Abstract:
:In preclinical researches, bioluminescence tomography (BLT) has widely been used for tumor imaging and monitoring, imaged-guided tumor therapy, and so forth. For these biological applications, both tumor spatial location and morphology analysis are the leading problems needed to be taken into account. However, most existing BLT reconstruction methods were proposed for some specific applications with a focus on sparse representation or morphology recovery, respectively. How to design a versatile algorithm that can simultaneously deal with both aspects remains an impending problem. In this study, a Sparse-Graph Manifold Learning (SGML) method was proposed to balance the source sparseness and morphology, by integrating non-convex sparsity constraint and dynamic Laplacian graph model. Furthermore, based on the nonconvex optimization theory and some iterative approximation, we proposed a novel iteratively reweighted soft thresholding algorithm (IRSTA) to solve the SGML model. Numerical simulations and in vivo experiments result demonstrated that the proposed SGML method performed much superior to the comparative methods in spatial localization and tumor morphology recovery for various source settings. It is believed that the SGML method can be applied to the related optical tomography and facilitate the development of optical molecular tomography.
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Guo H,Gao L,Yu J,He X,Wang H,Zheng J,Yang Xdoi
10.1002/jbio.201960218subject
Has Abstractpub_date
2020-04-01 00:00:00pages
e201960218issue
4eissn
1864-063Xissn
1864-0648journal_volume
13pub_type
杂志文章abstract::Spahr et al. recently commented on our latest paper "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" with a conclusion that the measured retinal pulse wave velocity (rPWV) in our paper was contradictory to theoretical predictions and previously published results. However, th...
journal_title:Journal of biophotonics
pub_type: 评论,杂志文章
doi:10.1002/jbio.201700379
更新日期:2018-02-01 00:00:00
abstract::We have developed a reflection-mode switchable subwavelength Bessel-beam (BB) and Gaussian-beam (GB) photoacoustic microscopy (PAM) system. To achieve both reflection-mode and high resolution, we tightly attached a very small ultrasound transducer to an optical objective lens with numerical aperture of 1.0 and working...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800215
更新日期:2019-02-01 00:00:00
abstract::Single-molecule localisation based super-resolution fluorescence imaging produces maps of the coordinates of fluorescent molecules in a region of interest. Cluster analysis algorithms provide information concerning the clustering characteristics of these molecules, often through the generation of cluster heat maps bas...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201400127
更新日期:2015-11-01 00:00:00
abstract::Limb perfusion monitoring is critical for diabetes mellitus (DM) patients as they are vulnerable to vascular complications due to prolonged hyperglycemia. However, current clinical approaches are ineffective in vascular imaging and in assessing vascular function in lower limbs. In this work, a concave ultrasound trans...
journal_title:Journal of biophotonics
pub_type: 信件
doi:10.1002/jbio.202000011
更新日期:2020-08-01 00:00:00
abstract::Whole slide imaging (WSI) has moved digital pathology closer to diagnostic practice in recent years. Due to the inherent tissue topography variability, accurate autofocusing remains a critical challenge for WSI and automated microscopy systems. The traditional focus map surveying method is limited in its ability to ac...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.202000227
更新日期:2020-12-01 00:00:00
abstract::Alveolar type II (ATII) cells in the peripheral human lung spontaneously differentiate toward ATI cells, thus enabling air-blood barrier formation. Here, linear Raman and coherent anti-Stokes Raman scattering (CARS) microscopy are applied to study cell differentiation of freshly isolated ATII cells. The Raman spectra ...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201800052
更新日期:2019-06-01 00:00:00
abstract::Photobiomodulation (PBM) therapy has been noted to promote cell proliferation and growth in many different cell types shown both in vitro and in vivo. Currently, treatment regimens are used in the clinic for a variety of ailments, including wound healing. However, most protocols treat an anatomical site without consid...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600025
更新日期:2016-12-01 00:00:00
abstract::A robust method is presented for evaluating the diffusion properties of chemicals in ex vivo biological tissues. Using this method that relies only on thickness and collimated transmittance measurements, the diffusion properties of glycerol, fructose, polypropylene glycol and water in muscle tissues were evaluated. Am...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800333
更新日期:2019-04-01 00:00:00
abstract::This study presents numerical simulations of UVC light propagation through seven different filtered face respirators (FFR) to determine their suitability for Ultraviolet germicidal inactivation (UVGI). UV propagation was modeled using the FullMonte program for two external light illuminations. The optical properties o...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000232
更新日期:2020-12-01 00:00:00
abstract::The paper presents a new algorithm based on some selected automatic quantitative methods for analysing thermal images. It shows the practical implementation of these image analysis methods in Matlab. It enables to perform fully automated and reproducible measurements of selected parameters in thermal images. The paper...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201500224
更新日期:2016-05-01 00:00:00
abstract::Low-power laser irradiation (LPLI) has been extensively employed to modulate inflammation in vitro and in vivo. Previous reports from our group indicated that LPLI might regulate glycemia in diabetic animals. Diabetes results in chronic hyperglycemia and therefore chronic inflammation by upregulation of inflammatory m...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600175
更新日期:2016-12-01 00:00:00
abstract::We investigate the optical wavelength dependence in quantitative photoacoustic (QPA) assessment of red blood cell (RBC) aggregation and oxygen saturation (sO2 ) during pulsatile blood flow. Experimentally, the pulsatile flow was imaged with a 700 to 900 nm laser using the VevoLAZR. Theoretically, the photoacoustic (PA...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700300
更新日期:2018-08-01 00:00:00
abstract::Solar radiation exposure is recognised to be a significant contributor to the development of skin cancer. Monitoring the simultaneous and consecutive mechanisms of interaction could provide a greater understanding of the process of photocarcinogenesis. This work presents an analysis of the biochemical and morphologica...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000337
更新日期:2020-10-24 00:00:00
abstract::The purpose of this study was to evaluate the tomographic features of postrefractive surgery eyes. This was a retrospective evaluation of clinical data. Three patients with post-LASIK (laser-assisted in situ keratomileusis) and two patients with post-SMILE (small incision lenticule extraction) ectasia were imaged with...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800253
更新日期:2019-02-01 00:00:00
abstract::Therapeutically exploiting vascular and metabolic endpoints becomes critical to translational cancer studies because altered vascularity and deregulated metabolism are two important cancer hallmarks. The metabolic and vascular phenotypes of three sibling breast tumor lines with different metastatic potential are inves...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800372
更新日期:2019-04-01 00:00:00
abstract::The aim of this study was to evaluate whether OCT topography of the Bowman's layer and artificial intelligence (AI) can result in better diagnosis of forme fruste (FFKC) and clinical keratoconus (KC). Normal (n = 221), FFKC (n = 72) and KC (n = 116) corneas were included. Some of the FFKC and KC patients had the fello...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900126
更新日期:2019-10-01 00:00:00
abstract::Uncoated and poly(styrene sulphonate) (PSS)-coated gold nanorods were taken up by NG108-15 neuronal cells. Exposure to 780 nm laser light at the plasmon resonance wavelength of the gold nanorods was found to induce intracellular Ca(2+) transients. The higher Ca(2+) peaks were observed at lower laser doses, with the hi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300043
更新日期:2014-10-01 00:00:00
abstract::Micro-/nanosphere-mediated femtosecond laser cell perforation is one of the high throughput technologies used for macro-molecule-delivery into multiple cells. We have demonstrated the delivery of plasmid-DNA/liposome complexes into cells using biodegradable polymer microspheres and a femtosecond laser and investigated...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600323
更新日期:2017-12-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a wide range of survival times. We aimed to explore prognostic factors related to short survival based on clinical features and plasma metabolic signatures using surface-enhanced Raman spectroscopy (SERS). One hundred and thirty-eight sporad...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900012
更新日期:2019-08-01 00:00:00
abstract::The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolariz...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201000088
更新日期:2011-08-01 00:00:00
abstract::The sun protection factor (SPF) values are currently determined using an invasive procedure, in which the volunteers are irradiated with ultraviolet (UV) light. Non-invasive approaches based on hybrid diffuse reflectance spectroscopy (HDRS) have shown a good correlation with conventional SPF testing. Here, we present ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000348
更新日期:2020-10-06 00:00:00
abstract::This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, t...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201600290
更新日期:2016-12-01 00:00:00
abstract::Molecular motors have been extensively studied over the past 25 years using a range of optical microscopy methods. The specific example of RNA polymerase, responsible for transcribing the information encoded in DNA into RNA, illustrates the strength of the convergence between these recent approaches and the vast store...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.200810030
更新日期:2008-09-01 00:00:00
abstract::Surface-enhanced Raman scattering (SERS) spectroscopy possesses the most promising advantage of multiplex detection for biosensing applications, which is achieved due to the narrow 'fingerprint' Raman spectra from the analyte molecules. We developed an ultrasensitive platform for the multiplex detection of cancer biom...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300084
更新日期:2014-11-01 00:00:00
abstract::Cardiomyocytes derived from human pluripotent stem cells are a promising tool for disease modeling, drug compound testing, and cardiac toxicity screening. Bio-image segmentation is a prerequisite step in cardiomyocyte image analysis by digital holography (DH) in microscopic configuration and has provided satisfactory ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800116
更新日期:2018-12-01 00:00:00
abstract::Cerebral malaria (CM) is a severe complication of Plasmodium falciparum infection associated with impaired cerebral blood flow. Visualization of the eye vasculature, which is embryologically derived from that of the brain, is used clinically to diagnose the syndrome. Here, we introduce camera-phone laser speckle imagi...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800098
更新日期:2019-01-01 00:00:00
abstract::High-resolution deformation measurements in a functionally graded hard tissue such as human dentin are essential to understand the unbound water-loss mediated changes and their role in its mechanical integrity. Yet a whole-field, 3-dimensional (3D) measurement and characterization of fully hydrated dentin in both macr...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700368
更新日期:2018-09-01 00:00:00
abstract::Several studies have demonstrated the potential of cross-polarization optical coherence tomography (CP-OCT) to quantify the severity of early caries lesions (tooth decay) on tooth surfaces. The purpose of this study is to show that 2D images of the lesion depth and the integrated reflectivity can be used to accurately...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201300137
更新日期:2015-01-01 00:00:00
abstract::Semiconductor nanoparticles (NPs) became important and wide-used tool for cell imaging because of their unique remarkable properties. Nevertheless, all previous investigations in this area were done on proliferating cells. For the first time, this work demonstrates strong influence of cell active proliferation/contact...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200066
更新日期:2013-03-01 00:00:00
abstract::Mucosal lesions of the upper aerodigestive tract usually concern the squamous epithelium of the surface. Many precancerous alterations now designated as potentially malignant are caused by DNA damage resulting from long term exposure to tobacco and alcohol consumption. The distinction from conditions with a similar ph...
journal_title:Journal of biophotonics
pub_type: 杂志文章,评审
doi:10.1002/jbio.201100085
更新日期:2012-04-01 00:00:00