Abstract:
:Current problems in obtaining suitable monoclonal antibodies (MoAbs) for in vivo imaging and therapy can now be bypassed using protein-engineering rather than conventional hybridoma technology. Rodent antibody binding sites can be grafted onto human acceptor antibodies thus reshaping the human MoAbs into reagents with more desired specificities. We successfully exploited this technology to produce two reshaped human antibodies with the same specificities and very similar binding abilities as demonstrated for the mouse antibodies H17E2 and HMFG1.
journal_name
Dis Markersjournal_title
Disease markersauthors
Verhoeyen ME,Saunders JA,Broderick EL,Eida SJ,Badley RAsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
197-203issue
3-4eissn
0278-0240issn
1875-8630journal_volume
9pub_type
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