Abstract：
:Although the development of second-generation antipsychotics was a cornerstone in the treatment of schizophrenia, several unmet treatment needs in the field still exist. It is particularly important to note that available antipsychotics have limited efficacy in the treatment of negative symptoms and cognitive impairment. At this point, it should be noted that primary negative symptoms, i.e., those that are not due to depression, extrapyramidal symptoms or psychotic withdrawal, might affect even one-fourth of patients with schizophrenia and are associated with poor clinical and functional outcomes. Cariprazine, is an emerging antipsychotic drug, D3/D2 receptor partial agonist, with affinity to several serotonin receptors. In this article, we provide an overview of pharmacokinetic and pharmacodynamic properties of cariprazine, showing its unique receptor profile. Next, we discuss results of double-blind, placebo-controlled, randomized clinical trials and post hoc analyses of cariprazine that have been published to date. These studies have provided evidence for efficacy of cariprazine in the treatment of schizophrenia exacerbations compared to placebo, with safety and good tolerability. In addition, one clinical trial published to date revealed superior efficacy of cariprazine compared to risperidone in the treatment of predominant negative symptoms that had been also associated with concomitant improvement of functional performance. Overall, current evidence in the field supports the use of cariprazine in exacerbation of schizophrenia and suggests promising efficacy in the treatment of predominant negative symptoms.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Misiak B,Bieńkowski P,Samochowiec Jdoi
10.12740/PP/OnlineFirst/80710subject
Has Abstractpub_date
2018-12-29 00:00:00pages
971-981issue
6eissn
0033-2674issn
2391-5854pii
80710journal_volume
52pub_type
杂志文章,评审abstract：:Ketamine is a rapid-acting anaesthetic agent which has been used for over 40 years. It is an antagonist of N-methyl-D-aspartate (NMDA) receptors and agonist of mu and sigma opiate receptors. Ketamine acts through inhibition of sensory parts in the brain and stimulation of the limbic system and optic thalamus. The most...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2009-09-01 00:00:00
abstract：:The authors present a comprehensive intensive treatment model of neurosis based on group therapy and on the therapy of psychogenic functional disorders (neuroses) conducted on a day ward. The paper presents the authors' own experience in the Regional Centre for the Treatment of Neuroses (a ward of the Kraków Neuropsyc...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：OBJECTIVES:The objective of the study was to assess the frequency of health and nutritional behaviors concerning emotional, habitual, and restrictive eating as well as to evaluate self efficacy in patientswith morbid obesity and determine the correlation between patients'BMI index and their health behaviors as well as ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/81182
更新日期：2019-10-30 00:00:00
abstract：UNLABELLED:AIM : Current studies show that diabetic patients are at greater risk of developing psychiatric disorders than general population. The aim of this study was to evaluate the frequency of depressive symptoms in school-aged children with type 1 diabetes (T1D). METHODS:The study involved 477 children with T1D, ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/35649
更新日期：2015-01-01 00:00:00
abstract：:We introduce a case of an 18 years old man suspected of murder attempt of his colleague. We made a diagnosis of immature personality with schizoid features; we also want to remind Edward Brzezicki's thoughts on paragnomen. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
abstract：:There is growing interest in the role of Dehydroepiandrosteron (DHEA) in depression. To evaluate the validity of its administration in depression, the role of DHEA in the mechanism of depression and cardiovascular risk, as so the results of clinical trials must be considered. According to accessible literature, both c...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2009-05-01 00:00:00
abstract：:The authors discuss the concept of systemic diagnosis and its logical and scientific validity. A diagnosis is the result of the "diagnostic process", with the presence of the acting object (the person making the diagnosis) and the subject (the individual or group patient, such as family), between whom there is a skew ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：AIM:The objective of the study was to assess the relation between the occurrence of deliberate self-harm (DSH) in young patients during their psychiatric treatment and the presence of specific mental disorders, or the history of suicide attempts, the exposure to abuse and their family situation. METHOD:The studied gro...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：AIM:Qualitative analysis of acute psychiatric patients' subjective opinions on the conditions and effects of their hospital treatment. Presentation of patients' expectations in this respect and the follow up of the opinion changes taking place during hospital stay. METHOD:Patients' opinions were obtained in open quest...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：AIM:The aim of the study was to determine the image of female-to-male transsexuals (FtM) in the opinion of women and men. Methods. The questionnaire studies were carried out in a group of 300 students. Respondents answered questions concerning their age, sex, birthplace and the questions related to different aspects of...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
abstract：:10 patients suffering from reactive psychoses were treated in a standardized manner with pernazine. The dynamic of the clinical picture as well as the behaviour of prolactin levels and the activity of DBH in blood plasma were assessed. ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：AIM:To evaluate the efficacy of cognitive behavioral therapy (CBT-I) in chronic insomnia treatment. METHOD:236 patients with ICD- 10 nonorganic insomnia were assigned to group CBT-I (6 sessions, 6-10 patients). From this pool, 72 participants with no history of other psychiatric or sleep disorders conditions were sele...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：INTRODUCTION:Clinical observations suggest that the Brief Measure to Assess Perception of Self-Influence on the Disease Course: A Version for Schizophrenia has the better reliability, than presented in the original publication of the scale [1]. It is used in research and their results indicate moderate relations betwee...
journal_title：Psychiatria polska
pub_type： 信件
doi：10.12740/PP/43441
更新日期：2015-05-01 00:00:00
abstract：:Since at least 20 years, most of the legal proceedings of marital incapacity are carried on by the church tribunals mainly of no 3 canon 1095 new law code, that is of mental incapacity to undertaking and performing the essential marital duties. Very often the legal proceedings are very difficult and the canonical lawy...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：:Thirty eight years after the successful clinical introduction of antidepressant agents, there has been an important progress in the knowledge and changes in thinking about the role of central serotonergic system in depression and in the mechanism of their therapeutic efficacy. Although it is not clear whether an incre...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：1996-11-01 00:00:00
abstract：:Two groups of male patients were investigated: 19 subjects with diagnosis of paranoid schizophrenia and 13 with schizoaffective psychosis (8 with both depressive and paranoid symptoms, 5 with manic and paranoid). All patients were treated with perazine in this same manner. During the consecutive stages of therapy the ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1990-09-01 00:00:00
abstract：:Caregiver burden was evaluated among family members of 90 schizophrenic patients from hospital psychiatric ward, day hospital or from community psychiatry unit. Psychopathology was evaluated with the use of PANSS while family burden with the use of Tessler's scale which allowed to differentiate between objective and s...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：:The authors describe a new rehabilitation unit i.e. The Occupational Therapy Workshops, which were established on the basis of the Decree of Minister of Work and Social Politics. The paper consists of: 1) the law, regulations and rules; 2) experience gathered during one-year period of workshops functioning at the Inst...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1995-05-01 00:00:00
abstract：AIM:The aim of our work was to assess qualitatively and quantatively emotional deficits in patients diagnosed with schizophrenia following ICD-10 criteria in early and late stages of the schizophrenic process and the evaluation of the relationship between genes polymorphism of enzymes influencing dopaminergic, serotoni...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2010-03-01 00:00:00
abstract：:Clinical involvement of the nervous system occurs in about 5% of patients with sarcoidosis. We describe a fatal case of a young patient with neurosarcoidosis with a relatively rare psychotic syndrome in the course of neurosarcoidosis, presenting itself as a depressive syndrome with delusions. The neurological manifest...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-11-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the supply of selected vitamins and minerals in the daily food rations of patients diagnosed with schizophrenia. METHODS:62 schizophrenia patients (32 women and 30 men aged 21-64, the mean age of women was 41.3 ± 11.2, the mean age of men was 36.1 ± 9.7) took part in the s...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/92280
更新日期：2019-06-30 00:00:00
abstract：:Advancement in research on glication process in pathogenesis of AD is presented. Its results may open new, promising possibilities of treatment of neurodegenerative diseases including AD with inhibitors of glication. ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-11-01 00:00:00
abstract：:A group of 50 patients aged from 12 to 20 with anorexia nervosa was examined: 40 persons with a diagnosis of restricting type and 10 with binge-eating type according to DSM IV. The level of intelligence quotient (IQ) was estimated by using Wechsler Test, selfacceptation by SQ and aspiration by TAT and test of unfinish...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVES:Physical symptoms related to cancer are associated with various mental conditions. An adopted attitude towards pain and disease affects the quality of life of patients and may even decide about the final outcome of therapy. The objective of the study was to assess the degree of mental adjustment of patients ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/44732
更新日期：2018-02-28 00:00:00
abstract：:A history of studies on altered states of consciousness is described and divided into five main periods. Contemporary descriptive and psychophysiological research are reviewed. ...
journal_title：Psychiatria polska
pub_type： 历史文章,杂志文章,评审
doi：
更新日期：1992-11-01 00:00:00
abstract：:Many studies of schizophrenic brains indicate the dysfunction of dopamine and glutamate systems in the prefrontal and frontal cortex. It seems that better understanding of mechanisms regulating functions of these neuronal cortical systems could contribute to creation of new drugs acting in the cortex selectively. This...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：AIM:The difficulties in social functioning of the mentally ill are widely documented in specialist literature. The social affects addressed to the mentally disabled are an attempt to overcome this particular disability. The aim of the presented research is the characterization of the social group participating in a com...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2009-07-01 00:00:00
abstract：:Amisulpride is an antipsychotic available in Europe since 1990s, in Poland since 2000. Subsequent years brought to Polish market more second-generation compounds such as ziprasidone and aripiprazole. In 2018, the Agency for Health Technology Assessment and Tariff System issued positive recommendation for lurasidone in...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/OnlineFirst/109129
更新日期：2020-10-31 00:00:00
abstract：AIM:The aim of the present study was to examine basic psychometric properties as well as to confirm the five-factor structure of the Polish version ofthe Metacognitions Questionnaire-30 (MCQ-30), a short instrument to measure various aspects of maladaptive metacognitions. METHOD:The sample consisted of 315 individuals...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：AIM:The purpose of the study was the estimation of comorbidity of depressive syndromes and anorexia nervosa (based on criteria of ICD-10 and DSM-IV). A group of 30 children (average age--13.5), 27 girls and 3 boys suffering from a first episode of anorexia nervosa was considered. METHOD:Anamnesis from patients and the...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
