Quasimonomorphic mononucleotide repeats for high-level microsatellite instability analysis.

abstract：Background:Epithelial ovarian cancer (EOC) is highly lethal worldwide. Factors involved in the inflammation and hormone-associated signaling pathway play vital roles in EOC carcinogenesis. The transforming growth factor-β- (TGF-β-) activated kinase 1 (MAP3K7) binding protein 2 (TAB2), mediating convergence of inflammat...

journal_title：Disease markers

authors： Huang X,Shen C,Zhang Y,Li Q,Li K,Wang Y,Song Y,Su M,Zhou B,Wang W

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Cystic fibrosis is a monogenic recessive disorder found predominantly in Caucasian population. This disease arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In this study we consider poly T polymorphism c.1210-12T[5], c.1210-12T[7], c.1210-12T[9] (T{5}, T{7}, T{9}...

journal_title：Disease markers

authors： Tabaripour R,Niaki HA,Douki MR,Bazzaz JT,Larijani B,Yaghmaei P

更新日期：2012-01-01 00:00:00

abstract：:Biomarker measurements now support key decisions throughout the drug development process, from lead optimization to regulatory approvals. They are essential for documenting exposure-response relationships, specificity and potency toward the molecular target, untoward effects, and therapeutic applications. In a broader...

journal_title：Disease markers

authors： Swanson BN

更新日期：2002-01-01 00:00:00

abstract：:The terminal portion of the pol gene and the entire env gene of the human endogenous retrovirus ERV3 was screened for polymorphic nucleotides. For this purpose fragments amplified from the desired regions of ERV3 were subjected to single strand conformational analysis (SSCP analysis). Using this approach, we detected ...

journal_title：Disease markers

authors： Rasmussen HB,Clausen J

更新日期：1998-11-01 00:00:00

abstract：:Changes of glycosylation pattern in serum proteins have been linked to various diseases including cancer, suggesting possible development of novel biomarkers based on the glycomic analysis. In this study, N-linked glycans from human serum were quantitatively profiled by matrix-assisted laser desorption ionization time...

journal_title：Disease markers

authors： Kim JH,Park CW,Um D,Baek KH,Jo Y,An H,Kim Y,Kim TJ

更新日期：2014-01-01 00:00:00

abstract：:A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...

journal_title：Disease markers

authors： Kułak-Bejda A,Waszkiewicz N,Bejda G,Zalewska A,Maciejczyk M

更新日期：2019-05-02 00:00:00

abstract：OBJECTIVES:Increases in red blood cell distribution width (RDW) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) predict the mortality of chronic heart failure patients undergoing cardiac resynchronization therapy (CRT). It was hypothesized that RDW is independent of and possibly even superior to NT-proBNP fro...

journal_title：Disease markers

authors： Boros AM,Perge P,Jenei Z,Karády J,Zima E,Molnár L,Becker D,Gellér L,Prohászka Z,Merkely B,Széplaki G

更新日期：2016-01-01 00:00:00

abstract：:Multiple association studies found that the human 9p21.3 chromosome locus is a risk factor for atherosclerosis. The purpose of this study was to investigate the association of the severity and early-onset of coronary artery disease with variant rs1333049 on chromosome 9p21.3 polymorphism and the impact of this variant...

journal_title：Disease markers

authors： Abid K,Mili D,Kenani A

更新日期：2015-01-01 00:00:00

abstract：Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...

journal_title：Disease markers

authors： Fang E,Wang X,Feng J,Zhao X

更新日期：2020-01-07 00:00:00

abstract：Materials and Methods:Relative expression of lncRNAs CARMN, LUCAT1, SMILR, and MALAT1 was tested in clinical aortic tissue and blood plasma samples from TAA and non-TAA patients using the qRT-PCR method. The Mann-Whitney U test was used to compare ΔCt values between the study groups. ROC curve analysis was performed to...

journal_title：Disease markers

authors： Patamsytė V,Žukovas G,Gečys D,Žaliaduonytė D,Jakuška P,Benetis R,Lesauskaitė V

更新日期：2020-06-17 00:00:00

abstract：:In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bla...

journal_title：Disease markers

authors： Liu GM,Xu ZQ,Ma HS

更新日期：2018-09-19 00:00:00

abstract：:The prevalence of heart failure (HF) due to cardiac remodelling after acute myocardial infarction (AMI) does not decrease regardless of implementation of new technologies supporting opening culprit coronary artery and solving of ischemia-relating stenosis with primary percutaneous coronary intervention (PCI). Numerous...

journal_title：Disease markers

authors： Berezin AE,Berezin AA

更新日期：2020-06-12 00:00:00

abstract：AIM:Spindle and kinetochore-associated protein 1 (SKA1) is one subtype of SKA, whose protein can make spindle microtubules attach steadily to the kinetochore in the middle of mitosis. At present, there are fewer researches on the relationship between SKA1 expression and tumor development. METHODS:In this study, immuno...

journal_title：Disease markers

authors： Dong C,Wang XL,Ma BL

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D suppleme...

journal_title：Disease markers

authors： Zaleski A,Panza G,Swales H,Arora P,Newton-Cheh C,Wang T,Thompson PD,Taylor B

更新日期：2015-01-01 00:00:00

abstract：:Antibodies against myelin oligodendrocyte antigens have been found in the immunoreactive brain lesions of Multiple Sclerosis (MS) patients. Recently it has been proposed that these antibodies can be used as a prognostic marker in the course of disease. However, the serum levels of these autoantibodies during different...

journal_title：Disease markers

authors： Angelucci F,Mirabella M,Frisullo G,Caggiula M,Tonali PA,Batocchi AP

更新日期：2005-01-01 00:00:00

abstract：:Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...

journal_title：Disease markers

authors： Zhu J,Guo B,Fu M,Guo W,Yuan Y,Yuan H,Zhang S,Yu H

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis. To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in cell division with clinical outcome, we consecutively...

journal_title：Disease markers

authors： Grossi F,Dal Bello MG,Salvi S,Puzone R,Pfeffer U,Fontana V,Alama A,Rijavec E,Barletta G,Genova C,Sini C,Ratto GB,Taviani M,Truini M,Merlo DF

更新日期：2015-01-01 00:00:00

abstract：:Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...

journal_title：Disease markers

authors： Zhang Q,Di J,Ji Z,Mi A,Li Q,Du X,Wang A,Wang A,Qin C

更新日期：2020-07-08 00:00:00

abstract：:PD1/PDL1 inhibitors have been adopted for the treatment of advanced non-small-cell lung cancer, and PDL1 expression has been investigated as a predictive biomarker for PD1/PDL1 inhibitor therapy. However, PDL1 lacks diagnostic accuracy in differentiating patients who are likely or unlikely to benefit. So, it is urgent...

journal_title：Disease markers

authors： Wu Y,Lin L,Liu X

更新日期：2020-06-09 00:00:00

abstract：:In order to verify the role of CEA in the differential diagnosis of pancreatic cancer and to evaluate some influencing factors like age, tumor spread and liver dysfunction, this antigen was measured in the sera of 60 control subjects, 45 patients with pancreatic cancer, 37 with chronic pancreatitis, 67 with benign, an...

journal_title：Disease markers

authors： Basso D,Fabris C,Del Favero G,Angonese C,Meggiato T,Infantino A,Plebani M,Piccoli A,Leandro G,Burlina A

更新日期：1988-07-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/2138627.]. ...

journal_title：Disease markers

authors： Marrugal Á,Ojeda L,Paz-Ares L,Molina-Pinelo S,Ferrer I

更新日期：2018-07-08 00:00:00

abstract：:Current problems in obtaining suitable monoclonal antibodies (MoAbs) for in vivo imaging and therapy can now be bypassed using protein-engineering rather than conventional hybridoma technology. Rodent antibody binding sites can be grafted onto human acceptor antibodies thus reshaping the human MoAbs into reagents with...

journal_title：Disease markers

authors： Verhoeyen ME,Saunders JA,Broderick EL,Eida SJ,Badley RA

更新日期：1991-05-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to impr...

journal_title：Disease markers

authors： Biskup K,Braicu EI,Sehouli J,Tauber R,Blanchard V

更新日期：2014-01-01 00:00:00

abstract：:Involvement of the ets-1 proto-oncogene located at chromosome band 11q23 was studied in six tumors and in a congenital chromosome abnormality affecting the 11q23 region, in order to determine whether the breakpoint of these rearrangements was identical at the molecular level. In multiple restriction digestions a 5.4 k...

journal_title：Disease markers

authors： Koduru PR,Offit K,Jhanwar SC

更新日期：1989-07-01 00:00:00

abstract：:INHBA-encoded inhibin β A is a member of the transforming growth factor-β (TGF-β) superfamily. INHBA has been reported to be implicated in the progression of multiple types of cancer including ovarian cancer (OC). However, the mechanisms by which INHBA affects OC progression are not well-characterized. The aim of our ...

journal_title：Disease markers

authors： Li X,Yang Z,Xu S,Wang Z,Jin P,Yang X,Zhang Z,Wang Y,Wei X,Fang T,Gao Q

更新日期：2019-11-11 00:00:00

abstract：:The discovery that PSA exists in serum in both free and complexed forms led to development of immunoassays specific for different PSA forms. This helped in measuring free PSA in the presence of PSA-ACT (PSA-alpha antichymotrypsin), hence it was possible to calculate the percent free PSA or free to total PSA ratio, mea...

journal_title：Disease markers

authors： Thakur V,Singh PP,Talwar M,Mukherjee U

更新日期：2003-01-01 00:00:00

abstract：Objective:Several serum markers were reported to reflect the severity of pulmonary alveolar proteinosis (PAP). The aim of this study is to investigate a reliable and facile marker to access and monitor the clinical course of PAP in a large cohort. Methods:PAP patients from January 2010 to June 2018 were enrolled. Hosp...

journal_title：Disease markers

authors： Shi S,Chen L,Qiu X,Zhao Q,Xiao Y,Yan X

更新日期：2019-11-11 00:00:00

abstract：:Chromosomal aneuploidy consists the leading cause of fetal death in our species. Around 50% of spontaneous abortions until 15 weeks of gestational age are chromosomally aneuploid, with trisomies accounting for 50% of the abnormal abortions. Trisomy 21 is the most common chromosome abnormality in liveborns and is usual...

journal_title：Disease markers

authors： Kokotas H,Grigoriadou M,Mikkelsen M,Giannoulia-Karantana A,Petersen MB

更新日期：2009-01-01 00:00:00

abstract：Background:In patients admitted with chest pain and suspected acute coronary syndrome (ACS), it is crucial to early identify those who are at higher risk of adverse events. The study aim was to assess the predictive value of copeptin in patients admitted to the emergency department with chest pain and nonconclusive ECG...

journal_title：Disease markers

authors： Morawiec B,Kawecki D,Przywara-Chowaniec B,Opara M,Muzyk P,Ho L,Tat LC,Gabrysiak A,Muller O,Nowalany-Kozielska E

更新日期：2018-01-24 00:00:00

abstract：BACKGROUND:A novel swine-origin influenza A H1N1 virus (S-OIV) caused human infection and acute respiratory illness in 2009, resulting in an influenza pandemic. OBJECTIVES:This study characterized the immune responses of S-OIV infection in pediatric patients at risk of pulmonary complications. METHODS:All enrolled pe...

journal_title：Disease markers

authors： Wang SM,Liao YT,Hu YS,Ho TS,Shen CF,Wang JR,Lin YS,Liu CC

更新日期：2014-01-01 00:00:00