Abstract:
:In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bladder cancer using immunohistochemistry and observed that its high expression was associated with recurrence and metastasis. In addition, the transwell assay and wound healing assay showed that cell migration and invasion were decreased with NUCB2 knockdown in T24 and 5637 cells. In vivo, tumor growth and metastasis were inhibited with shRNA treatment in T24 cells. Those results showed that NUCB2 played an important role in bladder cancer and could be considered a potent prognostic factor in bladder cancer.
journal_name
Dis Markersjournal_title
Disease markersauthors
Liu GM,Xu ZQ,Ma HSdoi
10.1155/2018/4272064subject
Has Abstractpub_date
2018-09-19 00:00:00pages
4272064eissn
0278-0240issn
1875-8630journal_volume
2018pub_type
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