[Schizophrenia--neurodevelopmental and neurodegenerative theory revisited].

Abstract:

:The paper presents a critical review regarding the pathogenesis of schizophrenia. The neurodevelopmental theory which is now mostly recognized, needs some explanations, some elements of neurodegenerative theory are revisited. The developmental factors are confirmed as important in the pathogenesis of schizophrenia, but still it is unclear, how relatively subtle early damage causes so heavy thinking and emotional distortion like schizophrenia. There is also lack of evidence for neurodegeneration. Neuroimaging studies show the evidence for progression of brain abnormalities but at the same time there is no progression in neurocognitive disorders. Most likely late developmental disorders interfere with early brain damage, which leads to a neurocognitive disorder and clinical symptoms of schizophrenia.

journal_name

Psychiatr Pol

journal_title

Psychiatria polska

authors

Szulc A,Galińska B,Czernikiewicz A

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

249-58

issue

2

eissn

0033-2674

issn

2391-5854

journal_volume

39

pub_type

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