Abstract：
AIM:The aim of our work was to assess qualitatively and quantatively emotional deficits in patients diagnosed with schizophrenia following ICD-10 criteria in early and late stages of the schizophrenic process and the evaluation of the relationship between genes polymorphism of enzymes influencing dopaminergic, serotoninergic, and noradrenergic transfer and emotional functioning of the examined patients. METHOD:In our study the following methods have been used: Short Recognition Memory test for Faces (TPRT), Facial Expression Recognition Test (FERT), "Reading the mind in the eyes" Test and psychiatric scales (SAPS, SANS, BDI) and molecular techniques (PCR reaction, RFLP and VNTR techniques). 100 paranoid schizophrenia patients (43 female and 57 man) and 50 healthy controls (30 female and 20 man) were invited to participate in the study. RESULTS:Our results revealed an association between polymorphism of Val158Met COMT and emotional deficits in schizophrenic patients. Furthermore, the relationship between polymorphism of MAO-A and empathy/theory of mind deficit was found. No relationship was elicited between polymorphism of Val158Met COMT and VNTR MAO-A in the promoter area and schizophrenia onset. Allelic distribution of polymorphism of Val158Met COMT and VNTR MAO-A in the promoter area did not differ between the groups. The patients with genotype Val/Val of polymorphism Val158Met COMT showed major emotional deficits. The patients with genotype of 4/4 of polymorphism VNTR MAO-A showed deeper empathy/theory of mind deficits.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Tylec A,Kucharska-Pietura K,Jeleniewicz W,Czernikiewicz A,Stryjecka-Zimmer Msubject
Has Abstractpub_date
2010-03-01 00:00:00pages
207-19issue
2eissn
0033-2674issn
2391-5854journal_volume
44pub_type
杂志文章abstract：:The aim of this article is to describe a structuralised cognitive group therapy - the meta-cognitive training for schizophrenia patients, developed in 2005 by S. Moritz and T. S. Woodward. This method is based on research results regarding cognitive biases observed in schizophrenia patients, which were briefly describ...
journal_title：Psychiatria polska
pub_type： 杂志文章
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
pub_type： 杂志文章,评审
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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journal_title：Psychiatria polska
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