Abstract:
:Immunological and immunogenetic investigations are described in a group of 28 women with a history of unexplained recurrent (greater than or equal to 3 consecutive) spontaneous abortions (RSA). Compared with female blood donor controls, recurrent aborters had significantly elevated mean serum complement C4 (p less than 0.05), but not C3, levels. Immunoglobulin levels and T4:T8 ratios showed a similar distribution to the controls. Mixed lymphocyte reactivities to partners' lymphocytes were low in some of the patients, but hyporesponsiveness correlated well with husband-wife HLA-DR compatibility. No individual HLA specificity was significantly increased in the RSA patients, but the combination A3, B7, DR2 was common (p less than 0.02), and general HLA antigen sharing with partners was significantly increased (p less than 0.004) relative to obstetrically normal couples. RSA women who shared two or more HLA antigens with spouses had higher mean serum immunoglobulin concentrations, which for IgM reached statistical significance (p less than 0.05).
journal_name
Dis Markersjournal_title
Disease markersauthors
Kilpatrick DC,Liston WA,Neill G,Maxwell Csubject
Has Abstractpub_date
1989-04-01 00:00:00pages
87-94issue
2eissn
0278-0240issn
1875-8630journal_volume
7pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::Because tandem mass spectrometry- (MS/MS-) based newborn screening identifies many suspicious cases of fatty acid oxidation and carnitine cycle disorders, a simple, noninvasive test is required to confirm the diagnosis. We have developed a novel method to evaluate the metabolic defects in peripheral blood mononuclear ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/2984747
更新日期:2019-02-07 00:00:00
abstract::Alcohol abuse is one of the most common risk factor for chronic pancreatitis, but the underlying pathophysiological mechanisms remain unclear. The aim of this study was to identify genes that contribute to susceptibility or resistance for alcoholic chronic pancreatitis by screening the whole genome. Sixty-five patient...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/426764
更新日期:2008-01-01 00:00:00
abstract::Studies have shown that the maternal risk for Down syndrome (DS) may be modulated by alterations in folate metabolism. The aim of this study was to evaluate the influence of 12 genetic polymorphisms involved in folate metabolism on maternal risk for DS. In addition, we evaluated the impact of these polymorphisms on se...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2011-0869
更新日期:2012-01-01 00:00:00
abstract::We first investigated the difference in microRNA expression between normal NP cells and degenerative NP cells using gene chip. We have found that the expression of ERK1/2 was decreased with overexpression of miR-155 in normal nucleus pulposus cell. Expression of ERK1/2 was increased with inhibition of miR-155. Overexp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/6984270
更新日期:2016-01-01 00:00:00
abstract::To identify the novel, noninvasive biomarkers to assess the outcome and prognosis of breast cancer (BC), patients with high sensitivity and specificity are greatly desired. Herein, the miRNA expression profile and matched clinical features of BC patients were extracted from The Cancer Genome Atlas (TCGA) database. The...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3815952
更新日期:2019-12-30 00:00:00
abstract::Purpose. The aim of this study was to evaluate the sensitivity of pleural C-reactive protein (CRP) biomarker levels in identifying parapneumonic effusions. Methods. A single-center, retrospective review of 244 patients diagnosed with pleural effusions was initiated among patients at the Rabin Medical Center, Petah Tik...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7539780
更新日期:2016-01-01 00:00:00
abstract:Background:The role of miR-200c in gastric cancer remains controversial. This study is aimed at clarifying the diagnostic and prognostic value of miR-200c in gastric cancer through a meta-analysis. Methods:A comprehensive literature search of PubMed, Embase, and Ovid library databases was conducted. The studies includ...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2019/8949618
更新日期:2019-04-04 00:00:00
abstract::Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/2032679
更新日期:2020-07-08 00:00:00
abstract:Background:Breast cancer is the commonest malignancy in women worldwide. It is estimated to affect approximately 1.5 million women annually and responsible for the greatest number of cancer-related mortalities among women. In 2018, breast cancer mortalities stood at 627,000 women representing approximately 15% of all c...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/6848703
更新日期:2020-05-24 00:00:00
abstract::The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2005/625182
更新日期:2005-01-01 00:00:00
abstract:Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/9709531
更新日期:2019-11-11 00:00:00
abstract::Ultrasound has been a popular clinical imaging modality for decades. It is well established as a means of displaying the macroscopic anatomy of soft-tissue structures. While conventional ultrasound methodologies (i.e., B-mode and Doppler methods) are well proven and continue to advance technically on a daily basis, e....
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2002/167104
更新日期:2002-01-01 00:00:00
abstract:Background:The systemic immune-inflammation index (SII), based on peripheral lymphocytes, neutrophils, and platelet count, has been used as a prognostic marker for several tumors. However, use of the SII has not been reported for gastric cancer. Methods:We evaluated the prognostic value of the SII in primary and valid...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/1787424
更新日期:2018-12-02 00:00:00
abstract::Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/792679
更新日期:2015-01-01 00:00:00
abstract::Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the lig...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/4823156
更新日期:2019-06-17 00:00:00
abstract::Ovarian cancer is complex disease composed of different histological grades and types. However, the underlying molecular mechanisms involved in the development of different phenotypes remain largely unknown. Epidemiological studies identified multiple exogenous and endogenous risk factors for ovarian cancer developmen...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2007/474320
更新日期:2007-01-01 00:00:00
abstract:Objective:In order to further study the changes of cerebral functional connectivity in patients with toothache (TA), this study used the resting-state functional magnetic resonance imaging (rs-fMRI) technique and degree centrality (DC) analysis method. Methods:Eighteen TA patients (8 males, 10 females) and 18 healthy ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/6683161
更新日期:2020-12-28 00:00:00
abstract::Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2016/9831237
更新日期:2016-01-01 00:00:00
abstract::There is increasing evidence to support the use of CA125 in the follow-up and management of patients with ovarian cancer and several commercial kits are now available for its measurement. This study investigated and compared the performance of three of them: an enzyme immunoassay (EIA) and an immunoradiometric assay (...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract:Purpose:To investigate the expression profiles of long noncoding RNAs (lncRNAs) in patients with atrial fibrillation (AF). Methods:The peripheral blood monocytes of a total of 20 patients with AF and 20 healthy subjects were collected for gene chip technology to detect differentially expressed lncRNAs from 2017.01 to ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8872142
更新日期:2020-11-22 00:00:00
abstract::Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/8629712
更新日期:2017-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2016/8486406
更新日期:2016-01-01 00:00:00
abstract::Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) pati...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/8495326
更新日期:2017-01-01 00:00:00
abstract:Purpose:To determine the frequency of the genotype of signal transducer and activator of transcription protein 3 (STAT3) rs744166, sirtuin (SIRT1) rs12778366, fibroblast growth factor (FGFR2) rs2981582, and advanced glycosylation end product-specific receptor (RAGE) rs1800625 gene polymorphisms in patients with larynge...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3907232
更新日期:2019-11-12 00:00:00
abstract::Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/230307
更新日期:2008-01-01 00:00:00
abstract::Deficiency alleles at the C4 loci within the MHC are associated with autoimmune diseases in Caucasoids and possibly other races. We therefore studied the relationship between relevant C4 alleles and other MHC markers in a random Thai/Chinese population. Over 90 per cent of C4AQO occurs within two supratypes (HLA Aw33,...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract::S-100 protein was demonstrated in 28/31 melanoma tissue sections that had been previously stained by hematoxylin and eosin, including 17 from 19 primary melanomas and 11 from 12 metastases. Additional H & E stained sections from 11 metastatic and 13 primary melanomas were reacted with the monoclonal antibody NKI/C-3 a...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1988-10-01 00:00:00
abstract::Thirty-six coeliac children on gluten-containing diet were studied for AGA IgA and IgG levels. Patients were typed for HLA-A, -B, -C, -DR, -DQ antigens and data were analysed for any correlation between HLA-DR phenotype and AGA levels. AGA IgA and/or IgG were present in all these children. Subjects negative for DR3 or...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract:BACKGROUND:The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population. METHODS:Specimens were ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/912182
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1β and LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimenta...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130974
更新日期:2013-01-01 00:00:00