Abstract:
:Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The meta-analyses were performed using STATA 12.0. Results. 21 studies were yielded. Significant associations were found under heterozygote comparison and dominant model in studies fulfilling HWE (GC versus GG: OR = 0.690, 95% CI = 0.560-0.849, P = 0.000; CC + GC versus GG: OR = 0.690, 95% CI = 0.568-0.838, P < 0.001); significant associations were found under heterozygote comparison and dominant model in Caucasian studies fulfilling HWE (GC versus GG: OR = 0.752, 95% CI = 0.577-0.980, P = 0.035; CC + GC versus GG: OR = 0.737, 95% CI = 0.576-0.944, P = 0.016); significant associations were found under allele comparison, heterozygote comparison, and dominant model in Brazilian population (C versus G: OR = 0.648, 95% CI = 0.497-0.845, P = 0.001; GC versus GG: OR = 0.621, 95% CI = 0.441-0.876, P = 0.007; CC + GC versus GG: OR = 0.649, 95% CI = 0.470-0.896, P = 0.009). Conclusion. IL-6 174 polymorphism is associated with CP susceptibility. In Brazilian and Caucasian population, IL-6 174 GG genotype plays as a risk factor to CP.
journal_name
Dis Markersjournal_title
Disease markersauthors
Zhu J,Guo B,Fu M,Guo W,Yuan Y,Yuan H,Zhang S,Yu Hdoi
10.1155/2016/9612421subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9612421eissn
0278-0240issn
1875-8630journal_volume
2016pub_type
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