Abstract:
BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the MBL pathway is also a major determinant of the fate of the anaphylatoxins such as C3a and C5a, which are also pro-inflammatory mediators. The MBL2 gene polymorphisms thus control the serum levels of MBL as well as C3a and C5a. OBJECTIVE:This is the first case-control study conducted in India, investigating the role of MBL2 codon 54 A/B polymorphism in asthma pathogenesis. METHODS:A case-control study was performed with a total of 992 adult subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. The MBL2 codon 54 A/B polymorphism was genotyped by PCR-RFLP. RESULTS:Statistical analysis for the codon 54 polymorphism revealed that the wild (A) allele was significantly associated with asthma with OR=1.9, 95% CI (1.4-2.4), and p< 0.001. CONCLUSION:The MBL2 codon 54 A/B polymorphism is significantly associated with asthma and its phenotypic traits as the wild (A/A) genotype confers a significant risk towards the disease in the studied North Indian population.
journal_name
Dis Markersjournal_title
Disease markersauthors
Birbian N,Singh J,Jindal SK,Joshi A,Batra N,Singla Ndoi
10.3233/DMA-2012-0892subject
Has Abstractpub_date
2012-01-01 00:00:00pages
301-8issue
5eissn
0278-0240issn
1875-8630pii
N41LN7633U4K8448journal_volume
32pub_type
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