Abstract:
:A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabolites. Saliva collection is noninvasive, and self-collection is possible. There is a lack of risk of injuries related to injection with needle, and it is generally safe. Human saliva has been successfully used, for example, in the diagnosis of many systemic diseases like cancers, autoimmunological diseases, infectious diseases (HIV, hepatitis, and malaria), and endocrinological diseases, as well as diseases of the gastrointestinal tract. Also, it is used in toxicological diagnostics, drug monitoring, and forensic medicine. The usefulness of saliva as a biological marker has also been extended to psychiatry. The specificity of mental illness and patients limits or prevents cooperation and diagnosis. In many cases, the use of saliva as a marker seems to be the most sensible choice.
journal_name
Dis Markersjournal_title
Disease markersauthors
Kułak-Bejda A,Waszkiewicz N,Bejda G,Zalewska A,Maciejczyk Mdoi
10.1155/2019/4360612subject
Has Abstractpub_date
2019-05-02 00:00:00pages
4360612eissn
0278-0240issn
1875-8630journal_volume
2019pub_type
杂志文章,评审相关文献
DISEASE MARKERS文献大全abstract::Cytoplasmic islet cell antibodies (ICA) were determined in a group of non-diabetic Caucasian schoolchildren (n = 4208). The prevalence rate for ICA positivity was 1.05 per cent (95 per cent confidence interval: 0.8-1.4 per cent). Analysis of HLA risk factors revealed that HLA-DRB1*03 (p less than 0.01), HLA-DRB1*04 (p...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1991-09-01 00:00:00
abstract::Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/230307
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Impaired fasting glucose (IFG) through the nondiabetic range (100-125 mg/dL) is not considered in the cardiovascular (CV) risk profile. AIM:To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. MATERIAL AND METHODS:Cross-sectional study in 373...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/804739
更新日期:2015-01-01 00:00:00
abstract::Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/4857917
更新日期:2016-01-01 00:00:00
abstract::PIZ allele frequencies were defined by PCR amplification and hybridization using a PIZ SSO (sequence specific oligonucleotide) probe. The groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (RA) without any extra-articular features, 29 of whom had severe arthritis and 31 of whom had mild...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:Background:Breast cancer is the commonest malignancy in women worldwide. It is estimated to affect approximately 1.5 million women annually and responsible for the greatest number of cancer-related mortalities among women. In 2018, breast cancer mortalities stood at 627,000 women representing approximately 15% of all c...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/6848703
更新日期:2020-05-24 00:00:00
abstract:Background:Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by asses...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/9529621
更新日期:2018-12-13 00:00:00
abstract:BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-0892
更新日期:2012-01-01 00:00:00
abstract::There is a known relationship between serum alanine aminotransferase (ALT) and obesity in humans, but the mechanism(s) are not clarified. This study investigated the associations between serum ALT and body composition in an overweight and obese population. The results are based on data from a previous randomized contr...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/1695874
更新日期:2019-08-26 00:00:00
abstract:BACKGROUND:During progression of gastric cancer (GC), degradation of the extracellular matrix is mediated by the matrix metalloproteases (MMPs) and their tissue inhibitors (TIMPs): changes in the expression of these have been related to unfavorable prognosis in GC. OBJECTIVE:To analyze the expression of certain MMPs a...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/285906
更新日期:2014-01-01 00:00:00
abstract::The eukaryotic initiation factor 3 (eIF3) is the largest and most complex translation initiation factor in mammalian cells. It consists of 13 subunits and among which several were implicated to have significant prognostic effects on multiple human cancer entities. To examine the expression profiles of eIF3 subunits an...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/6019637
更新日期:2019-12-07 00:00:00
abstract::Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic charac...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2008/396281
更新日期:2008-01-01 00:00:00
abstract::Apelin plays important roles in cardiovascular homeostasis. However, its effects on the mechanoenergetics of heart failure (HF) are unavailable. We attempted to investigate the effects of apelin on the left ventricular-arterial coupling (VAC) and mechanical efficiency in rats with HF. HF was induced in rats by the lig...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/4823156
更新日期:2019-06-17 00:00:00
abstract::This study evaluated the in vitro sensitivity of paired Leishmania braziliensis samples isolated from the same patient before pentavalent antimonial treatment (Sample A) and after treatment failure or cutaneous leishmaniasis reactivation (Sample B) in patients undergoing intralesional administration or injections (5 m...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/943236
更新日期:2015-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a head and neck cancer that is highly found in distinct geographic areas, such as Southeast Asia. The management of NPC remains burdensome as the prognosis is poor due to the late presentation of the disease and the complex nature of NPC pathogenesis. Therefore, it is necessary to fin...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2015/762128
更新日期:2015-01-01 00:00:00
abstract:Objective:This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods:A cross-sectional study including 180 type 2 diabetic participants was conducted...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/3793768
更新日期:2018-04-16 00:00:00
abstract::Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...
journal_title:Disease markers
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/9612421
更新日期:2016-01-01 00:00:00
abstract::Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/8658507
更新日期:2018-02-26 00:00:00
abstract:BACKGROUND:Papillary thyroid carcinoma (PTC), follicular thyroid adenoma (FTA), and thyroid nodular hyperplasia (TNH) are the most frequent diseases of the thyroid gland. Previous studies described the involvement of dipeptidyl-peptidase IV (DPPIV/CD26) in the development of thyroid neoplasia and proposed it as an addi...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/970736
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0716
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/485687
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS:PON1 activity was evaluated in 91 HIV-1 serone...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/480201
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. METHODS:In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/534534
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. OBJECTIVE:To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/648670
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The molecular work-up of thyroid nodules from fine needle aspiration samples has given clinicians a new level of diagnostic information. The aim of the present study was to evaluate the utility of molecular analysis in thyroid fine needle aspiration samples from a Chinese population. METHODS:Specimens were ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/912182
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/2138627.]. ...
journal_title:Disease markers
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/1404780
更新日期:2018-07-08 00:00:00
abstract::Biomarker measurements now support key decisions throughout the drug development process, from lead optimization to regulatory approvals. They are essential for documenting exposure-response relationships, specificity and potency toward the molecular target, untoward effects, and therapeutic applications. In a broader...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2002/212987
更新日期:2002-01-01 00:00:00
abstract::In this study, we aim to investigate the correlation between circulating tumor cells (CTCs) and the T lymphocyte subsets and NK cells in peripheral blood in non-small-cell lung cancer (NSCLC). The peripheral blood CTCs were determined by SET-iFISH. Flow cytometry was used to determine the distribution of T lymphocyte ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/5727815
更新日期:2017-01-01 00:00:00
abstract:Background:Preeclamptic pregnancies often present an intensified inflammatory state associated with the nuclear activity of NFκB. NEMO is an essential regulator of nuclear factor kappa B (NFκB) in cytoplasmic and nuclear cellular compartments. The aim of the present study is to examine the level and localization of the...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/8418379
更新日期:2019-01-02 00:00:00
abstract::Background. Proper diagnosis of pancreatic lesion etiology is a challenging clinical dilemma. Studies suggest that surgery for suspected pancreatic ductal adenocarcinoma (PDAC) reveals a benign lesion in 5% to 13% of cases. The aim of our study was to assess whether routinely used biomarkers such as CA19-9, Ca125, Ca1...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2017/8629712
更新日期:2017-01-01 00:00:00