Abstract:
BACKGROUND:A possible association between the TACC3 rs798766 polymorphism and urinary bladder cancer risk has been indicated in published literature. We performed this meta-analysis as a synthesis of all relevant data to summarize currently available evidence and to provide estimation with increased precision. METHODS:EMBASE, PubMed, Google Scholar, and Wanfang Data were searched. "rs798766" and "urinary bladder cancer" were used as the search terms. A total of 6 eligible studies were identified, in which 8194 cases and 50,165 controls were investigated. Meta-analysis was performed using extracted data. Subgroup analysis by ethnicity was also performed. Population attributable risk (PAR) was calculated. RESULTS:We found a significant association between rs798766[T] and increased risk of bladder cancer, allelic[T] OR = 1.27, 95%CI = 1.20-1.33. Subgroup analysis by ethnicity revealed similar results, allelic[T] OR = 1.24, 95%CI = 1.17-1.32 in Caucasian subjects and allelic[T] OR = 1.33, 95%CI = 1.21-1.46 in Asian subjects. PAR based on pooled allelic ORs and the frequency of the risk allele in control subjects was 4.63% in the overall population and 3.92% in Asians and 4.36% in Caucasians. CONCLUSION:rs798766 is associated with increased risk of bladder cancer, and no ethnic difference was found.
journal_name
Dis Markersjournal_title
Disease markersauthors
Meng XY,Shi MJ,Chen JF,Liao Y,Hu BW,Hireche Adoi
10.1155/2017/7850708subject
Has Abstractpub_date
2017-01-01 00:00:00pages
7850708eissn
0278-0240issn
1875-8630journal_volume
2017pub_type
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