Abstract：
:The neurotransmitter theories of the pathogenesis and treatment of mood disorders presented so far focused mainly on serotonergic and catecholaminergic (noradrenergic and dopaminergic) transmission. In recent decades the attention has been also directed towards a role in the pathogenesis of mood disorders of stress axis dysregulation and of neuroplasticity disturbances, which involve the glutamatergic system. In this paper, a role of glutamatergic neurotransmission in the pathogenesis and treatment of unipolar and bipolar affective illness is presented. In the first part, a role of glutamatergic neurotransmission in the central nervous system is presented, with special focus on glutamatergic receptors. The results of molecular-genetic studies pointing to an association between glutamatergic system genes and a predisposition to unipolar and bipolar affective illness are discussed. In the next part, a summary of neurobiological, including neuroimaging findings as to changes in glutamatergic system in mood disorders is done. Following this, a role of glutamatergic system in the mechanism of action of antidepressant and mood-stabilizing drugs as well as therapeutic activity of drugs modifying glutamatergic system is reviewed. Glutamatergic conception of mood disorders allows for a new look on the pathogenesis and treatment of unipolar and bipolar affective illness.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Permoda-Osip A,Rybakowski Jsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
875-88issue
6eissn
0033-2674issn
2391-5854journal_volume
45pub_type
杂志文章,评审abstract：:Amisulpride is an antipsychotic available in Europe since 1990s, in Poland since 2000. Subsequent years brought to Polish market more second-generation compounds such as ziprasidone and aripiprazole. In 2018, the Agency for Health Technology Assessment and Tariff System issued positive recommendation for lurasidone in...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/OnlineFirst/109129
更新日期：2020-10-31 00:00:00
abstract：:The paper presents a critical review regarding the pathogenesis of schizophrenia. The neurodevelopmental theory which is now mostly recognized, needs some explanations, some elements of neurodegenerative theory are revisited. The developmental factors are confirmed as important in the pathogenesis of schizophrenia, bu...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-03-01 00:00:00
abstract：:Monitored treatment of a depressed phase of unipolar affective disorder was conducted in 11 female patients receiving imipramine and in 12 females taking amitriptyline. Patients were randomly assigned to one of the drug and in 6 patients the drugs were switched because of the lack of response to the first used compoun...
journal_title：Psychiatria polska
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-05-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to investigate the general knowledge and attitudes towards ECT among Polish students, including students of medical faculties. Furthermore, the influence of pop-culture on society's opinion about ECT was investigated. METHODS:For this purpose, 1,370 students have been examined with ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/109157
更新日期：2020-06-30 00:00:00
abstract：:A polish translation and the description of the clinical use of the novel screening tool in Alzheimer's disease, a "7 Minute Screen", is presented. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Psychopathological picture of depression and the conduct of some hormone tests vs the therapeutic response to thymoleptics were examined. On the grounds of some diagnostic criteria, 84 patients with affective psychosis were divided into three diagnostic groups: unipolar (DJ, n = 54) and bipolar (DD, n = 20) endogenous...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:A group of 50 patients aged from 12 to 20 with anorexia nervosa was examined: 40 persons with a diagnosis of restricting type and 10 with binge-eating type according to DSM IV. The level of intelligence quotient (IQ) was estimated by using Wechsler Test, selfacceptation by SQ and aspiration by TAT and test of unfinish...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：AIM:The study was aimed at finding relationships between self-concept, alcohol expectancies and drinking in the group of high school students. It was expected that a higher level of alcohol consumption was related to lower self-concept and positive expectancies concerning alcohol use. METHOD:The group of 229 Polish hi...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
abstract：AIM:The paper aims to present the programme, the outcomes and the conclusions of a psychoeducational training series for families with schizophrenia carried out by the Babiński Specialist Hospital in Kraków, Poland. The paper sets out to describe an explorative project based on qualitative study methods. The programme ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/38934
更新日期：2015-01-01 00:00:00
abstract：:In this article we present some of the more important findings from research aimed at the validation and normalisation of the Family Assessment Questionnaire (Dyadic Questionnaire, Family Questionnaire, Self-Estimation Questionnaire), which is the Polish adaptation of Manfred Cierpka's and Gabriele Frevert's "Familien...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:To evaluate harmful interactions between antidepressants and medications used in treatment of cardiovascular disorders. METHODS:The analysis of 66 cases of adverse reactions with a clinical picture indicating, to a degree that is probable or certain, that they were the result of the combination of antidepre...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/96286
更新日期：2019-10-30 00:00:00
abstract：:This review provides an overview of the concepts, methods and current status of the development of the Eleventh Revision of the Mental and Behavioural Disorders chapter of the International Classification of Diseases and Related Health Problems (ICD-11) by the World Health Organization (WHO). Given the global use of t...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/69660
更新日期：2017-04-30 00:00:00
abstract：AIM:This study investigated the relation between problem-solving strategies in the marital conflict and marital satisfaction. METHOD:Four problem-solving strategies (Dialogue, Loyalty, Escalation of conflict and Withdrawal) were measured by the Problem-Solving Strategies Inventory, in two versions: self-report and rep...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-03-01 00:00:00
abstract：:Presented study concerned epidemiology and psychological factors of suicide behavior aiming at establishing preventive measures and criteria for crisis intervention. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1995-11-01 00:00:00
abstract：:We introduce a case of an 18 years old man suspected of murder attempt of his colleague. We made a diagnosis of immature personality with schizoid features; we also want to remind Edward Brzezicki's thoughts on paragnomen. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:The cloze procedure was used to examine: predictability in speech samples from schizophrenics and their mothers as well as their ability to gain from the redundancy of language. Schizophrenic patients were found to be less predictable than normals, both schizophrenics and their mothers were less able to make use of th...
journal_title：Psychiatria polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-05-01 00:00:00
abstract：OBJECTIVES:The objective of the study was to show the correlation between the feelings of stigmatization and depressive symptoms in psoriasis patients. The study has considered severity of feelings of stigmatization and depressive symptoms, as well as factors such as gender and skin lesions visibility. METHODS:The stu...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/68848
更新日期：2017-12-30 00:00:00
abstract：:Up to 30% of medical students suffer from depression. They have better access to healthcare, but still receive appropriate treatment less frequently than people with depression in the general population. Most of them do not seek medical help as depression is perceived as a stigmatizing disorder, which leads to self-st...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/OnlineFirst/67373
更新日期：2017-06-18 00:00:00
abstract：:Although, emotions play a crucial role in schizophrenia, the changes in emotional dimension still remain controversial. The aim of our work was: 1) to compare the disorders of emotional control between the examined groups: S--non-chronic schizophrenic patients (n = 50), CS--chronic schizophrenic patients (n = 50), N--...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:Cognitive dysfunctions are part of the symptomatology of depressive disorders but they may persist even after the patient reaches symptomatic remission. As persistent symptoms of depression, cognitive dysfunctions may inhibit and restrict the patient's functioning in many spheres and significantly impair its quality. ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/OnlineFirst/105415
更新日期：2020-06-30 00:00:00
abstract：AIM:The aim of our work was to assess qualitatively and quantatively emotional deficits in patients diagnosed with schizophrenia following ICD-10 criteria in early and late stages of the schizophrenic process and the evaluation of the relationship between genes polymorphism of enzymes influencing dopaminergic, serotoni...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Evaluation of effects of amitriptyline, imipramine, maprotiline, mianserin , clomipramine and citalopram was performed in 84 patients (49 females and 35 males) age on average 40 years with diagnosis of affective psychosis treated in the Department of Psychiatry Medical School of Szczecin. Antidepressants independently...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：:The authors of this article on the basis "Uber die Klassifikation der Psychosen" analysis present the method of mental disorders' classification proposed by Carl Wernicke in 1899. Wernicke's classification was an alternative for other classification concepts existing in the 19th century. Carl Wernicke as one of the fi...
journal_title：Psychiatria polska
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Advancement in research on glication process in pathogenesis of AD is presented. Its results may open new, promising possibilities of treatment of neurodegenerative diseases including AD with inhibitors of glication. ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：:The causes of metabolic brain changes in patients with anorexia nervosa are still not fully explained. The purpose of this study was to use the 1H-MRS method in investigating metabolic changes in the brain of patients with anorexia nervosa. We studied 10 patients for visible alternations in brain metabolism and compar...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVE:to assess the prevalence of obsessive-compulsive disorder (OCD) or OC symptoms in patients with anorexia nervosa (AN) and to find a possible relationship between the presence of OC symptoms and the course of AN. METHOD:137 adolescent female patients with AN, aged 14.8 +/- 1.8 years, completed the Polish vers...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2014-05-01 00:00:00
abstract：INTRODUCTION:The symptoms of dissociation, depersonalization and derealization are often associated with exposure of patients to mental and physical injuries, usually occurring in childhood. Most of these observations were carried out in populations of patients with various disorders (posttraumatic, conversion-dissocia...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/36296
更新日期：2016-01-01 00:00:00
abstract：:Anorexia nervosa (AN) most often has its onset in adolescence, which is a crucial period to achieve peak bone mass. The hormonal abnormalities (hypoestrogenism, hypercortisolism, decreased secretion of dehydroepiandrosterone, testosterone, insulin-like growth factor) and malnutrition are associated with profound bone ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/59289
更新日期：2016-01-01 00:00:00
abstract：:A history of studies on altered states of consciousness is described and divided into five main periods. Contemporary descriptive and psychophysiological research are reviewed. ...
journal_title：Psychiatria polska
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：OBJECTIVES:There are patients with neuropathic pain in whom the treatment is ineffective, despite the fact that is conducted with adherence to the current guidelines. In these patients alternative treatment methods such as hypnosis could be effective. METHODS:The paper presents a case of a 58-year-old man with central...
journal_title：Psychiatria polska
pub_type：
doi：10.12740/PP/40066
更新日期：2016-01-01 00:00:00
