Effects of Apelin on Left Ventricular-Arterial Coupling and Mechanical Efficiency in Rats with Ischemic Heart Failure.

abstract：Background:It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods:PubMed, Scopus, Web of Science, Chinese Nati...

journal_title：Disease markers

authors： Sun X,Zhou X,Zhang Y,Zhu X,Liu H

更新日期：2018-05-15 00:00:00

abstract：BACKGROUND:Tissue Polypeptide Specific antigen has recently been proposed as diagnostic marker of apoptosis in NonAlcoholic SteatoHepatitis. The aim of this study was to validate in patients suffering from NonAlcoholic SteatoHepatitis the clinical utility of this marker after different programs of weight reduction. ME...

journal_title：Disease markers

authors： Tarantino G,Mazzarella C,Tarantino M,Di Minno MN,Conca P

更新日期：2009-01-01 00:00:00

abstract：Background and Objective:Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, ...

journal_title：Disease markers

authors： Brito-Mendoza L,Bologna-Molina R,Irigoyen-Camacho ME,Martinez G,Sánchez-Romero C,Mosqueda-Taylor A

更新日期：2018-07-29 00:00:00

abstract：:Exposure to asbestos is the main cause of malignant pleural mesothelioma (MPM), a highly aggressive cancer of the pleura. Since the only tools for early detection are based on radiological tests, some authors focused on serum markers (i.e., mesothelin). The aim of this study was the evaluation of new serum biomarkers ...

journal_title：Disease markers

authors： Bonotti A,Foddis R,Landi S,Melaiu O,De Santi C,Giusti L,Donadio E,Ciregia F,Mazzoni MR,Lucacchini A,Bovenzi M,Comar M,Pantani E,Pistelli A,Cristaudo A

更新日期：2017-01-01 00:00:00

abstract：:Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...

journal_title：Disease markers

authors： Keller MD,Kanter EM,Lieber CA,Majumder SK,Hutchings J,Ellis DL,Beaven RB,Stone N,Mahadevan-Jansen A

更新日期：2008-01-01 00:00:00

abstract：:Current problems in obtaining suitable monoclonal antibodies (MoAbs) for in vivo imaging and therapy can now be bypassed using protein-engineering rather than conventional hybridoma technology. Rodent antibody binding sites can be grafted onto human acceptor antibodies thus reshaping the human MoAbs into reagents with...

journal_title：Disease markers

authors： Verhoeyen ME,Saunders JA,Broderick EL,Eida SJ,Badley RA

更新日期：1991-05-01 00:00:00

abstract：:Nonenzymatic glycosylation or glycation of macromolecules, especially proteins leading to their oxidation, play an important role in diseases. Glycation of proteins primarily results in the formation of an early stage and stable Amadori-lysine product which undergo further irreversible chemical reactions to form advan...

journal_title：Disease markers

authors： Ansari NA,Moinuddin,Ali R

更新日期：2011-01-01 00:00:00

abstract：:In view of the potential uses of cell surface tumour associated antigens in novel anticancer treatment, a study was designed to investigate whether the biological response modifiers interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) could effect the expression of an epitope on the tumour associa...

journal_title：Disease markers

authors： Clark S,McGuckin MA,Hurst T,Ward BG

更新日期：1994-10-01 00:00:00

abstract：:S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...

journal_title：Disease markers

authors： Paul E,Cochran AJ

更新日期：1988-10-01 00:00:00

abstract：:Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes. In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins...

journal_title：Disease markers

authors： Gornik O,Lauc G

更新日期：2008-01-01 00:00:00

abstract：:Chronic infection with the hepatitis B virus (HBV) is a known risk factor in the development of human hepatocellular carcinoma (HCC). The HBV-encoded X protein, HBx, has been investigated for properties that may explain its cancer cofactor role in transgenic mouse lines. We discuss here recent data showing that HBx is...

journal_title：Disease markers

authors： Madden CR,Slagle BL

更新日期：2001-01-01 00:00:00

abstract：:Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...

journal_title：Disease markers

authors： Mieczkowska J,Rutkowska E,Mosiewicz J,Mosiewicz B

更新日期：2016-01-01 00:00:00

abstract：:Involvement of the ets-1 proto-oncogene located at chromosome band 11q23 was studied in six tumors and in a congenital chromosome abnormality affecting the 11q23 region, in order to determine whether the breakpoint of these rearrangements was identical at the molecular level. In multiple restriction digestions a 5.4 k...

journal_title：Disease markers

authors： Koduru PR,Offit K,Jhanwar SC

更新日期：1989-07-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. Obesity is the most common and well-established risk factor for NAFLD, but there are large interindividual differences in the relationship between weight status and the development of NAFLD. Beta-3-adrenergic receptor (ADRB3)...

journal_title：Disease markers

authors： Sakamoto Y,Oniki K,Kumagae N,Morita K,Otake K,Ogata Y,Saruwatari J

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:Cardiac troponin levels have been reported to add value in the detection of cardiovascular complications in noncardiac surgery. A sensitive cardiac troponin I (cTnI) assay could provide more accurate prognostic information. METHODS:This study prospectively enrolled 142 patients with at least one Revised Car...

journal_title：Disease markers

authors： Borges FK,Furtado MV,Rossini AP,Bertoluci C,Gonzalez VL,Bertoldi EG,Pezzali LG,Machado DL,Grutcki DM,Rech LG,Magalhães M,Polanczyk CA

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND AND AIM:Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic pep...

journal_title：Disease markers

authors： Lee SJ,Lee DG,Lim DS,Hong S,Park JS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Echocardiographic evaluation of left ventricular (LV) structural and functional alterations in hypertension has some limitations, potentially overcome by using biomarkers. ST2, a prognostic biomarker for heart failure and myocardial infarction patients, was less studied in hypertension. AIM:To analyze the r...

journal_title：Disease markers

authors： Farcaş AD,Anton FP,Goidescu CM,Gavrilă IL,Vida-Simiti LA,Stoia MA

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to evaluate the combined effects of MMP-2 and TIMP-2 protein immunoreactivities on the prognosis in endometrial carcinoma. METHODS:Paraffin-embedded tissue samples from 225 primary endometrioid adenocarcinomas and 13 histologies other than endometrioid adenocarcinoma were immunohist...

journal_title：Disease markers

authors： Honkavuori-Toivola M,Santala M,Soini Y,Turpeenniemi-Hujanen T,Talvensaari-Mattila A

更新日期：2013-01-01 00:00:00

abstract：Background:Few previous studies have comprehensively explored the level of DNA methylation and gene expression in ccRCC. The purpose of this study was to identify the key clear cell renal cell carcinoma- (ccRCC-) related DNA methylation-driven genes (MDG) and to build a prognostic model based on the level of DNA methyl...

journal_title：Disease markers

authors： Hu M,Xie J,Hou H,Liu M,Wang J

更新日期：2020-07-11 00:00:00

abstract：:Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...

journal_title：Disease markers

authors： Yokoyama M,Watanabe T,Otaki Y,Takahashi H,Arimoto T,Shishido T,Miyamoto T,Konta T,Shibata Y,Daimon M,Ueno Y,Kato T,Kayama T,Kubota I

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:This study was undertaken to investigate the OPG profiles in gingival crevicular fluid (GCF), saliva, and gingival tissues of chronic periodontitis (CP) patients in response to open flap debridement (OFD). SUBJECTS AND METHODS:The study included 30 subjects divided into 2 groups: 20 CP patients and 10 perio...

journal_title：Disease markers

authors： Hassan SH,El-Refai MI,Ghallab NA,Kasem RF,Shaker OG

更新日期：2015-01-01 00:00:00

abstract：Background:Obese women with gestational diabetes mellitus (GDM) have a higher risk of adverse outcomes than women with obesity or GDM alone. Our study is aimed at investigating the discriminatory power of circulatory Wnt1-inducible signaling pathway protein-1 (WISP1), a novel adipocytokine, on the copresence of prepreg...

journal_title：Disease markers

authors： Liu L,Hu J,Yang L,Wang N,Liu Y,Wei X,Gao M,Wang Y,Ma Y,Wen D

更新日期：2020-04-14 00:00:00

abstract：:Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patient...

journal_title：Disease markers

authors： Kitahara K,Kawa S,Katsuyama Y,Umemura T,Ozaki Y,Takayama M,Arakura N,Ota M

更新日期：2008-01-01 00:00:00

abstract：:Changes of glycosylation pattern in serum proteins have been linked to various diseases including cancer, suggesting possible development of novel biomarkers based on the glycomic analysis. In this study, N-linked glycans from human serum were quantitatively profiled by matrix-assisted laser desorption ionization time...

journal_title：Disease markers

authors： Kim JH,Park CW,Um D,Baek KH,Jo Y,An H,Kim Y,Kim TJ

更新日期：2014-01-01 00:00:00

abstract：Objective:In order to further study the changes of cerebral functional connectivity in patients with toothache (TA), this study used the resting-state functional magnetic resonance imaging (rs-fMRI) technique and degree centrality (DC) analysis method. Methods:Eighteen TA patients (8 males, 10 females) and 18 healthy ...

journal_title：Disease markers

authors： Wu SN,Zhang MY,Shu HY,Liang RB,Ge QM,Pan YC,Zhang LJ,Li QY,Shao Y

更新日期：2020-12-28 00:00:00

abstract：:Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on se...

journal_title：Disease markers

authors： Zampieri BL,Biselli JM,Goloni-Bertollo EM,Vannucchi H,Carvalho VM,Cordeiro JA,Pavarino EC

更新日期：2012-01-01 00:00:00

abstract：:Clinical variables contribute to the severity of Kashin-Beck disease (KBD). However, it is unclear if there is a correlation between gene expression and clinical variables. Peripheral blood samples were collected from 100 patients with KBD and 100 healthy controls from KBD-endemic areas to identify differentially expr...

journal_title：Disease markers

authors： Wang X,Ning Y,Zhang P,Yang L,Li C,Zhou R,Guo X

更新日期：2019-01-03 00:00:00

abstract：:The nonspecific inflammatory bowel diseases (IBD) represent a heterogeneous group of chronic inflammatory disorders of the gastrointestinal tract, and Leśniowski-Crohn's disease (CD) and ulcerative colitis (UC) are among the two major clinical forms. Despite the great progress in understanding the pathogenesis of thes...

journal_title：Disease markers

authors： Derkacz A,Olczyk P,Komosinska-Vassev K

更新日期：2018-06-11 00:00:00

abstract：UNLABELLED:Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis. To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in cell division with clinical outcome, we consecutively...

journal_title：Disease markers

authors： Grossi F,Dal Bello MG,Salvi S,Puzone R,Pfeffer U,Fontana V,Alama A,Rijavec E,Barletta G,Genova C,Sini C,Ratto GB,Taviani M,Truini M,Merlo DF

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To eval...

journal_title：Disease markers

authors： Fan Z,Pan J,Zhang Y,Wang Z,Zhu M,Yang B,Shi L,Jing H

更新日期：2015-01-01 00:00:00