Four-dimensional imaging of murine subpleural alveoli using high-speed optical coherence tomography.

Abstract:

:The investigation of lung dynamics on alveolar scale is crucial for the understanding and treatment of lung diseases, such as acute lung injury and ventilator induced lung injury, and to promote the development of protective ventilation strategies. One approach to this is the establishment of numerical simulations of lung tissue mechanics where detailed knowledge about three-dimensional alveolar structure changes during the ventilation cycle is required. We suggest four-dimensional optical coherence tomography (OCT) imaging as a promising modality for visualizing the structural dynamics of single alveoli in subpleural lung tissue with high temporal resolution using a mouse model. A high-speed OCT setup based on Fourier domain mode locked laser technology facilitated the acquisition of alveolar structures without noticeable motion artifacts at a rate of 17 three-dimensional stacks per ventilation cycle. The four-dimensional information, acquired in one single ventilation cycle, allowed calculating the volume-pressure curve and the alveolar compliance for single alveoli.

journal_name

J Biophotonics

journal_title

Journal of biophotonics

authors

Kirsten L,Gaertner M,Schnabel C,Meissner S,Koch E

doi

10.1002/jbio.201200027

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

148-52

issue

2

eissn

1864-063X

issn

1864-0648

journal_volume

6

pub_type

杂志文章
  • Cross-polarization optical coherence tomography for early bladder-cancer detection: statistical study.

    abstract::The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolariz...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201000088

    authors: Gladkova N,Streltsova O,Zagaynova E,Kiseleva E,Gelikonov V,Gelikonov G,Karabut M,Yunusova K,Evdokimova O

    更新日期:2011-08-01 00:00:00

  • siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase.

    abstract::Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particl...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201700329

    authors: Rudnitzki F,Feineis S,Rahmanzadeh R,Endl E,Lutz J,Groll J,Hüttmann G

    更新日期:2018-09-01 00:00:00

  • Analysis of basidiomycete pigments in situ by Raman spectroscopy.

    abstract::Basidiomycetes, that is, mushroom-type fungi, are known to produce pigments in response to environmental impacts. As antioxidants with a high level of unsaturation, these compounds can neutralize highly oxidative species. In the event of close contact with other microbes, the enzymatically controlled pigment productio...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201700369

    authors: Tauber JP,Matthäus C,Lenz C,Hoffmeister D,Popp J

    更新日期:2018-06-01 00:00:00

  • Experimental study of the evanescent-wave photonic sensors response in presence of molecular beacon conformational changes.

    abstract::An experimental study of the influence of the conformational change suffered by molecular beacon (MB) probes-upon the biorecognition of nucleic acid target oligonucleotides over evanescent wave photonic sensors-is reported. To this end, high sensitivity photonic sensors based on silicon photonic bandgap (PBG) structur...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201800030

    authors: Ruiz-Tórtola Á,Prats-Quílez F,González-Lucas D,Bañuls MJ,Maquieira Á,Wheeler G,Dalmay T,Griol A,Hurtado J,Bohlmann H,Götzen R,García-Rupérez J

    更新日期:2018-10-01 00:00:00

  • Assesment of apoptosis induced changes in scattering using optical coherence tomography.

    abstract::The aim of this study is to identify changes in scattering with optical coherence tomography (OCT) and relate these measurements with mitochondrial changes during the initiation of apoptosis. Human retinal pigment epithelial cells were cultured and apoptosis was induced using 10% alcohol. Using the attenuation coeffic...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201500198

    authors: de Bruin DM,Broekgaarden M,van Gemert MJ,Heger M,de la Rosette JJ,Van Leeuwen TG,Faber DJ

    更新日期:2016-09-01 00:00:00

  • Label free optical sensor for Avidin based on single gold nanoparticles functionalized with aptamers.

    abstract::Optical spectroscopy of a single gold nanoparticle, functionalized with an aptamer, is used to sense the specific binding of avidin. Herewith, the field of single noble metal nanoparticle biosensors is extended to the important field of aptamer based assays. The sensitivity of this initial, but not yet optimized apta-...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.200910006

    authors: Hernandez FJ,Dondapati SK,Ozalp VC,Pinto A,O'Sullivan CK,Klar TA,Katakis I

    更新日期:2009-04-01 00:00:00

  • Monitoring caffeine and resveratrol cutaneous permeation by confocal Raman microspectroscopy.

    abstract::Dynamic follow-up of exogenous molecules permeation through the skin is one among many competing applications for confocal Raman microspectroscopy. Previous studies showed the feasibility of tracking actives through the skin; the next step should be recording in vivo kinetics. Thus, we conducted a study to evaluate th...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201300011

    authors: Tfaili S,Josse G,Angiboust JF,Manfait M,Piot O

    更新日期:2014-09-01 00:00:00

  • Optical investigations of the RNA polymerase molecular motor.

    abstract::Molecular motors have been extensively studied over the past 25 years using a range of optical microscopy methods. The specific example of RNA polymerase, responsible for transcribing the information encoded in DNA into RNA, illustrates the strength of the convergence between these recent approaches and the vast store...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.200810030

    authors: Strick TR

    更新日期:2008-09-01 00:00:00

  • Towards Raman spectroscopy of urine as screening tool.

    abstract::For the screening purposes urine is an especially attractive biofluid, since it offers easy and noninvasive sample collection and provides a snapshot of the whole metabolic status of the organism, which may change under different pathological conditions. Raman spectroscopy (RS) has the potential to monitor these chang...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201900143

    authors: Žukovskaja O,Ryabchykov O,Straßburger M,Heinekamp T,Brakhage AA,Hennings CJ,Hübner CA,Wegmann M,Cialla-May D,Bocklitz TW,Weber K,Popp J

    更新日期:2020-01-01 00:00:00

  • Nanofluidic devices towards single DNA molecule sequence mapping.

    abstract::Nanofluidics enables the imaging of stretched single molecules with potential applications for single molecule sequence mapping. Lab-on-a-chip devices for single cell trapping and lyzing, genomic DNA extraction from single cells, and optical mapping of genomic length DNA has been demonstrated separately. Yet the pursu...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章,评审

    doi:10.1002/jbio.201200050

    authors: Marie R,Kristensen A

    更新日期:2012-08-01 00:00:00

  • Application of corneal tomography before keratorefractive procedure for laser vision correction.

    abstract::Ectasia after refractive surgery represents a major concern among refractive surgeons. Corneal abnormalities and preexisting corneal ectasia are the most important risk factors. Corneal topography and central corneal thickness are the factors traditionally screening for in refractive surgery candidates. Study of the a...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201500236

    authors: Luz A,Lopes B,Salomão M,Ambrósio R

    更新日期:2016-05-01 00:00:00

  • Scattering based hyperspectral imaging of plasmonic nanoplate clusters towards biomedical applications.

    abstract::A new optical scattering contrast-agent based on polymer-nanoparticle encapsulated silver nanoplates (PESNs) is presented. Silver nanoplates were chosen due to the flexibility of tuning their plasmon frequencies. The polymer coating preserves their physical and optical properties and confers other advantages such as c...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201500177

    authors: Ray A,Kopelman R,Chon B,Briggman K,Hwang J

    更新日期:2016-07-01 00:00:00

  • Sparse-graph manifold learning method for bioluminescence tomography.

    abstract::In preclinical researches, bioluminescence tomography (BLT) has widely been used for tumor imaging and monitoring, imaged-guided tumor therapy, and so forth. For these biological applications, both tumor spatial location and morphology analysis are the leading problems needed to be taken into account. However, most ex...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201960218

    authors: Guo H,Gao L,Yu J,He X,Wang H,Zheng J,Yang X

    更新日期:2020-04-01 00:00:00

  • Dynamic imaging and quantification of subcellular motion with eigen-decomposition optical coherence tomography-based variance analysis.

    abstract::The dynamic properties of subcellular organism are important biomarkers of the health. Imaging subcellular level dynamics provides effective solutions for evaluating cell metabolism and testing the responses of cells to pathogens and drugs in pharmaceutical engineering. In this paper, we demonstrate an innovative appr...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201900076

    authors: Wei W,Tang P,Xie Z,Li Y,Wang RK

    更新日期:2019-10-01 00:00:00

  • Role of blood oxygenation saturation in ovarian cancer diagnosis using multi-spectral photoacoustic tomography.

    abstract::In photoacoustic tomography (PAT), a tunable laser typically illuminates the tissue at multiple wavelengths, and the received photoacoustic waves are used to form functional images of relative total haemoglobin (rHbT) and blood oxygenation saturation (%sO2 ). Due to measurement errors, the estimation of these paramete...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.202000368

    authors: Amidi E,Yang G,Uddin KMS,Luo H,Middleton W,Powell M,Siegel C,Zhu Q

    更新日期:2020-12-30 00:00:00

  • Longtime driving induced cerebral hemodynamic elevation and behavior degradation as assessed by functional near-infrared spectroscopy and a voluntary attention test.

    abstract::Drowsy driving contributes to ~20% of all traffic accidents worldwide. Onsite monitoring the mental condition of a driver and forewarning may be a preventive solution to reduce occurrence of drowsiness and potential accidents. Functional near-infrared spectroscopy (fNIRS) has been successfully utilized in hemodynamics...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201800160

    authors: Li T,Lin Y,Gao Y,Zhong F

    更新日期:2018-12-01 00:00:00

  • Fluorescence lifetime metabolic mapping of hypoxia-induced damage in pancreatic pseudo-islets.

    abstract::Pancreatic islet isolation from donor pancreases is an essential step for the transplantation of insulin-secreting β-cells as a therapy to treat type 1 diabetes mellitus. This process however damages islet basement membranes, which can lead to islet dysfunction or death. Posttransplantation, islets are further stresse...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.202000375

    authors: Zbinden A,Carvajal Berrio DA,Urbanczyk M,Layland SL,Bosch M,Fliri S,Lu CE,Jeyagaran A,Loskill P,Duffy GP,Schenke-Layland K

    更新日期:2020-12-01 00:00:00

  • A useful way to develop effective in vivo skin optical clearing agents.

    abstract::Skin optical clearing has shown tremendous potential in improving various optical imaging performances, but there is some certain blindness in screening out high-efficiency in vivo optical clearing methods. In this work, three optical clearing agents: sucrose (Suc), fructose (Fruc) and PEG-400 (PEG), and two chemical ...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201600221

    authors: Shi R,Guo L,Zhang C,Feng W,Li P,Ding Z,Zhu D

    更新日期:2017-06-01 00:00:00

  • Development of full-field optical spatial coherence tomography system for automated identification of malaria using the multilevel ensemble classifier.

    abstract::Malaria is a life-threatening infectious blood disease affecting humans and other animals caused by parasitic protozoans belonging to the Plasmodium type especially in developing countries. The gold standard method for the detection of malaria is through the microscopic method of chemically treated blood smears. We de...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201700279

    authors: Singla N,Srivastava V,Mehta DS

    更新日期:2018-05-01 00:00:00

  • Intracellular localization and delivery of plasmid DNA by biodegradable microsphere-mediated femtosecond laser optoporation.

    abstract::Micro-/nanosphere-mediated femtosecond laser cell perforation is one of the high throughput technologies used for macro-molecule-delivery into multiple cells. We have demonstrated the delivery of plasmid-DNA/liposome complexes into cells using biodegradable polymer microspheres and a femtosecond laser and investigated...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201600323

    authors: Ishii A,Hiruta Y,Heinemann D,Heisterkamp A,Kanazawa H,Terakawa M

    更新日期:2017-12-01 00:00:00

  • Joint tagging assisted fluctuation nanoscopy enables fast high-density super-resolution imaging.

    abstract::In fluctuation-based optical nanoscopy, investigating high-density labeled subcellular structures with high fidelity has been a significant challenge. In this study, based on super-resolution radial fluctuation (SRRF) microscopy, the joint tagging (JT) strategy is employed to enable fast high-density nanoscopic imagin...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201800020

    authors: Zeng Z,Ma J,Xi P,Xu C

    更新日期:2018-09-01 00:00:00

  • Antimicrobial activity of amphiphilic nanomicelles loaded with curcumin against Pseudomonas aeruginosa alone and activated by blue laser light.

    abstract::The aim of this work was to assess the antimicrobial efficacy on Pseudomonas aeruginosa of nanomicelles loaded with curcumin (CUR) alone and activated by blue laser light in an antimicrobial photodynamic therapy (APDT) approach. First, free CUR in liquid suspension and loaded in three amphiphilic nanomicelles (CUR-DAP...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.202000350

    authors: Rupel K,Zupin L,Brich S,Mardirossian M,Ottaviani G,Gobbo M,Di Lenarda R,Pricl S,Crovella S,Zacchigna S,Biasotto M

    更新日期:2020-11-05 00:00:00

  • Inverse SORS for detecting a low Raman-active turbid sample placed inside a highly Raman-active diffusely scattering matrix - A feasibility study.

    abstract::The broad range of applications of spatially-offset Raman spectroscopy (SORS) were found to involve samples having only marginal differences in Raman cross-sections between the surface and subsurface targets. We report the results of a feasibility study to evaluate the potential of the approach to identify the presenc...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201600075

    authors: Khan KM,Dutta SB,Krishna H,Majumder SK

    更新日期:2016-09-01 00:00:00

  • Automatic and label-free identification of blood vessels in gliomas using the combination of multiphoton microscopy and image analysis.

    abstract::Currently, the targeted treatment of tumor based on the tumor microenvironment is newly developed. Blood vessels are the key parts in the tumor microenvironment, which is taken as a new visible target for tumor therapy. Multiphoton microscopy (MPM), based on the second harmonic generation and two-photon excited fluore...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201900006

    authors: Fang N,Wu Z,Wang X,Kang D,Li L,Chen Y,Zheng X,Cai S,Liu X,Chen Z,Tu H,Lin Y,Chen J

    更新日期:2019-09-01 00:00:00

  • Modern trends in biophotonics for clinical diagnosis and therapy to solve unmet clinical needs.

    abstract::This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, t...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章,评审

    doi:10.1002/jbio.201600290

    authors: Krafft C

    更新日期:2016-12-01 00:00:00

  • Detecting hemodynamic changes in the foot vessels of diabetic patients by photoacoustic tomography.

    abstract::Limb perfusion monitoring is critical for diabetes mellitus (DM) patients as they are vulnerable to vascular complications due to prolonged hyperglycemia. However, current clinical approaches are ineffective in vascular imaging and in assessing vascular function in lower limbs. In this work, a concave ultrasound trans...

    journal_title:Journal of biophotonics

    pub_type: 信件

    doi:10.1002/jbio.202000011

    authors: Yang J,Zhang G,Shang Q,Wu M,Huang L,Jiang H

    更新日期:2020-08-01 00:00:00

  • Pseudo-real-time retinal layer segmentation for high-resolution adaptive optics optical coherence tomography.

    abstract::We present a pseudo-real-time retinal layer segmentation for high-resolution Sensorless Adaptive Optics-Optical Coherence Tomography (SAO-OCT). Our pseudo-real-time segmentation method is based on Dijkstra's algorithm that uses the intensity of pixels and the vertical gradient of the image to find the minimum cost in ...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.202000042

    authors: Janpongsri W,Huang J,Ng R,Wahl DJ,Sarunic MV,Jian Y

    更新日期:2020-08-01 00:00:00

  • Stain-free interferometric phase microscopy correlation with DNA fragmentation stain in human spermatozoa.

    abstract::Acridine orange (AO) staining is used to diagnose DNA fragmentation status in sperm cells. Interferometric phase microscopy (IPM) is an optical imaging method based on digital holographic microscopy that provides quantitative morphological and refractive index imaging of cells in vitro without the need for staining. W...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201800137

    authors: Barnea I,Karako L,Mirsky SK,Levi M,Balberg M,Shaked NT

    更新日期:2018-11-01 00:00:00

  • Prognostic analysis of amyotrophic lateral sclerosis based on clinical features and plasma surface-enhanced Raman spectroscopy.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a wide range of survival times. We aimed to explore prognostic factors related to short survival based on clinical features and plasma metabolic signatures using surface-enhanced Raman spectroscopy (SERS). One hundred and thirty-eight sporad...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201900012

    authors: Zhang QJ,Chen Y,Zou XH,Hu W,Lin XL,Feng SY,Chen F,Xu LQ,Chen WJ,Wang N

    更新日期:2019-08-01 00:00:00

  • Quantitative diagnosis of cervical neoplasia using fluorescence lifetime imaging on haematoxylin and eosin stained tissue sections.

    abstract::The use of conventional fluorescence microscopy for characterizing tissue pathological states is limited by overlapping spectra and the dependence on excitation power and fluorophore concentration. Fluorescence lifetime imaging microscopy (FLIM) can overcome these limitations due to its insensitivity to fluorophore co...

    journal_title:Journal of biophotonics

    pub_type: 杂志文章

    doi:10.1002/jbio.201200202

    authors: Gu J,Fu CY,Ng BK,Gulam Razul Ss,Lim SK

    更新日期:2014-07-01 00:00:00