Abstract:
OBJECTIVE:The aim of this study was to evaluate the combined effects of MMP-2 and TIMP-2 protein immunoreactivities on the prognosis in endometrial carcinoma. METHODS:Paraffin-embedded tissue samples from 225 primary endometrioid adenocarcinomas and 13 histologies other than endometrioid adenocarcinoma were immunohistochemically stained for MMP-2 and TIMP-2. RESULTS:In Kaplan-Meier analysis, the 5-year cancer-specific survival rate of the endometrioid adenocarcinoma patients with negative MMP-2 and positive TIMP-2 staining was 100%, whereas only 78% of patients presenting with positive MMP-2 and negative TIMP-2 staining results were alive at that time. In Cox regression analysis, patients with positive MMP-2 and negative TIMP-2 immunostaining had a 4.7-fold relative risk of death from endometrial carcinoma compared to the group of patients with negative MMP-2 and positive or negative TIMP-2 immunoreaction. CONCLUSIONS:MMP-2 seems to be the main metalloproteinase determining the prognosis in endometrial carcinoma. Combination of strong MMP-2 and weak TIMP-2 immunostainings was the most potent prognostic marker for poor survival.
journal_name
Dis Markersjournal_title
Disease markersauthors
Honkavuori-Toivola M,Santala M,Soini Y,Turpeenniemi-Hujanen T,Talvensaari-Mattila Adoi
10.1155/2013/416870subject
Has Abstractpub_date
2013-01-01 00:00:00pages
261-6issue
4eissn
0278-0240issn
1875-8630journal_volume
35pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract:OBJECTIVE:To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a relationship exists between the cTn level and the likelihood of Type I MI. BACKGROUND:In the ED, cTn is u...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/157812
更新日期:2015-01-01 00:00:00
abstract::Microtubule-associated protein 4 (MAP4) plays an important role in microtubule assembly and stabilization. The purpose of this study was to investigate the level of expression of MAP4 in lung adenocarcinoma (LADC) samples and to evaluate its prognostic value and the influence on cancer progression in LADC patients. Th...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/8956072
更新日期:2018-03-18 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide due to latent liver disease, late diagnosis, and nonresponse to systemic treatments. Till now, surgical and/or biopsy specimens are still generally used as a gold standard by the clinicians for clinical decision-making. Howeve...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2016/1427849
更新日期:2016-01-01 00:00:00
abstract:Background:The systemic immune-inflammation index (SII), based on peripheral lymphocytes, neutrophils, and platelet count, has been used as a prognostic marker for several tumors. However, use of the SII has not been reported for gastric cancer. Methods:We evaluated the prognostic value of the SII in primary and valid...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/1787424
更新日期:2018-12-02 00:00:00
abstract:INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0716
更新日期:2010-01-01 00:00:00
abstract::Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/4857917
更新日期:2016-01-01 00:00:00
abstract::Plasma from bronchial asthma patients and healthy controls was investigated for the content of lipoxygenase products. After lipid extraction using SEP-PAK C18 Cartridges, the lipoxygenase products were measured by Enzyme-Immunoassay. Elevated chemotactic B4 was found in plasma from asthmatic patients with mean value (...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/1994/121453
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre-analytical and biologic variability are few. METHODS:VEGF was measured by ELISA methods in serum and plasma from healthy persons and RA patients. Pre-analytical factors were...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/707864
更新日期:2008-01-01 00:00:00
abstract:Purpose:To investigate the expression profiles of long noncoding RNAs (lncRNAs) in patients with atrial fibrillation (AF). Methods:The peripheral blood monocytes of a total of 20 patients with AF and 20 healthy subjects were collected for gene chip technology to detect differentially expressed lncRNAs from 2017.01 to ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8872142
更新日期:2020-11-22 00:00:00
abstract::This study was undertaken to assess the biochemical changes induced in chronic schistosomiasis and/or chronic HCV, as well as to pinpoint the most significant parameters which could be used as dependable indices for the differentiation of single and coupled infections with or without liver cirrhosis. The selected pati...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2000/732754
更新日期:2000-01-01 00:00:00
abstract:Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/4310790
更新日期:2018-09-27 00:00:00
abstract:BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/285906
更新日期:2014-01-01 00:00:00
abstract::Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/9612421
更新日期:2016-01-01 00:00:00
abstract::Immunological and immunogenetic investigations are described in a group of 28 women with a history of unexplained recurrent (greater than or equal to 3 consecutive) spontaneous abortions (RSA). Compared with female blood donor controls, recurrent aborters had significantly elevated mean serum complement C4 (p less tha...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract::The present study evaluated diurnal variations and day-to-day fluctuations of salivary oxidative stress (OS) markers in healthy adult individuals. Whole unstimulated saliva was collected at 2 time intervals over 3 consecutive days. Glutathione peroxidase (GPX), superoxide dismutase (SOD), total antioxidant capacity (T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2017/2697464
更新日期:2017-01-01 00:00:00
abstract::The discovery that PSA exists in serum in both free and complexed forms led to development of immunoassays specific for different PSA forms. This helped in measuring free PSA in the presence of PSA-ACT (PSA-alpha antichymotrypsin), hence it was possible to calculate the percent free PSA or free to total PSA ratio, mea...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2004/913870
更新日期:2003-01-01 00:00:00
abstract::The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands dig...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/818570
更新日期:2015-01-01 00:00:00
abstract:Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9529053
更新日期:2019-10-10 00:00:00
abstract:Background:Determination of neonate serum's N-acetyl-β-hexosaminidase (HEX) activity and correlation results with Apgar scale and factors routinely determined in newborn serum. Aims:Providing reference values of neonates serum HEX activities, and indicate their diagnostic significance. Study design:The study was perf...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/6187245
更新日期:2018-07-02 00:00:00
abstract::This report describes the production and characterization of two new monoclonal antibodies (MoAb), WM-53 and WM-54, reacting with a human myeloid differentiation antigen, which has recently been assigned by the Third International Leucocyte Workshop on Human Differentiation Antigens into cluster CD-33 ('gp67'). To dat...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1987-12-01 00:00:00
abstract::Primary biliary cirrhosis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology, characterized by injury of the intrahepatic bile ducts that may eventually lead to cirrhosis and liver failure. Evidence suggests cardinal roles for both environmental factors and genetic susceptibilit...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.3233/DMA-2010-0747
更新日期:2010-01-01 00:00:00
abstract:Background:It is reported that miRNAs are aberrantly expressed in patients with pancreatic cancer. However, the diagnostic value of miRNAs in pancreatic cancer remains controversial. The meta-analysis was to access diagnostic accuracy of miRNAs in pancreatic cancer. Methods:PubMed, Scopus, Web of Science, Chinese Nati...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/6292396
更新日期:2018-05-15 00:00:00
abstract:Aim:To evaluate the diagnosis value of serum human epididymis protein 4 (HE4), cancer antigen 125 (CA125), the Risk of Ovarian Malignancy Algorithm (ROMA), and Copenhagen Index (CPH-I) at early stages for differentiating borderline ovarian tumors from epithelial ovarian cancer. Methods:We recruited 144 borderline ovar...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/6241743
更新日期:2019-10-13 00:00:00
abstract::MicroRNAs (miRNAs) are a class of small, non-coding RNA molecules that can regulate gene expression, thereby affecting crucial processes in cancer development. miRNAs offer great potential as biomarkers for cancer detection because of their remarkable stability in blood and their characteristic expression in different...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-120957
更新日期:2013-01-01 00:00:00
abstract::A major subtype of childhood lymphoblastic leukemia has been previously defined on the basis of expression of a cell surface marker referred to as the common acute lymphoblastic leukemia antigen. In this study we provide evidence that leukemic cells from most of the patients with common acute lymphoblastic leukemia co...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::In order to verify the role of CEA in the differential diagnosis of pancreatic cancer and to evaluate some influencing factors like age, tumor spread and liver dysfunction, this antigen was measured in the sera of 60 control subjects, 45 patients with pancreatic cancer, 37 with chronic pancreatitis, 67 with benign, an...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract:Objective:This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods:A cross-sectional study including 180 type 2 diabetic participants was conducted...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/3793768
更新日期:2018-04-16 00:00:00
abstract:BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2012/842764
更新日期:2012-01-01 00:00:00
abstract::In order to develop reagents that can detect the exposed core carbohydrate antigens of mucins, we have prepared monoclonal antibodies against partially deglycosylated LS174T human colon cancer mucin. The three monoclonal antibodies, 10F4, 15D3a, and 91S8, stained cancers of the colon, pancreas, stomach, breast, prosta...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1992-03-01 00:00:00