Elevated plasma level of leukotrienes in bronchial asthma patients: a possible clinical relevance.

abstract：OBJECTIVES:Increases in red blood cell distribution width (RDW) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) predict the mortality of chronic heart failure patients undergoing cardiac resynchronization therapy (CRT). It was hypothesized that RDW is independent of and possibly even superior to NT-proBNP fro...

journal_title：Disease markers

authors： Boros AM,Perge P,Jenei Z,Karády J,Zima E,Molnár L,Becker D,Gellér L,Prohászka Z,Merkely B,Széplaki G

更新日期：2016-01-01 00:00:00

abstract：:The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...

journal_title：Disease markers

authors： Fernández-Mestre MT,Yehirobi C,Montagnani S,Balbas O,Layrisse Z

更新日期：2005-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection prevalence was determined in 34 hepatocellular carcinoma (HCC) patients with underlying liver cirrhosis. Serum alfa-fetoprotein level was found to be more than 1000 ng/ml (3153 +/- 1451) in those patients. Anti-HCV antibodies were detected in 84% of patients sera negative for hepatiti...

journal_title：Disease markers

authors： Mabrouk GM

更新日期：1997-11-01 00:00:00

abstract：:Changes of glycosylation pattern in serum proteins have been linked to various diseases including cancer, suggesting possible development of novel biomarkers based on the glycomic analysis. In this study, N-linked glycans from human serum were quantitatively profiled by matrix-assisted laser desorption ionization time...

journal_title：Disease markers

authors： Kim JH,Park CW,Um D,Baek KH,Jo Y,An H,Kim Y,Kim TJ

更新日期：2014-01-01 00:00:00

abstract：:HLA typing for antigens of the A, B, C, and DR loci was carried out on lymphocytes from a haemophilic (Type A) family which included four siblings with arthritis. No single haplotype was found to relate to the presence of haemophilia or haemophilic arthritis. ...

journal_title：Disease markers

authors： Steven MM,Sturrock RD,Forbes CD,Dick HM

更新日期：1986-10-01 00:00:00

abstract：Background:The pathogenesis of thoracic aortopathy is complex, and much evidence suggests the influence of genetic factors. Some genes with polymorphisms are widely considered critical factors in the initiation and development of aortic aneurysm. The aim of our study was to analyze the association of genetic polymorphi...

journal_title：Disease markers

authors： Gorący I,Grudniewicz S,Safranow K,Ciechanowicz A,Jakubiszyn P,Gorący A,Brykczyński M

更新日期：2020-09-24 00:00:00

abstract：Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...

journal_title：Disease markers

authors： Su Q,Yang H,Li L

更新日期：2018-06-25 00:00:00

abstract：:To identify the novel, noninvasive biomarkers to assess the outcome and prognosis of breast cancer (BC), patients with high sensitivity and specificity are greatly desired. Herein, the miRNA expression profile and matched clinical features of BC patients were extracted from The Cancer Genome Atlas (TCGA) database. The...

journal_title：Disease markers

authors： Tang J,Ma W,Zeng Q,Tan J,Cao K,Luo L

更新日期：2019-12-30 00:00:00

abstract：:Introduction. Chronic Periodontitis (CP) is suggested to be related to gene variations. Present study aims to quantitatively estimate the association between interleukin-6- (IL-6-) 174G/C polymorphism and CP susceptibility. Materials and Methods. Pubmed, Embase, and Web of Science were searched up to May 2016. The met...

journal_title：Disease markers

authors： Zhu J,Guo B,Fu M,Guo W,Yuan Y,Yuan H,Zhang S,Yu H

更新日期：2016-01-01 00:00:00

abstract：:The recent advances in high-throughput data acquisition have driven a revolution in the study of human disease and determination of molecular biomarkers of disease states. It has become increasingly clear that many of the most important human diseases arise as the result of a complex interplay between several factors ...

journal_title：Disease markers

authors： McDermott JE,Costa M,Janszen D,Singhal M,Tilton SC

更新日期：2010-01-01 00:00:00

abstract：:Regulatory T cells (Tregs) play an essential role in acute coronary syndrome (ACS). However, there is debate about which Treg subsets are truly critical to ACS. Helios, a transcription factor, was recently reported to be a bona fide marker for natural Tregs or activated Tregs with a suppression function, but little is...

journal_title：Disease markers

authors： Jiang L,Chen F,Hu X,Hu Y,Wang Y,Zhang W,Peng Y,Cheng L

更新日期：2017-01-01 00:00:00

abstract：Objective:Long noncoding RNAs (lncRNAs) have been strongly associated with various types of cancer. The present study aimed at exploring the diagnostic and prognostic value of lncRNA Zinc finger protein 667-antisense RNA 1 (ZNF667-AS1) in glioma patients. Patients and Methods. The expressions of ZNF667-AS1 were detecte...

journal_title：Disease markers

authors： Yuan Q,Gao C,Lai XD,Chen LY,Lai TB

更新日期：2020-11-16 00:00:00

abstract：:Cytoplasmic islet cell antibodies (ICA) were determined in a group of non-diabetic Caucasian schoolchildren (n = 4208). The prevalence rate for ICA positivity was 1.05 per cent (95 per cent confidence interval: 0.8-1.4 per cent). Analysis of HLA risk factors revealed that HLA-DRB1*03 (p less than 0.01), HLA-DRB1*04 (p...

journal_title：Disease markers

authors： Boehm BO,Seissler J,Glück M,Manfras BJ,Thomas H,Schmidt K,Rudert WA,Usadel KH,Trucco M,Scherbaum WA

更新日期：1991-09-01 00:00:00

abstract：Purpose:Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate met...

journal_title：Disease markers

authors： Wang CF,Peng SJ,Liu RQ,Yu YJ,Ge QM,Liang RB,Li QY,Li B,Shao Y

更新日期：2020-12-09 00:00:00

abstract：:In order to verify the role of CEA in the differential diagnosis of pancreatic cancer and to evaluate some influencing factors like age, tumor spread and liver dysfunction, this antigen was measured in the sera of 60 control subjects, 45 patients with pancreatic cancer, 37 with chronic pancreatitis, 67 with benign, an...

journal_title：Disease markers

authors： Basso D,Fabris C,Del Favero G,Angonese C,Meggiato T,Infantino A,Plebani M,Piccoli A,Leandro G,Burlina A

更新日期：1988-07-01 00:00:00

abstract：:Nevirapine (NVP) is an effective nonnucleoside reverse transcriptase inhibitor (NNRTI) of particular interest as it is often used in resource limited countries. However, one of the main concerns with the use of NVP is hepatotoxicity and elevation of liver enzymes as a consequence of highly active antiretroviral therap...

journal_title：Disease markers

authors： Wongtrakul J,Thongtan T,Roytrakul S,Kumrapich B,Janphen K,Praparattanapan J,Supparatpinyo K,Smith DR

更新日期：2014-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and ...

journal_title：Disease markers

authors： Giovannoni G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Abdominal aortic aneurysms (AAAs) are characterized by presence of high proteolytic activity, atherosclerotic lesions, extensive transmural inflammation and the presence of variably sized and shaped intraluminal thrombus (ILT). Therefore, we evaluated a possible association between plasma matrix metalloprote...

journal_title：Disease markers

authors： Wiernicki I,Millo B,Safranow K,Gorecka-Szyld B,Gutowski P

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To determine the proportion of initial troponin (cTn) elevations associated with Type I MI versus other cardiovascular and noncardiovascular diagnoses in an emergency department (ED) and whether or not a relationship exists between the cTn level and the likelihood of Type I MI. BACKGROUND:In the ED, cTn is u...

journal_title：Disease markers

authors： Yiadom MY,Jarolim P,Jenkins C,Melanson SE,Conrad M,Kosowsky JM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Lymph node (LN) metastasis was an independent risk factor for stomach cancer recurrence, and the presence of LN metastasis has great influence on the overall survival of stomach cancer patients. Thus, accurate prediction of the presence of lymph node metastasis can provide guarantee of credible prognosis eva...

journal_title：Disease markers

authors： Wu J,Xiao Y,Xia C,Yang F,Li H,Shao Z,Lin Z,Zhao X

更新日期：2017-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is a complex and heterogeneous disease with four consensus molecular subtypes (CMS1-4). LTBP2 is a member of the fibrillin/LTBP super family and plays a critical role in tumorigenesis by activating TGF-β in the CMS4 CRC subtype. So far, the expression and prognostic significance of LTBP2 in CRC...

journal_title：Disease markers

authors： Huang Y,Wang G,Zhao C,Geng R,Zhang S,Wang W,Chen J,Liu H,Wang X

更新日期：2019-03-10 00:00:00

abstract：:Kinesin family member 20A (KIF20A) has been recently reported to be upregulated and associated with increased invasiveness and metastasis in several malignancies. However, the role of KIF20A in colorectal cancer (CRC) is still unclear. This study is aimed at investigating the potential roles of KIF20A in the developme...

journal_title：Disease markers

authors： Zhang Q,Di J,Ji Z,Mi A,Li Q,Du X,Wang A,Wang A,Qin C

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND AND AIM:Because B-type natriuretic peptide is a powerful predictor of heart failure, its capability to predict a fatal outcome in stroke might be limited to the cardioembolic stroke subtype. In this study, we attempt to ascertain the difference in the prognostic value of N-terminal pro-B-type natriuretic pep...

journal_title：Disease markers

authors： Lee SJ,Lee DG,Lim DS,Hong S,Park JS

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To eval...

journal_title：Disease markers

authors： Fan Z,Pan J,Zhang Y,Wang Z,Zhu M,Yang B,Shi L,Jing H

更新日期：2015-01-01 00:00:00

abstract：Background:The role of miR-200c in gastric cancer remains controversial. This study is aimed at clarifying the diagnostic and prognostic value of miR-200c in gastric cancer through a meta-analysis. Methods:A comprehensive literature search of PubMed, Embase, and Ovid library databases was conducted. The studies includ...

journal_title：Disease markers

authors： Huang ZS,Guo XW,Zhang G,Liang LX,Nong B

更新日期：2019-04-04 00:00:00

abstract：:The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spon...

journal_title：Disease markers

authors： Oguz FS,Ocal L,Diler AS,Ozkul H,Asicioglu F,Kasapoglu E,Bozkurt G,Konice M,Carin M

更新日期：2004-01-01 00:00:00

abstract：:In view of the potential uses of cell surface tumour associated antigens in novel anticancer treatment, a study was designed to investigate whether the biological response modifiers interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) could effect the expression of an epitope on the tumour associa...

journal_title：Disease markers

authors： Clark S,McGuckin MA,Hurst T,Ward BG

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:We investigated the relationship between NT-pro-BNP, glomerular filtration rate (GFR), and all-cause mortality rates in a cohort of older people discharged from an internal medicine unit after admission for dyspnoea. PATIENTS AND METHODS:NT-pro-BNP was evaluated in serum samples of 134 patients aged 80 ± 6 ...

journal_title：Disease markers

authors： Fabbian F,De Giorgi A,Pala M,Volpato S,Portaluppi F,Zuliani G,Manfredini R

更新日期：2013-01-01 00:00:00

abstract：:We first investigated the difference in microRNA expression between normal NP cells and degenerative NP cells using gene chip. We have found that the expression of ERK1/2 was decreased with overexpression of miR-155 in normal nucleus pulposus cell. Expression of ERK1/2 was increased with inhibition of miR-155. Overexp...

journal_title：Disease markers

authors： Ye D,Dai L,Yao Y,Qin S,Xie H,Wang W,Liang W

更新日期：2016-01-01 00:00:00

abstract：:Deficiency alleles at the C4 loci within the MHC are associated with autoimmune diseases in Caucasoids and possibly other races. We therefore studied the relationship between relevant C4 alleles and other MHC markers in a random Thai/Chinese population. Over 90 per cent of C4AQO occurs within two supratypes (HLA Aw33,...

journal_title：Disease markers

authors： Kay PH,Grimsley G,Dawkins RL,Charoenwong P

更新日期：1987-03-01 00:00:00