[The role of serotonergic system in the mechanism of action of antidepressant agents].

Abstract:

:Thirty eight years after the successful clinical introduction of antidepressant agents, there has been an important progress in the knowledge and changes in thinking about the role of central serotonergic system in depression and in the mechanism of their therapeutic efficacy. Although it is not clear whether an increase or decrease in serotoninergic function is more important in antidepressant action of agents, there is increasing evidence that almost all antidepressant drugs can induce changes in the sensitivity of somotodendritic 5-HT1A autoreceptors and postsynaptic 5-HT2 receptors in spite of very different pharmacological profiles after a single administration. The question arises as to the causal nature of the relationship between these effects and beneficial clinical action. Further studies are still required to dispel these doubts.

journal_name

Psychiatr Pol

journal_title

Psychiatria polska

authors

Wielosz M

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

963-72

issue

6

eissn

0033-2674

issn

2391-5854

journal_volume

30

pub_type

杂志文章,评审
  • [The role of a psychiatrist in treatment and recovery process of persons suffering from schizophrenia].

    abstract:OBJECTIVES:Research results indicate that possibility of building a therapeutic relationship in schizophrenia treatment facilitates better functioning, more effective reduction in psychotic symptoms and fulfillment of patients' personal goals. The aim of the present study was to investigate whether patients systematica...

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    pub_type: 杂志文章

    doi:10.12740/PP/31505

    authors: Sawicka M,Charzyńska K

    更新日期:2015-03-01 00:00:00

  • [Interferon theory of schizophrenia].

    abstract::The author presents a literature review of the eventual role of interferon in the etiopathogenesis of schizophrenia. Research material is presented of 20 chronic schizophrenic patients treated with Hu-alpha which seems to substantiate the beneficial effects of this substance in some cases which are resistant to curren...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Leszek J

    更新日期:1992-09-01 00:00:00

  • [Evaluation of the activity of selected elements of the immune system in depression].

    abstract:AIM:The evaluation of the activity of selected elements of the immune system in depression. METHOD:Lymphocyte subsets evaluation (CD3+, CD4+, CD8+, CD16+, CD19+, CD4/CD8) was performed in 32 patients with depression (21 women and 11 men in the age from 21 to 66 years) using the flow cytometry method. The cytokine eval...

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    pub_type: 杂志文章

    doi:

    authors: Wójciak P,Sobieska M,Kostrzewa A,Rybakowski J

    更新日期:2007-09-01 00:00:00

  • [Premorbid adjustment of 100 hospitalized adolescent patients].

    abstract::Premorbid adjustment of 100 hospitalized adolescent patients and its correlation with some clinical variables was assessed and compared with a group of 100 healthy adolescents. The hospitalized group of patients was divided into four diagnostic subgroups according to the diagnostic criteria of ICD 9: psychoses, neuros...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Małkiewicz-Borkowska M,Namysłowska I,Osiecka-Doniec E,Puzyńska E,Witkowska-Ulatowska H,Iwanek A

    更新日期:1994-09-01 00:00:00

  • [Communication and speech disorders and their relationship with psychic development and mental disorders in 8 year old children from the Lódź area].

    abstract:AIM:The aim of the study was to analyze the occurrence of communication and speech disorders among 8-year-old children in Lódź. The comorbidity of these disorders with mental and somatic disorders was also analysed. We have also studied the correlation between the level of language development and the level of psychic ...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Kolasińska M,Rabe-Jabłońska J

    更新日期:2005-03-01 00:00:00

  • [The affective disorder-related burden imposed on the family environment--an overview].

    abstract::The family burden (FB) has been defined as a multidimensional impact imposed by an illness on caregivers. FB can be divided into objective (i.e. related to measurable problems) and subjective one (i.e. related to caregivers' emotions arising in response to objective difficulties). FB is known to be related to disturba...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Borowiecka-Kluza JE,Miernik-Jaeschke M,Jaeschke R,Siwek M,Dudek D

    更新日期:2013-07-01 00:00:00

  • [Interpretations of hallucinations resolution by patient with chronic schizophrenia--case report].

    abstract:AIM:The aim of this case description is the analysis of psychotic symptoms resolution in the context of theory of psychosis as a state of aberrant salience. According to that theory both formation and treatment of psychotic symptoms can be seen in two interconnected dimensions: neurobiological perspective of dopamine h...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Murawiec S,Krzystoszek B

    更新日期:2009-03-01 00:00:00

  • [The influence of infertility on women's personality].

    abstract::The purpose of this investigation was to analyze several personality dimensions including several psychopathological symptoms of women experiencing infertility. 70 females experiencing infertility and 50 healthy women were examined using psychological methods: MMPI and the State-Trait Anxiety Inventory by Spielberger,...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Janczur-Bidzan M

    更新日期:1995-07-01 00:00:00

  • [Self-harm done by young patients during their psychiatric hospitalization in relation to the presence of specific mental disorders and chosen environmental factors].

    abstract:AIM:The objective of the study was to assess the relation between the occurrence of deliberate self-harm (DSH) in young patients during their psychiatric treatment and the presence of specific mental disorders, or the history of suicide attempts, the exposure to abuse and their family situation. METHOD:The studied gro...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Warzocha D,Gmitrowicz A,Pawełczyk T

    更新日期:2008-09-01 00:00:00

  • [Impact of treatment with acetylcholinesterase inhibitors, valproic acid and antipsychotics on aggressive behaviour in Alzheimer's type dementia].

    abstract:UNLABELLED:Aggressive and impulsive behaviour are common in Alzheimer's dementia. Therapy of these disorders is an important but difficult practical question. AIM:The purpose of this study was to determine the effect of pharmacological treatment of aggressive behaviour, while taking into account the dynamics of diseas...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Bidzan L,Grabowski J,Dutczak B,Bidzan M

    更新日期:2012-05-01 00:00:00

  • [Depression in children: prospective studies].

    abstract::Prospective longitudinal observation of children socially and emotionally immature and depressive at entering school was carried on till their early adolescence. The study's aim was to describe: 1. childhood depression dynamics, 2. developmental changes in depression, 3. factors related to the depression course, 4. re...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Bomba J,Jaklewicz H

    更新日期:1997-11-01 00:00:00

  • Editorial.

    abstract::no summary. ...

    journal_title:Psychiatria polska

    pub_type: 社论

    doi:10.12740/PP/75519

    authors: Dudek D,Sobański JA,Klasa K

    更新日期:2017-08-29 00:00:00

  • [Prevalence of potentially reversible cognitive function disorders in patients of a memory dysfunction clinic].

    abstract:UNLABELLED:Potentially reversible dementias are rarely detected in out-patient care facilities. Actual reversibility is virtually not known and has been occasionally reported in literature. AIM:To determine the prevalence of potentially reversible dementias among patients seen at the ambulatory care facility and to es...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Sobów T,Wojtera M,Kłoszewska I

    更新日期:2006-09-01 00:00:00

  • [Dehydroepiandrosteron (DHEA) in the mechanisms of stress and depression].

    abstract::There is growing interest in the role of Dehydroepiandrosteron (DHEA) in depression. To evaluate the validity of its administration in depression, the role of DHEA in the mechanism of depression and cardiovascular risk, as so the results of clinical trials must be considered. According to accessible literature, both c...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Załuska M,Janota B

    更新日期:2009-05-01 00:00:00

  • [On controversies around the Oedipus Complex].

    abstract::In the article the author would like to draw the readers' attention to one of the central issues of psychoanalysis, i.e. Oedipus complex. In the development of the psychoanalysis the classical conception of Oedipus complex presented by Freud gave rise to a severe criticism both on the part of some psychoanalysts, espe...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Drwiega M

    更新日期:2002-11-01 00:00:00

  • Social support and sense of life in patients with anxiety disorders - preliminary report.

    abstract:OBJECTIVES:Verification of the level of social support perception and sense of life in patients with anxiety disorder and healthy people; evaluation of the relationship between these variables. METHODS:The Social Support Questionnaire short version (F-SozU K-22) by G. Sommer and T. Fydrich and the Life Attitude Profil...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:10.12740/PP/81447

    authors: Kroplewski Z,Serocka A,Szcześniak M

    更新日期:2019-04-30 00:00:00

  • Does the usual dietary intake of schizophrenia patients require supplementation with vitamins and minerals?

    abstract:OBJECTIVES:The aim of the study was to assess the supply of selected vitamins and minerals in the daily food rations of patients diagnosed with schizophrenia. METHODS:62 schizophrenia patients (32 women and 30 men aged 21-64, the mean age of women was 41.3 ± 11.2, the mean age of men was 36.1 ± 9.7) took part in the s...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:10.12740/PP/92280

    authors: Stefańska E,Wendołowicz A,Lech M,Konarzewska B,Zapolska J,Waszkiewicz N,Ostrowska L

    更新日期:2019-06-30 00:00:00

  • [P50 component of auditory evoked potentials in persons with schizophrenia and their first degree relatives].

    abstract:UNLABELLED:A pair of auditory stimuli presented in a 0.5 second interval cause a reduction of the P50 auditory evoked potential (P50 AEP) amplitude after the second stimuli in the pair. In some, but not all studies, a clear deficit of such P50 AEP gating was observed in schizophrenic patients. It was present constantly...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Wegrzyn J,Wciórka J

    更新日期:2004-05-01 00:00:00

  • [Study of the protein glycation in Alzheimer's disease].

    abstract::Advancement in research on glication process in pathogenesis of AD is presented. Its results may open new, promising possibilities of treatment of neurodegenerative diseases including AD with inhibitors of glication. ...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Leszek J,Gamian A,Kiejna A

    更新日期:2002-11-01 00:00:00

  • [Regional cerebral blood flow in depression].

    abstract::In the review article, the results of studies on regional cerebral blood flow (rCBF) in major depression are presented. Most studies have reported global and regional deficits in cerebral blood flow in major depression as compared to healthy controls. Longitudinal studies show that after recovery from depression an in...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Jaracz J

    更新日期:1999-07-01 00:00:00

  • [Problems of psychogeriatrics].

    abstract::The author discusses the present state and needs of psychogeriatry in Poland. He considers the situation within the period of 33 years, which, in his opinion, has not been distinctly improved in spite of growth of old age disorders and various psycho-social threats connected with economical difficulties. The author di...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Bilikiewicz A

    更新日期:1995-09-01 00:00:00

  • [Self-concept, alkohol expectancies and drinking habits in high school students].

    abstract:AIM:The study was aimed at finding relationships between self-concept, alcohol expectancies and drinking in the group of high school students. It was expected that a higher level of alcohol consumption was related to lower self-concept and positive expectancies concerning alcohol use. METHOD:The group of 229 Polish hi...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Łosiak W

    更新日期:2008-05-01 00:00:00

  • Pain and tactile dissociation, derealization and depersonalization symptoms in women and recalled traumatic events in childhood, adolescence and early adulthood.

    abstract:INTRODUCTION:The symptoms of dissociation, depersonalization and derealization are often associated with exposure of patients to mental and physical injuries, usually occurring in childhood. Most of these observations were carried out in populations of patients with various disorders (posttraumatic, conversion-dissocia...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:10.12740/PP/OnlineFirst/36296

    authors: Smiatek-Mazgaj B,Sobański JA,Rutkowski K,Klasa K,Dembińska E,Müldner-Nieckowski Ł,Cyranka K,Mielimąka M

    更新日期:2016-01-01 00:00:00

  • [Wernicke's classification and others concepts of classifying mental disorders].

    abstract::The authors of this article on the basis "Uber die Klassifikation der Psychosen" analysis present the method of mental disorders' classification proposed by Carl Wernicke in 1899. Wernicke's classification was an alternative for other classification concepts existing in the 19th century. Carl Wernicke as one of the fi...

    journal_title:Psychiatria polska

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Pawłowski T,Kiejna A

    更新日期:2003-01-01 00:00:00

  • [Assessment of efficacy and tolerability of mirtazapine treatment of patients with depression].

    abstract::The paper presents results of the study on the efficacy and tolerability of mirtazapine treatment of patients with depression. The study was open and conducted in three centers. 65 out- and in-patients with diagnosis of depression was included. 50% reduction of the score in the HAM-D scale was obtained in 57%, accordi...

    journal_title:Psychiatria polska

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Beszłej A,Grzesiak M

    更新日期:2002-11-01 00:00:00

  • [Pro- and antioxidant processes in schizophrenics with tardive dyskinesia].

    abstract:UNLABELLED:Central nervous system diseases are connected with the production of an increased amount of reactive oxygen species. Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia (TD) in schizophrenic patients in a prolonged neuroleptic treatment course. AIM:Evaluation of superoxid...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Gałecki P,Pietras T,Florkowki A

    更新日期:2005-11-01 00:00:00

  • [Cognitive training: prospects and limitations of the new form of rehabilitation in schizophrenia].

    abstract::The impressive developments in research on disturbances of information processing in schizophrenia initiated the effort directed toward correction of these deficits. Studies on cognitive rehabilitation have generated some promising findings regarding the improvements in patients' cognitive and clinical status. However...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:

    authors: Nieznański M

    更新日期:2000-03-01 00:00:00

  • Barriers in the access to alcohol treatment in outpatient clinics in urban and rural community.

    abstract:OBJECTIVES:The aim of the study was identification of the barriers making it notably more challenging to access clinics in urban and rural communities. METHODS:The method, which was used in this study adopts the qualitative research perspective. The research tool was an interview with a standardized list of desired in...

    journal_title:Psychiatria polska

    pub_type: 杂志文章

    doi:10.12740/PP/60345

    authors: Wieczorek Ł

    更新日期:2017-02-26 00:00:00

  • [Mental disturbances in persons persecuted for political reasons in Poland in the years 1944-1955].

    abstract::The paper presents the results of studies on the present state of mental health in persons persecuted for political reasons in Poland in the years 1944-1955. Symptoms of mental disturbances were detected in nearly all examined group. PTSD criteria were applied in the diagnosis. ...

    journal_title:Psychiatria polska

    pub_type: 历史文章,杂志文章

    doi:

    authors: Heitzman J,Rutkowski K

    更新日期:1997-03-01 00:00:00

  • [New diagnostic criteria for the neuropsychiatric form of systemic lupus erythematosus].

    abstract::Systemic lupus erythematosus (SLE) is an autoimmunologic illness, which apart from changes in the skin, the locomotor system and the internal organs, attacks also the nervous system. The paper presents 19 neuropsychiatric symptomic syndromes which after conduction of multidisciplinary, international research were acce...

    journal_title:Psychiatria polska

    pub_type: 杂志文章,评审

    doi:

    authors: Koseda-Dragan M,Hebanowski M,Badzio-Jagiełło H,Lass P,Banecka-Majkutewicz Z,Krześniak-Bohdan M,Nowicka-Sauer K

    更新日期:2000-11-01 00:00:00