Abstract:
:Nonenzymatic glycosylation or glycation of macromolecules, especially proteins leading to their oxidation, play an important role in diseases. Glycation of proteins primarily results in the formation of an early stage and stable Amadori-lysine product which undergo further irreversible chemical reactions to form advanced glycation endproducts (AGEs). This review focuses these products in lysine rich proteins such as collagen and human serum albumin for their role in aging and age-related diseases. Antigenic characteristics of glycated lysine residues in proteins together with the presence of serum autoantibodies to the glycated lysine products and lysine-rich proteins in diabetes and arthritis patients indicates that these modified lysine residues may be a novel biomarker for protein glycation in aging and age-related diseases.
journal_name
Dis Markersjournal_title
Disease markersauthors
Ansari NA,Moinuddin,Ali Rdoi
10.3233/DMA-2011-0791subject
Has Abstractpub_date
2011-01-01 00:00:00pages
317-24issue
6eissn
0278-0240issn
1875-8630pii
3835211M2133216Rjournal_volume
30pub_type
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