Abstract：
:Many studies of schizophrenic brains indicate the dysfunction of dopamine and glutamate systems in the prefrontal and frontal cortex. It seems that better understanding of mechanisms regulating functions of these neuronal cortical systems could contribute to creation of new drugs acting in the cortex selectively. This might be profitable in cognition of dysfunction and negative symptoms in schizophrenia. This article presents preclinical data concerning the role of 5-HT1A serotonin receptors in the modulation of cortical dopamine system and in psychotomimetic effects of non-competitive NMDA receptor antagonists. Neurochemical studies have shown that 5-HT1A receptor agonists increase dopamine release in the rat prefrontal cortex on the one hand, and they inhibit the augmentation of dopamine release induced by stress or amphetamine, on the other. However, the increase of dopamine release induced by non-competitive NMDA receptor antagonists is blocked by 5-HT1A receptor antagonists. Blockade of 5-HT1A receptors seems to be important also in reduction of most psychotomimetic effects induced by non-competitive NMDA antagonists both involving (locomotor hyperactivity, working memory impair) and not involving (sensorimotor gating deficits) dopamine mechanism. Thus, binding with 5-HT1A receptors can be an important site for the regulation of cortical dopamine system, both in physiological conditions and in disregulation of the system induced by stress, psychostimulants or psychotomimetics. On the other hand, 5-HT1A receptors modulate most of psychotomimetic effects of non-competitive NMDA receptor antagonists. The above results of preclinical investigations indicate that 5-HT1A receptor can be involved in the pathology of schizophrenia, what is partly confirmed by clinical postmortem studies of schizophrenic brains. These studies showed the increase of 5-HT1A receptor density in prefrontal and frontal cortex in schizophrenic brains. It also seems that 5-HT1A receptors might be a good target for the antipsychotic drugs. Although the clinical studies have demonstrated controversial data, maybe further studies using substances with selectivity to 5-HT1A receptors would help to determine more precisely the role of these receptors in pathology and pharmacotherapy of schizophrenia.
journal_name
Psychiatr Poljournal_title
Psychiatria polskaauthors
Maćkowiak M,Czyrak A,Wedzony Ksubject
Has Abstractpub_date
2000-07-01 00:00:00pages
607-21issue
4eissn
0033-2674issn
2391-5854journal_volume
34pub_type
杂志文章,评审abstract：OBJECTIVES:The military service of Polish soldiers on missions abroad began in 1953. Many years of experience of the Polish army as well as the armed forces of other countries show that being in a mission area has a significant impact on soldiers' mental health. Soldiers experience problems with anxiety disorders, depr...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/75666
更新日期：2018-10-27 00:00:00
abstract：:The aim of the second part of our work associated with psychopharmacotherapy during pregnancy and lactation is to present current guidelines of expert-groups concerning the rules of treating affective disorders and actual data about the spreading of these disorders pre- and perinatal effects of drugs used, the classif...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-05-01 00:00:00
abstract：:In recent years increased interest in the connection of intestinal microflora and the state of human health resulted in a great deal of research on the influence of intestinal microflora in particular on mental health, including works on affective functions of the central nervous system (CNS). Previous studies on anim...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/92392
更新日期：2019-04-30 00:00:00
abstract：AIM:The objective of the study was to assess the relation between the occurrence of deliberate self-harm (DSH) in young patients during their psychiatric treatment and the presence of specific mental disorders, or the history of suicide attempts, the exposure to abuse and their family situation. METHOD:The studied gro...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVES:Psychometric evaluation of reliability and usefulness of the Polish version of the CESD-R - a revised version of the CES-D - screening test for depression. METHODS:In an online survey the CESD-R and the Beck Depression Inventory were applied to 260 participants (men and women). Reliability was assessed with...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/61614
更新日期：2016-12-23 00:00:00
abstract：AIM:Qualitative analysis of acute psychiatric patients' subjective opinions on the conditions and effects of their hospital treatment. Presentation of patients' expectations in this respect and the follow up of the opinion changes taking place during hospital stay. METHOD:Patients' opinions were obtained in open quest...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2006-07-01 00:00:00
abstract：:Thirty eight years after the successful clinical introduction of antidepressant agents, there has been an important progress in the knowledge and changes in thinking about the role of central serotonergic system in depression and in the mechanism of their therapeutic efficacy. Although it is not clear whether an incre...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：1996-11-01 00:00:00
abstract：:In the period from 1970 till 1987 forensic psychiatric certification of 1333 delinquents war made in Regional Psychiatric Hospital in Cibórz. Forty experts (3%) regarded subjects aged 60 years or more. The most common crimes were those against life and health--62.5%; predominantly homicides, assaults and assaults on p...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:In the inauguration speech of the Congress stages of the path taken by the Polish Psychiatric Society were described in short: 1--The period from its establishment till 1939; 2--Tragic years of the war, 1939-1945, with extermination of ca. 20,000 patients and many psychiatrists; 3--Reconstruction after the war, accomp...
journal_title：Psychiatria polska
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Social reactions for mental diseases are very complex, because contacts between healthy people and the ill ones are limited in our society. People are afraid of all symptoms of mental disability and they think that such people should be isolated in closed institutions. The majority of examined people (79%) think that ...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：UNLABELLED:A pair of auditory stimuli presented in a 0.5 second interval cause a reduction of the P50 auditory evoked potential (P50 AEP) amplitude after the second stimuli in the pair. In some, but not all studies, a clear deficit of such P50 AEP gating was observed in schizophrenic patients. It was present constantly...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：:In recent years, data on the possibility of rapid clinical improvement after administration of ketamine in patients diagnosed with depression have been published more frequently. Ketamine, used as an anaesthetic during ECT procedures, despite earlier concerns, has both: a good safety profile and minimal effect on seiz...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/31748
更新日期：2015-01-01 00:00:00
abstract：OBJECTIVES:Analyzing the indices that allow to improve population health by, for example, improving the quality of healthcare services and increasing accessibility to these services is among the priorities of the World Health Organization (WHO). This is of particular importance in Poland, as the psychiatric care reform...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/OnlineFirst/92219
更新日期：2019-12-31 00:00:00
abstract：OBJECTIVES:Research results indicate that possibility of building a therapeutic relationship in schizophrenia treatment facilitates better functioning, more effective reduction in psychotic symptoms and fulfillment of patients' personal goals. The aim of the present study was to investigate whether patients systematica...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：10.12740/PP/31505
更新日期：2015-03-01 00:00:00
abstract：:The aim of this study was evaluation of selected immune humoral indicators in connection with biochemical parameters of blood in 28 alcohol dependent men. Increased activity of liver enzymes: AspAT in 53,6% of patients, A1AT in 46,4%, GGTP in 25% were found. Macrocytosis in 29% of patients was observed. There were als...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：AIM:The aim of the present investigations was qualification of influence of loss of near and dear persons on cognitive functions in persons with Alzheimer's disease. METHOD:The initial population consisted of all the people who in the period from 1/02 to 30/10/2000 were treated at one of the following psychiatric trea...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：:Suicide is not only a medical but also a social problem. It seems important to be able to evaluate the risk of suicide in ordertointroduce appropriate preventive actions.Several instruments (scales) for the evaluation of the suicide risk may be of a help to the physician, however, they do not allow for a more precise ...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/PP/74161
更新日期：2018-02-28 00:00:00
abstract：INTRODUCTION:Electroconvulsive therapy (ECT) is the most effective treatment in a variety of psychiatric syndromes (especially mood disorders). However one of its adverse effects is neurocognitive dysfunction. Declarative memory impairment after ECT is unquestionable and well investigated. There are only few ambiguous ...
journal_title：Psychiatria polska
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2007-05-01 00:00:00
abstract：:Psychopathological picture of depression and the conduct of some hormone tests vs the therapeutic response to thymoleptics were examined. On the grounds of some diagnostic criteria, 84 patients with affective psychosis were divided into three diagnostic groups: unipolar (DJ, n = 54) and bipolar (DD, n = 20) endogenous...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Self-report methods are commonly applied in medicine and psychology. However, their diagnostic value in assessment of patients with acquired brain damage can be limited due to a number of various difficulties encountered by these patients, including cognitive disorders, fatigue, similarity of psychopathological and so...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2013-05-01 00:00:00
abstract：:The paper presents the objectives and design of an ongoing multicenter randomized, controlled trial EDEN (European Day Hospital EvaluatioN). The EDEN-study aims to evaluate the efficacy of acute psychiatric treatment in a day hospital setting in five European centres: Dresden, London, Michalovce, Prague and Wroclaw. T...
journal_title：Psychiatria polska
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-11-01 00:00:00
abstract：:Serum dopamine-beta-hydroxylase (DBH) activity was determined in the following diagnostic groups of patients (DSM-III-R criteria): panic disorder (n = 16), generalized anxiety disorder (n = 10), hypochondrical disorder (n = 16). Twenty healthy persons constituted the control group. Enzyme activity in the group of pani...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
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journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2005-07-01 00:00:00
abstract：:The purpose of this review is to give useful information to guide clinicians when treating pregnant women affected by bipolar disorder. This review focuses on mood stabilizers including lithium, sodium valproate, carbamazepine, oxcarbazepine, gabapentin, lamotrigine and topiramate. Data have been extracted from a MEDL...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：10.12740/pp/25834
更新日期：2014-09-01 00:00:00
abstract：AIM:Amphetamine and its derivates can induce, usually after many intoxications, schizophrenia-like psychosis. These disorders appeared only in part patients with amphetamine dependence. Aim of the study was to establish prevalence of selective risk factors of schizophrenia development in amphetamine users: 1) with amph...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2012-07-01 00:00:00
abstract：:Alcohol has been established as a teratogenic agent that in prenatal exposure can cause a variety of adverse pregnancy outcomes depending on dose, timing, and conditions of exposure. Although alcohol, like many other teratogenes, can cause alterations in morphology, growth, and neurobehavioral outcomes, this report fo...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：:The paper presents a review of recent data on research and clinical significance of gating of the P50 component of the auditory evoked potentials (AEP). Information filters are a necessary element for the proper functioning of the brain. It appears as though they have an important role in the information-transfer mech...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-09-01 00:00:00
abstract：AIM:The study was aimed at finding relationships between self-concept, alcohol expectancies and drinking in the group of high school students. It was expected that a higher level of alcohol consumption was related to lower self-concept and positive expectancies concerning alcohol use. METHOD:The group of 229 Polish hi...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
abstract：:Early intervention in psychotic disorders, particularly schizophrenia, has been increasingly recognized as important by clinicians. The benefits of early intervention in schizophrenia to patients include prevention of neurobiological changes, minimization of secondary morbidity and prevention of relapse. Other benefit...
journal_title：Psychiatria polska
pub_type： 杂志文章,评审
doi：
更新日期：2007-01-01 00:00:00
abstract：AIM:To assess cultural attitudes and beliefs among (female) patients being treated for various kinds of eating disorders in comparison with (female) patients diagnosed with depression and healthy girls. METHOD:Version II of the Cultural Questionnaire by M. Pilecki and B. Józefik referring to issues linked with those a...
journal_title：Psychiatria polska
pub_type： 杂志文章
doi：
更新日期：2012-03-01 00:00:00
