Abstract:
UNLABELLED:A pair of auditory stimuli presented in a 0.5 second interval cause a reduction of the P50 auditory evoked potential (P50 AEP) amplitude after the second stimuli in the pair. In some, but not all studies, a clear deficit of such P50 AEP gating was observed in schizophrenic patients. It was present constantly irrespective of the clinical state. This deficit was also found in first degree relatives of schizophrenic patients. However the results of the studies, as well as their interpretation remain controversial. AIM:To differentiate between P50 AEP in groups of schizophrenic patients, their healthy first degree relatives, as well as those in the control group. METHOD:50 schizophrenic patients (ICD-10 criteria (DCR)) in early clinical improvement phase, 26 healthy first degree relatives, as well sa 46 healthy individuals with no psychiatric illness in the self-report and family history. All those studied were stimulated with 120 pairs of auditory stimuli (clicks), each of duration 2 mseconds and a sound intensity of 73 dB, with a 500 msecond interval between the stimuli in a pair (S1 and S2) every 8 seconds. A high-end filter of 70 Hz and low-end filter of 10 Hz were applied. Bio potentials were recorded from the head apex, relatively to the mastoid process (A1 + A2). Eyeball-movement artefacts were registered from the Fp1-A1 and Fp2-A2 potentials. The registered bio potentials were evened on-line. RESULTS:Relative (i.e. evaluated in relation to the potential after S1) lowering of the P50 potential after S2 was the most significant in the healthy control group (75%), in the other groups usually there was an increase in the S2 potential--higher in the schizophrenic patient group (-45%) and lower in their first degree relatives (-11%). CONCLUSIONS:(1) Healthy individuals suppressed the neurophysiologic response to the second pair of auditory stimuli much more than the schizophrenic patients and their healthy families. (2) No difference was seen in the suppression of the response between the schizophrenic patients and their first degree relatives. The results are coherent with the idea of the dysfunction of the P50 gating having endophenotypic traits as far as schizophrenia goes.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Wegrzyn J,Wciórka Jsubject
Has Abstractpub_date
2004-05-01 00:00:00pages
395-408issue
3eissn
0033-2674issn
2391-5854journal_volume
38pub_type
杂志文章abstract::Advancement in research on glication process in pathogenesis of AD is presented. Its results may open new, promising possibilities of treatment of neurodegenerative diseases including AD with inhibitors of glication. ...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00
abstract::Prospective longitudinal observation of children socially and emotionally immature and depressive at entering school was carried on till their early adolescence. The study's aim was to describe: 1. childhood depression dynamics, 2. developmental changes in depression, 3. factors related to the depression course, 4. re...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::Schizophrenia is an illness with a large variety of symptoms, significant variability of the individual course, and still not fully explained etiology. It is suggested that genetic, infectious and immunological factors may be involved, and neurodevelopmental, neurodegenerative and neurotransmitter hypotheses have been...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:10.12740/PP/114952
更新日期:2020-08-31 00:00:00
abstract::Up to 30% of medical students suffer from depression. They have better access to healthcare, but still receive appropriate treatment less frequently than people with depression in the general population. Most of them do not seek medical help as depression is perceived as a stigmatizing disorder, which leads to self-st...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:10.12740/PP/OnlineFirst/67373
更新日期:2017-06-18 00:00:00
abstract:OBJECTIVES:The aim of the study was to explore the relationship between various areas of self-image and defence mechanisms in adolescents. The study included a division into groups according to whether or not they were receiving psychiatric treatment. METHODS:Data were obtained from two groups: a clinical group (30 pe...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/30017
更新日期:2015-01-01 00:00:00
abstract::Amisulpride is an antipsychotic available in Europe since 1990s, in Poland since 2000. Subsequent years brought to Polish market more second-generation compounds such as ziprasidone and aripiprazole. In 2018, the Agency for Health Technology Assessment and Tariff System issued positive recommendation for lurasidone in...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:10.12740/PP/OnlineFirst/109129
更新日期:2020-10-31 00:00:00
abstract::Basing on the latest world literature the paper presents the profile of pharmacological and clinical effects of sulpiride, an atypical neuroleptic which has only recently become available in Poland. The author promotes the clinical application of sulpiride. ...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::A group of 50 patients aged from 12 to 20 with anorexia nervosa was examined: 40 persons with a diagnosis of restricting type and 10 with binge-eating type according to DSM IV. The level of intelligence quotient (IQ) was estimated by using Wechsler Test, selfacceptation by SQ and aspiration by TAT and test of unfinish...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract::The aim of the second part of our work associated with psychopharmacotherapy during pregnancy and lactation is to present current guidelines of expert-groups concerning the rules of treating affective disorders and actual data about the spreading of these disorders pre- and perinatal effects of drugs used, the classif...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-01 00:00:00
abstract::The paper presents a review of recent data on research and clinical significance of gating of the P50 component of the auditory evoked potentials (AEP). Information filters are a necessary element for the proper functioning of the brain. It appears as though they have an important role in the information-transfer mech...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00
abstract::Ketamine is a rapid-acting anaesthetic agent which has been used for over 40 years. It is an antagonist of N-methyl-D-aspartate (NMDA) receptors and agonist of mu and sigma opiate receptors. Ketamine acts through inhibition of sensory parts in the brain and stimulation of the limbic system and optic thalamus. The most...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
abstract::A group of 90 hospitalized patients suffering from paranoid schizophrenia were examined and than compared with parallel group of 90 healthy volunteers. The following methods of examinations were used: Plutchick's LSI-Test, Spilberger's STAI-Test, Szustowa's Egocentric Association Test and an Inventory of Self-Descript...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::no summary. ...
journal_title:Psychiatria polska
pub_type: 社论
doi:10.12740/PP/75519
更新日期:2017-08-29 00:00:00
abstract::The author discusses the metabolism of disulfiram and the enzymes which metabolize ethanol. The restraining of the activity of ALDH in the liver by disulfiram causes an accumulation of acetaldehyde which in their turn cause a series of psychophysical symptoms which are unpleasant and in some instances dangerous for th...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:1992-09-01 00:00:00
abstract::The causes of metabolic brain changes in patients with anorexia nervosa are still not fully explained. The purpose of this study was to use the 1H-MRS method in investigating metabolic changes in the brain of patients with anorexia nervosa. We studied 10 patients for visible alternations in brain metabolism and compar...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract::The authors describe the case of a female patient with the diagnosis of schizophrenia and the CYP2D6 poor metaboliser phenotype (PM phenotype), who experienced severe extrapyramidal side effects, including acute dystonia, while being treated with chloropromazine at 100 mg per day (in the third day of therapy). The CYP...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::The aim of the literature review was the problem of psychiatric complications of intensive chemo- and radiotherapy, which were used in childhood. These days most children who suffer from acute leukaemia are successfully treated. Most studies indicate cognitive dysfunctions, anxiety and mood disorders. These days a new...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract:AIM:Ischaemic heart disease (IHD) tops the list of sick and death rates all over the world. IHD brings the risk of central nervous system disturbances. On the other hand lower neuropsychological tests results enable to predict cardiac relapse. We assess the neuropsychological function such as working memory and executi...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2013-01-01 00:00:00
abstract::Social reactions for mental diseases are very complex, because contacts between healthy people and the ill ones are limited in our society. People are afraid of all symptoms of mental disability and they think that such people should be isolated in closed institutions. The majority of examined people (79%) think that ...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::The aim of this study was evaluation of selected immune humoral indicators in connection with biochemical parameters of blood in 28 alcohol dependent men. Increased activity of liver enzymes: AspAT in 53,6% of patients, A1AT in 46,4%, GGTP in 25% were found. Macrocytosis in 29% of patients was observed. There were als...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::no summary. ...
journal_title:Psychiatria polska
pub_type: 社论
doi:10.12740/PP/68707
更新日期:2017-02-26 00:00:00
abstract::Plasma cortisol level was measured 7 times between 3 and 5 pm in 34 inpatients with major depression and 25 controls. 1 mg of dexamethasone per os was administrated the day before a 11 pm. The maximum, minimum, mean and range of cortisol concentration were calculated. All these parameters were statistically significan...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:AIM:The aim of paper was to assess parameters characterising fluctuation of afternoon cortisol level in a group of patients with major depression compared to matched healthy controls. METHOD:34 inpatients (21 women and 13 men) with major depression and 28 matched healthy controls (18 men and 10 men) were included in t...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
abstract::There is growing interest in the role of Dehydroepiandrosteron (DHEA) in depression. To evaluate the validity of its administration in depression, the role of DHEA in the mechanism of depression and cardiovascular risk, as so the results of clinical trials must be considered. According to accessible literature, both c...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2009-05-01 00:00:00
abstract:AIM:The aim of this article is partial empirical verification of the depression image theoretical concept underlying the KID IO"C1" construction, and also, a check of the questionnaire's factor relevancy. METHOD:KID results of a study of an untreated population sample of 17-year-olds were analysed statistically. Out o...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to prepare the Polish adaptation of the Young Schema Questionnaire S3-PL. The scale is a self-assessment tool designed to measure 18 early maladaptive schemas. METHODS:The sample consists of 1,529 adults (927 women and 585 men), aged 18-85 years (mean age was 32 years), from non-cli...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/OnlineFirst/76541
更新日期:2018-08-24 00:00:00
abstract::89 patients (52 women and 37 men) with bipolar affective disorder was separated on two groups: with alcohol problems (n = 30) and without alcohol problems (n = 59). Both groups were tested using Scale of Adaptation and Activity of Puzyński (SAA III). The bipolar affective illness discriminates patient's social functio...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVES:The military service of Polish soldiers on missions abroad began in 1953. Many years of experience of the Polish army as well as the armed forces of other countries show that being in a mission area has a significant impact on soldiers' mental health. Soldiers experience problems with anxiety disorders, depr...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/OnlineFirst/75666
更新日期:2018-10-27 00:00:00
abstract:OBJECTIVES:Physical symptoms related to cancer are associated with various mental conditions. An adopted attitude towards pain and disease affects the quality of life of patients and may even decide about the final outcome of therapy. The objective of the study was to assess the degree of mental adjustment of patients ...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/OnlineFirst/44732
更新日期:2018-02-28 00:00:00
abstract::In the inauguration speech of the Congress stages of the path taken by the Polish Psychiatric Society were described in short: 1--The period from its establishment till 1939; 2--Tragic years of the war, 1939-1945, with extermination of ca. 20,000 patients and many psychiatrists; 3--Reconstruction after the war, accomp...
journal_title:Psychiatria polska
pub_type: 历史文章,杂志文章
doi:
更新日期:1999-01-01 00:00:00