Abstract:
:The authors describe the case of a female patient with the diagnosis of schizophrenia and the CYP2D6 poor metaboliser phenotype (PM phenotype), who experienced severe extrapyramidal side effects, including acute dystonia, while being treated with chloropromazine at 100 mg per day (in the third day of therapy). The CYP2D6 phenotype was determined using the sparteine test before and after 3 days of treatment. Metabolic ratio increased 12 times during treatment, from initial 30 to 355. The authors conclude that CYP2D6 poor phenotype leading to slow chloropromazine metabolism, which was further inhibited by chloropromazine during treatment (as chlorpromazine is a strong CYP2D6 enzyme inhibitor) had significant importance on the occurrence of acute extrapyramidal side effects. Most likely the antidopaminergic influence of the drug on the CNS was much more marked due to an inhibition of chlorpromazine metabolism leading probably to an increase of the chlorpromazine blood level.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Beszłej JA,Grzesiak M,Milejski Psubject
Has Abstractpub_date
2007-07-01 00:00:00pages
495-501issue
4eissn
0033-2674issn
2391-5854journal_volume
41pub_type
杂志文章abstract::The aim of the literature review was the problem of psychiatric complications of intensive chemo- and radiotherapy, which were used in childhood. These days most children who suffer from acute leukaemia are successfully treated. Most studies indicate cognitive dysfunctions, anxiety and mood disorders. These days a new...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-01-01 00:00:00
abstract::Investigations of cerebral blood flow and metabolism provide interesting data concerning specific brain regions involved in depression. The objective of this paper is to present to Polish readers results of studies using PET in patients with depression. Provocation of transient sadness in healthy subjects during clini...
journal_title:Psychiatria polska
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journal_title:Psychiatria polska
pub_type: 历史文章,杂志文章
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pub_type: 杂志文章,评审
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journal_title:Psychiatria polska
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journal_title:Psychiatria polska
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doi:
更新日期:2004-03-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
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更新日期:2005-09-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
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journal_title:Psychiatria polska
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doi:
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Psychiatria polska
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doi:
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Psychiatria polska
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doi:
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
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journal_title:Psychiatria polska
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doi:
更新日期:2003-09-01 00:00:00
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journal_title:Psychiatria polska
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