating, earlier studies were unable to directly test this hypothesis. The purpose of ...

journal_title：Psychological medicine

authors： Klump KL,Perkins PS,Alexandra Burt S,McGue M,Iacono WG

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Prior research on work-related factors in the aetiology of psychiatric disorders has been concentrated on job control, job demands and social support. To broaden the view to managerial procedures, we examined whether the extent to which employees are treated with equity in the workplace predicts their mental...

journal_title：Psychological medicine

authors： Kivimäki M,Elovainio M,Vahtera J,Virtanen M,Stansfeld SA

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Both past depressive episodes and the personality trait of depressive rumination are strong risk factors for future depression. Depression is associated with abnormal emotional processing, which may be a neurobiological marker for vulnerability to depression. A consistent picture has yet to emerge as to how ...

journal_title：Psychological medicine

authors： Thomas EJ,Elliott R,McKie S,Arnone D,Downey D,Juhasz G,Deakin JF,Anderson IM

更新日期：2011-09-01 00:00:00

abstract：:In a 5-week study of 22 depressed patients treated with nortriptyline, significant changes in plasma levels, both elevated and reduced, were deliberately produced in the third and fourth weeks of each patient's treatment. Correlation of plasma nortriptyline levels and changes in the severity of depression, as measured...

journal_title：Psychological medicine

authors： Burrows GD,Maguire KP,Scoggins BA,Stevenson J,Davies B

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:The diagnosis of certain psychiatric syndromes (e.g. panic attacks, post-traumatic stress disorder) is crucially dependent on the psychosocial context in which they arise. For other syndromes (e.g. schizophrenia), the context is generally irrelevant. Should the diagnosis of major depression (MD) be made depe...

journal_title：Psychological medicine

authors： Kendler KS,Myers J,Halberstadt LJ

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:The importance of genetic factors in the aetiology of manic-depressive illness (MDI) has been repeatedly confirmed and indicators of vulnerability to the illness in families with affective disorders are needed. Abnormal event-related potentials (ERP) may be markers of genetic vulnerability to mental illness....

journal_title：Psychological medicine

authors： Pierson A,Jouvent R,Quintin P,Perez-Diaz F,Leboyer M

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) has been called one of the signature injuries of the Iraq War. In this review prevalence estimates of PTSD are summarized and discrepancies are discussed in relation to methodological differences between studies. METHOD:We searched for population-based studies with a mi...

journal_title：Psychological medicine

authors： Sundin J,Fear NT,Iversen A,Rona RJ,Wessely S

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The experience of childhood trauma is linked to more severe symptoms and poorer functioning in severe mental disorders; however, the mechanisms behind this are poorly understood. We investigate the relationship between childhood trauma and sleep disturbances in severe mental disorders including the role of s...

journal_title：Psychological medicine

authors： Laskemoen JF,Aas M,Vaskinn A,Berg AO,Lunding SH,Barrett EA,Melle I,Simonsen C

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Previous imaging studies have revealed that acute major depression is characterized by altered neural responses to negative emotional stimuli. Typically, responses in limbic regions such as the amygdala are increased while activity in cortical regulatory regions such as the dorsolateral prefrontal cortex (DL...

journal_title：Psychological medicine

authors： Norbury R,Selvaraj S,Taylor MJ,Harmer C,Cowen PJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The effectiveness of therapeutic interventions in psychosis is increasingly reported in terms of reductions in different symptom dimensions. It remains unclear, however, to what degree such symptomatic changes are accompanied by improvement in other measures such as service use, quality of life, and needs fo...

journal_title：Psychological medicine

authors： van Os J,Gilvarry C,Bale R,van Horn E,Tattan T,White I,Murray R

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Prosocial emotions related to self-blame are important in guiding human altruistic decisions. These emotions are elevated in major depressive disorder (MDD), such that MDD has been associated with guilt-driven pathological hyper-altruism. However, the impact of such emotional impairments in MDD on different ...

journal_title：Psychological medicine

authors： Pulcu E,Thomas EJ,Trotter PD,McFarquhar M,Juhasz G,Sahakian BJ,Deakin JF,Anderson IM,Zahn R,Elliott R

更新日期：2015-04-01 00:00:00

abstract：BACKGROUNDS:Cigarette smoking is strongly associated with major depressive disorder (MDD). However, any genetic etiology of such comorbidity and causal relations is poorly understood, especially at the genome-wide level. METHODS:In the present in silico research, we analyzed summary data from the genome-wide associati...

journal_title：Psychological medicine

authors： Yao Y,Xu Y,Cai Z,Liu Q,Ma Y,Li AN,Payne TJ,Li MD

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Although impaired recognition of affective facial expressions has been conclusively linked to antisocial behavior, little is known about the modifiability of this deficit. This study investigated whether and under which circumstances the proposed perceptual insensitivity can be addressed with a brief implici...

journal_title：Psychological medicine

authors： Schönenberg M,Christian S,Gaußer AK,Mayer SV,Hautzinger M,Jusyte A

更新日期：2014-04-01 00:00:00

abstract：:Cognitive dysfunction in depression is associated with poorer clinical outcomes and impaired psychosocial functioning. However, most treatments for depression do not specifically target cognition. Neurocognitive deficits such as memory and concentration problems tend to persist after mood symptoms recover. Improving c...

journal_title：Psychological medicine

authors： Kaser M,Zaman R,Sahakian BJ

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Cognitive models of obsessive-compulsive disorder (OCD) posit dysfunctional appraisal of disorder-relevant stimuli in patients, suggesting disturbances in the processes relying on amygdala-prefrontal connectivity. Recent neuroanatomical models add to the traditional view of dysfunction in corticostriatal cir...

journal_title：Psychological medicine

authors： Paul S,Beucke JC,Kaufmann C,Mersov A,Heinzel S,Kathmann N,Simon D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Executive functions have been proposed as endophenotypes for attention deficit hyperactivity disorder (ADHD); however, data regarding visual memory are lacking. We therefore assessed visual memory in adolescents with ADHD and their unaffected siblings compared with controls. METHOD:The participants included...

journal_title：Psychological medicine

authors： Shang CY,Gau SS

更新日期：2011-12-01 00:00:00

abstract：:A number of computerized tests were used to study visual attention, memory and learning in elderly depressed patients. Impairment was found in approximately 70% of depressed patients and was seen particularly in memory and in measures of latency. Depressed patients showed equivalent impairment in short-term memory but...

journal_title：Psychological medicine

authors： Abas MA,Sahakian BJ,Levy R

更新日期：1990-08-01 00:00:00

abstract：:The Eating Attitudes Test (EAT) and General Health Questionnaire (GHQ) have been validated in an unselected population of 15-year-old South London schoolgirls. Scores on the questionnaires were compared with the results of standard interview. The EAT was found to be an efficient screening instrument for abnormal eatin...

journal_title：Psychological medicine

authors： Mann AH,Wakeling A,Wood K,Monck E,Dobbs R,Szmukler G

更新日期：1983-08-01 00:00:00

abstract：BACKGROUND:Cognitive models postulate that negative-self-schemas (NSS) cause and maintain positive symptoms and that negative affect mediates this link. However, only few studies have tested the temporal mediation claim systematically using an appropriate design. METHODS:A longitudinal cohort design in an online commu...

journal_title：Psychological medicine

authors： Jaya ES,Ascone L,Lincoln TM

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Non-suicidal self-injury (NSSI) prospectively predicts suicidal thoughts and behaviors in civilian populations. Despite high rates of suicide among US military members, little is known about the prevalence and course of NSSI, or how NSSI relates to suicidal thoughts and behaviors, in military personnel. MET...

journal_title：Psychological medicine

authors： Turner BJ,Kleiman EM,Nock MK

更新日期：2019-07-01 00:00:00

abstract：:The numbers of long-stay patients in Danish psychiatric hospitals were studied, based on information from the Danish cumulative psychiatric register and from the census studies of patients in Danish psychiatric hospitals, performed at 5-year intervals since 1957. In 1977, 2079 (20%) of the in-patient population which ...

journal_title：Psychological medicine

authors： Weeke A,Kastrup M,Dupont A

更新日期：1979-08-01 00:00:00

abstract：:Serum creatine phosphokinase (CPK) levels were compared with assaultive behaviour by 46 psychiatric patients. Significant relationships were found between CPK level and violent behaviour prior to admission and CPK level and seclusion as a danger to others while in hospital. No relationship was found between CPK level ...

journal_title：Psychological medicine

authors： Isaacs JS,Yesavage JA

更新日期：1984-02-01 00:00:00

abstract：:Previous studies have reported an increase in depression among recent birth cohorts. Concurrent with the increase in rates of depression, there have been increases in rates of drug and alcohol abuse and dependence. This study sought to determine if the recent increase in rates of depression could be attributed to co-m...

journal_title：Psychological medicine

authors： Klerman GL,Leon AC,Wickramaratne P,Warshaw MG,Mueller TI,Weissman MM,Akiskal H

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:A previous study of women 9 months after discharge from in-patient treatment for depression found that low self-esteem as measured by a self-report questionnaire at admission was associated with a worse prognosis. This study investigates the womens' outcome more than 4 years after discharge and the continued...

journal_title：Psychological medicine

authors： Sherrington JM,Hawton K,Fagg J,Andrew B,Smith D

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Several studies have reported smaller hippocampal volume (HcV) in depression patients; however, the temporality of the association remains unknown. One proposed hypothesis is that depression may cause HcV loss. This study evaluates whether previous depression and recent depressive symptoms are associated wit...

journal_title：Psychological medicine

authors： Elbejjani M,Fuhrer R,Abrahamowicz M,Mazoyer B,Crivello F,Tzourio C,Dufouil C

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Previous research has yielded conflicting evidence regarding the long-term cognitive outcome of depression. Some studies have found evidence for a higher incidence of subsequent cognitive impairment or dementia, while others have refuted this. METHOD:Depression, neuropsychological performance, functional ab...

journal_title：Psychological medicine

authors： Brodaty H,Luscombe G,Anstey KJ,Cramsie J,Andrews G,Peisah C

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:The diagnosis of bipolar disorder in pre-pubertal populations remains difficult and often controversial. Consequently, the clinical and neuropsychological characteristics of mania in the child and adolescent years remain poorly defined. This review provides a clinical account of childhood and adolescent bipo...

journal_title：Psychological medicine

authors： Kyte ZA,Carlson GA,Goodyer IM

更新日期：2006-09-01 00:00:00