Abstract:
:Tumor markers and antigens are normally highly expressed in malignant tissue, but not in the surrounding normal tissue. Serial Analysis of Gene Expression (SAGE) is a technology that counts mRNA transcripts and can be used to find those genes most highly induced in malignant tissues. SAGE produces a comprehensive profile of gene expression and can be used to search for tumor biomarkers in a limited number of samples. Public sources of SAGE data, in particular through the Cancer Genome Anatomy Project, increase the value of this technology by making a large source of information on many tumors and normal tissues available for comparison. Although the perfect tumor-specific gene does not exist, the differences in gene expression between tumor and normal can be exploited for therapeutic or diagnostic purposes.
journal_name
Dis Markersjournal_title
Disease markersauthors
Riggins GJdoi
10.1155/2001/185929subject
Has Abstractpub_date
2001-01-01 00:00:00pages
41-8issue
2eissn
0278-0240issn
1875-8630journal_volume
17pub_type
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