Abstract:
BACKGROUND:Previous imaging studies have revealed that acute major depression is characterized by altered neural responses to negative emotional stimuli. Typically, responses in limbic regions such as the amygdala are increased while activity in cortical regulatory regions such as the dorsolateral prefrontal cortex (DLPFC) is diminished. Whether these changes persist in unmedicated recovered patients is unclear. METHOD:We used functional magnetic resonance imaging to examine neural responses to emotional faces in a facial expression-matching task in 16 unmedicated recovered depressed patients and 21 healthy controls. RESULTS:Compared with controls, recovered depressed patients had increased responses bilaterally to fearful faces in the DLPFC and right caudate. Responses in the amygdala did not distinguish the groups. CONCLUSIONS:Our findings indicate that clinical recovery from depression is associated with increased activity in the DLPFC to negative emotional stimuli. We suggest that this increase may reflect a compensatory cortical control mechanism with the effect of limiting emotional dysregulation in limbic regions such as the amygdala.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Norbury R,Selvaraj S,Taylor MJ,Harmer C,Cowen PJdoi
10.1017/S0033291709990596subject
Has Abstractpub_date
2010-03-01 00:00:00pages
425-32issue
3eissn
0033-2917issn
1469-8978pii
S0033291709990596journal_volume
40pub_type
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