Abstract:
:Limb perfusion monitoring is critical for diabetes mellitus (DM) patients as they are vulnerable to vascular complications due to prolonged hyperglycemia. However, current clinical approaches are ineffective in vascular imaging and in assessing vascular function in lower limbs. In this work, a concave ultrasound transducer array-based photoacoustic tomography (PAT) system was used to image the foot dorsal section of a subject, and a total of seven DM patients and seven healthy volunteers were enrolled in this study. Hemodynamic changes in foot vessels during vascular occlusion as well as oxygen saturation (SO2 ) in rest were analyzed for both groups. The results obtained showed that DM patients have a unique peripheral hemodynamic response to occlusion and a lower level SO2 , compared to that for healthy subjects. This suggests that PAT has the potential to detect vascular dysfunction in DM patients and to measure the effect of treatment.
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Yang J,Zhang G,Shang Q,Wu M,Huang L,Jiang Hdoi
10.1002/jbio.202000011subject
Has Abstractpub_date
2020-08-01 00:00:00pages
e202000011issue
8eissn
1864-063Xissn
1864-0648journal_volume
13pub_type
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