Abstract:
UNLABELLED:Central nervous system diseases are connected with the production of an increased amount of reactive oxygen species. Decreased antioxidant activity is considered as one of the causes of tardive dyskinesia (TD) in schizophrenic patients in a prolonged neuroleptic treatment course. AIM:Evaluation of superoxide dismutase, catalase, glutathione peroxidase activity as well as lipid peroxidation by TBARS saturation in blood platelets in schizophrenic patients with or without tardive dyskinesia symptoms. METHOD:84 paranoid schizophrenic patients took part in the study, 40 of them with TD symptoms. The groups were comparative in clinical and demographic terms. Indication of TBARS in blood platelets was performed by the Placed and coop method. GSH-Px activity was indicated by the Little and O'Brien method. CAT activity was indicated according to the Beers and coop method. CuZnSOD activity in blood platelets was indicated by the Mirsa and Fridovich method. RESULTS:CuZnSOD activity in schizophrenic patients without TD is 820.23 and accordingly 710.75 U/g in TD symptoms patients and it is statistical essential. TBARS for patients with TD is 1.06 and accordingly without TD it is 0.92 micromol/10(9)), the difference is statistically essential. For groups with and without TD CAT activity is accordingly 19.87 and 17.93 Ub/g. For groups with and without TD GSH-Px is accordingly 32.30 and 30.48 U/g. CONCLUSIONS:schizophrenic patients with TD symptoms have lower CuZnSOD activity and higher concentration of TBARS in platelets than patients without TD. CAT activity is higher in patients with TD symptoms. CuZnSOD activity and concentration of TBARS are in correlation with age in both studied groups.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Gałecki P,Pietras T,Florkowki Asubject
Has Abstractpub_date
2005-11-01 00:00:00pages
1131-41issue
6eissn
0033-2674issn
2391-5854journal_volume
39pub_type
杂志文章abstract::Ketamine is a rapid-acting anaesthetic agent which has been used for over 40 years. It is an antagonist of N-methyl-D-aspartate (NMDA) receptors and agonist of mu and sigma opiate receptors. Ketamine acts through inhibition of sensory parts in the brain and stimulation of the limbic system and optic thalamus. The most...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2009-09-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::Sleep disturbances of insomnia type belong to the most common health problems of the modern society. Chronic insomnia, one that worsens daytime functioning and lasts over one month, occurs in 9 to 15% of the general population of developed countries. Further 15-20% of the population suffers from short term insomnia. W...
journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:AIMS:To validate the Polish version of the Athens Insomnia Scale (AIS), the instrument designed for quantitative measurement of the severity of insomnia based on the ICD-10 criteria. METHOD:The AIS was administered to 356 subjects: 160 patients from the sleep clinic presenting with ICD-10 non-organic insomnia (90f; me...
journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2011-03-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
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journal_title:Psychiatria polska
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doi:
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2012-05-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:10.12740/pp/25834
更新日期:2014-09-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-03-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2002-11-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:10.12740/PP/92392
更新日期:2019-04-30 00:00:00
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journal_title:Psychiatria polska
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1991-05-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/31505
更新日期:2015-03-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/68136
更新日期:2017-10-29 00:00:00
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journal_title:Psychiatria polska
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doi:
更新日期:2009-11-01 00:00:00
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journal_title:Psychiatria polska
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journal_title:Psychiatria polska
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doi:
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journal_title:Psychiatria polska
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doi:
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journal_title:Psychiatria polska
pub_type: 信件
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更新日期:2015-05-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章
doi:10.12740/PP/44238
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
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journal_title:Psychiatria polska
pub_type: 杂志文章,评审
doi:
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