Association of the wild-type A/A genotype of MBL2 codon 54 with asthma in a North Indian population.

Abstract:

BACKGROUND:High serum MBL level as well as polymorphisms in the mannose-binding lectin 2 (MBL2) gene resulting in MBL deficiency are involved in the mechanism of a number of non-infectious diseases such as asthma, conferring either risk or protection in different population studies. MBL being the first reactant of the MBL pathway is also a major determinant of the fate of the anaphylatoxins such as C3a and C5a, which are also pro-inflammatory mediators. The MBL2 gene polymorphisms thus control the serum levels of MBL as well as C3a and C5a. OBJECTIVE:This is the first case-control study conducted in India, investigating the role of MBL2 codon 54 A/B polymorphism in asthma pathogenesis. METHODS:A case-control study was performed with a total of 992 adult subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. The MBL2 codon 54 A/B polymorphism was genotyped by PCR-RFLP. RESULTS:Statistical analysis for the codon 54 polymorphism revealed that the wild (A) allele was significantly associated with asthma with OR=1.9, 95% CI (1.4-2.4), and p< 0.001. CONCLUSION:The MBL2 codon 54 A/B polymorphism is significantly associated with asthma and its phenotypic traits as the wild (A/A) genotype confers a significant risk towards the disease in the studied North Indian population.

journal_name

Dis Markers

journal_title

Disease markers

authors

Birbian N,Singh J,Jindal SK,Joshi A,Batra N,Singla N

doi

10.3233/DMA-2012-0892

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

301-8

issue

5

eissn

0278-0240

issn

1875-8630

pii

N41LN7633U4K8448

journal_volume

32

pub_type

杂志文章
  • Clinical Value of Combined Determination of Serum B7-H4 with Carcinoembryonic Antigen, Osteopontin, or Tissue Polypeptide-Specific Antigen for the Diagnosis of Colorectal Cancer.

    abstract:Aim:B7-H4 is member of the B7 family that negatively regulates the immune response, which are associated with tumor development and prognosis. The present study is aimed at examining serum B7-H4 expression and exploring its contribution to diagnosis in patients with colorectal cancer. Methods:We determined serum expre...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/4310790

    authors: Wang P,Li C,Zhang F,Ma X,Gai X

    更新日期:2018-09-27 00:00:00

  • The apolipoprotein B/apolipoprotein A-I ratio as a potential marker of plasma atherogenicity.

    abstract:BACKGROUND:The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting t...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2015/591454

    authors: Kaneva AM,Potolitsyna NN,Bojko ER,Odland JØ

    更新日期:2015-01-01 00:00:00

  • Serum interleukin 17 levels in patients with Crohn's disease: real life data.

    abstract:UNLABELLED:The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. METHODS:Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels,...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2014/690853

    authors: Sahin A,Calhan T,Cengiz M,Kahraman R,Aydin K,Ozdil K,Korachi M,Sokmen HM

    更新日期:2014-01-01 00:00:00

  • Ratio of Early Mitral Inflow Velocity to the Global Diastolic Strain Rate and Global Left Ventricular Longitudinal Systolic Strain Predict Overall Mortality and Major Adverse Cardiovascular Events in Hemodialysis Patients.

    abstract:Background:The ratio of early mitral inflow velocity to the global diastolic strain rate (E/E'sr) and global longitudinal systolic strain (GLS) of the left ventricle (LV) are emerging indices of diastolic and systolic functions, respectively, for the LV. Their prognostic significance in the prediction of mortality and ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/7512805

    authors: Huang JC,Su HM,Wu PY,Lee JJ,Lee WH,Chen SC,Chiu YW,Hsu YL,Chang JM,Chen HC

    更新日期:2019-09-05 00:00:00

  • Reshaping human monoclonal antibodies for imaging and therapy.

    abstract::Current problems in obtaining suitable monoclonal antibodies (MoAbs) for in vivo imaging and therapy can now be bypassed using protein-engineering rather than conventional hybridoma technology. Rodent antibody binding sites can be grafted onto human acceptor antibodies thus reshaping the human MoAbs into reagents with...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:

    authors: Verhoeyen ME,Saunders JA,Broderick EL,Eida SJ,Badley RA

    更新日期:1991-05-01 00:00:00

  • Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetic mellitus.

    abstract:BACKGROUND:Some studies have suggested a relation of plasma fibrinogen to the severity of coronary artery disease (CAD). However, whether plasma fibrinogen can predict the presence and severity of CAD in patients with diabetes mellitus has not been determined. METHODS:A total of consecutive 373 diabetic patients with ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2014/485687

    authors: Hong LF,Li XL,Luo SH,Guo YL,Zhu CG,Qing P,Wu NQ,Li JJ

    更新日期:2014-01-01 00:00:00

  • Predictive Markers for the Recurrence of Nonmuscle Invasive Bladder Cancer Treated with Intravesical Therapy.

    abstract::High recurrence rate is one representative characteristic of bladder cancer. Intravesical therapy after transurethral resection is often performed in patients with nonmuscle invasive bladder cancer (NMIBC) to prevent recurrence. Bacillus Calmette-Guérin (BCG) and several anticancer/antibiotic agents, such as mitomycin...

    journal_title:Disease markers

    pub_type: 杂志文章,评审

    doi:10.1155/2015/857416

    authors: Miyata Y,Sakai H

    更新日期:2015-01-01 00:00:00

  • The Elevated Serum Level of IFN-γ in Patients with Failed Back Surgery Syndrome Remains Unchanged after Spinal Cord Stimulation.

    abstract:Objectives:We investigated the influence of spinal cord stimulation (SCS) on IFN-γ, IL-1β, IL-6, TNF-α, IL-10, and TGF-β serum levels in failed back surgery syndrome (FBSS) patients. The study will try to give new insights into the mechanism of SCS action and the role of IFN-γ and other cytokines in neuropathic pain (N...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/2606808

    authors: Kamieniak P,Bielewicz J,Grochowski C,Litak J,Bojarska-Junak A,Daniluk B,Trojanowski T

    更新日期:2019-01-14 00:00:00

  • Serum Chemerin Levels in relation to Osteoporosis and Bone Mineral Density: A Case-Control Study.

    abstract:BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2015/786708

    authors: He J,Li JC,Xie H,Xu ZH,Sun YW,Shan Q

    更新日期:2015-01-01 00:00:00

  • Intestinal Alkaline Phosphatase Deficiency Is Associated with Ischemic Heart Disease.

    abstract:Background:We have previously shown that the deficiency of the gut enzyme intestinal alkaline phosphatase (IAP) is associated with type 2 diabetes mellitus (T2DM) in humans, and mice deficient in IAP develop the metabolic syndrome, a precipitant of T2DM and ischemic heart disease (IHD). We hypothesized that IAP deficie...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/8473565

    authors: Malo J,Alam MJ,Shahnaz M,Kaliannan K,Chandra G,Aziz T,Sarker T,Bala M,Paul R,Saha CK,Karmakar PK,Malo MS

    更新日期:2019-12-13 00:00:00

  • HLA B-27 subtypes in Turkish patients with spondyloarthropathy and healthy controls.

    abstract::The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spon...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2004/565270

    authors: Oguz FS,Ocal L,Diler AS,Ozkul H,Asicioglu F,Kasapoglu E,Bozkurt G,Konice M,Carin M

    更新日期:2004-01-01 00:00:00

  • Apolipoprotein E genotypes in Mexican patients with Parkinson's disease.

    abstract:BACKGROUND:The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. This association has been identified by amyloid deposits and neurofibrillary tangles in the brains of patients with neurodegenerative diseases. ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.3233/DMA-2009-0667

    authors: Gallegos-Arreola MP,Figuera LE,Ortiz GG,Jiménez-Gil FJ,Ramírez-Vega J,Ruíz-Sandoval JL,Puebla-Pérez AM,Troyo-Sanroman R,García-Ortiz JE,Sanchez-Corona J,Zúñiga-González GM

    更新日期:2009-01-01 00:00:00

  • Relationship between Serum Levels of Metalloproteinase-8 and Tissue Inhibitor of Metalloproteinases-1 and Exercise Test Results in Postmenopausal Women.

    abstract::Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2016/7169531

    authors: Mieczkowska J,Rutkowska E,Mosiewicz J,Mosiewicz B

    更新日期:2016-01-01 00:00:00

  • Biochemical changes in patients with combined chronic schistosomiasis and viral hepatitis C infections.

    abstract::This study was undertaken to assess the biochemical changes induced in chronic schistosomiasis and/or chronic HCV, as well as to pinpoint the most significant parameters which could be used as dependable indices for the differentiation of single and coupled infections with or without liver cirrhosis. The selected pati...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2000/732754

    authors: Fahim FA,Esmat AY,Hassan GK,Abdel-Bary A

    更新日期:2000-01-01 00:00:00

  • Elevated plasma level of leukotrienes in bronchial asthma patients: a possible clinical relevance.

    abstract::Plasma from bronchial asthma patients and healthy controls was investigated for the content of lipoxygenase products. After lipid extraction using SEP-PAK C18 Cartridges, the lipoxygenase products were measured by Enzyme-Immunoassay. Elevated chemotactic B4 was found in plasma from asthmatic patients with mean value (...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/1994/121453

    authors: Mansour M,Farouk N,el Maragy A,Radwan I,el-Ahmady O

    更新日期:1995-03-01 00:00:00

  • Corrigendum to "Overexpression of GRK3, Promoting Tumor Proliferation, Is Predictive of Poor Prognosis in Colon Cancer".

    abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...

    journal_title:Disease markers

    pub_type: 已发布勘误

    doi:10.1155/2020/1245645

    authors: Jiang T,Yang C,Ma L,Wu Z,Ye L,Ma X,Li H,Fan J,Yang Y

    更新日期:2020-10-14 00:00:00

  • Identification of human papilloma virus DNA sequence in the hyperplastic epithelium of an oral denture fibroma.

    abstract::The human papilloma virus (HPV) associated with hyperplastic epithelium in an oral denture fibroma was examined by southern blot hybridization. Extracted DNA was hybridized with full length linear HPV type 2a, 6b, 11, 16, 18, 31 and 33 DNAs as a mixed probe only under low stringent conditions. The hybridized bands dig...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:

    authors: Yamaguchi T,Shindoh M,Amemiya A,Notani K,Fukuda H,Sakaoka H,Inoue M,Fujinaga K

    更新日期:1997-04-01 00:00:00

  • Limited value of KAI1/CD82 protein expression as a prognostic marker in human gastric cancer.

    abstract::The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using th...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.3233/DMA-2012-0896

    authors: Knoener M,Krech T,Puls F,Lehmann U,Kreipe H,Christgen M

    更新日期:2012-01-01 00:00:00

  • Human papillomaviruses and non-melanoma skin cancer: basic virology and clinical manifestations.

    abstract::Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldw...

    journal_title:Disease markers

    pub_type: 杂志文章,评审

    doi:10.1155/2007/942650

    authors: Nindl I,Gottschling M,Stockfleth E

    更新日期:2007-01-01 00:00:00

  • Association between Vascular Endothelial Growth Factor Polymorphisms and Age-Related Macular Degeneration: An Updated Meta-Analysis.

    abstract::Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...

    journal_title:Disease markers

    pub_type: 杂志文章,meta分析

    doi:10.1155/2016/8486406

    authors: Barchitta M,Maugeri A

    更新日期:2016-01-01 00:00:00

  • Identification of Long Noncoding RNA APOC1P1 as an Oncogene in Clear Cell Renal Cell Carcinoma.

    abstract::Renal cell carcinoma (RCC) is one of the most common genitourinary cancers worldwide. Previous evidence shows that long noncoding RNA (LncRNA) APOC1P1 plays an important role in cancer development. However, the role of LncRNA APOC1P1 in ccRCC remains to be explored. LncRNA APOC1P1 expression in 283 ccRCC tissues and 3...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2019/2814058

    authors: Sun C,Zhou Z,Shi H,Li F,Zhang G

    更新日期:2019-12-01 00:00:00

  • Nesfatin-1/Nucleobindin-2 Is a Potent Prognostic Marker and Enhances Cell Proliferation, Migration, and Invasion in Bladder Cancer.

    abstract::In recent researches, high expression of nesfatin-1/nucleobindin-2 (NUCB2) is linked to poor prognosis in prostate and colon cancer due to the enhancement in proliferation, migration, and invasion. However, the role of nesfatin-1 in bladder cancer is not clear. In this study, we examined the expression of NUCB2 in bla...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/4272064

    authors: Liu GM,Xu ZQ,Ma HS

    更新日期:2018-09-19 00:00:00

  • Circulating miRNA-155 as a Potential Biomarker for Coronary Slow Flow.

    abstract:Objective:Recent studies have demonstrated that miRNA-155 is involved in the occurrence and development of atherosclerosis. Furthermore, miRNA-155 has emerged as a new indirect marker for inflammation associated with adverse outcomes in oncology and cardiovascular diseases. This study investigated the correlation betwe...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2018/6345284

    authors: Su Q,Yang H,Li L

    更新日期:2018-06-25 00:00:00

  • The serum glycome to discriminate between early-stage epithelial ovarian cancer and benign ovarian diseases.

    abstract::Epithelial ovarian cancer (EOC) is the sixth most common cause of cancer deaths in women because the diagnosis occurs mostly when the disease is in its late-stage. Current diagnostic methods of EOC show only a moderate sensitivity, especially at an early-stage of the disease; hence, novel biomarkers are needed to impr...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2014/238197

    authors: Biskup K,Braicu EI,Sehouli J,Tauber R,Blanchard V

    更新日期:2014-01-01 00:00:00

  • Is human papillomavirus associated with prostate cancer survival?

    abstract::The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infectio...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2013/735843

    authors: Pascale M,Pracella D,Barbazza R,Marongiu B,Roggero E,Bonin S,Stanta G

    更新日期:2013-01-01 00:00:00

  • Immune activation and viral replication after vaccination with an influenza A H1N1 2009 vaccine in HIV-infected children receiving antiretroviral therapy.

    abstract::Immunization with a pandemic influenza A H1N1 2009 was recommended for HIV-infected patients. However, there is limited information concerning the impact of immunization with this vaccine on immune activation and HIV viral replication. In this study, 45 HIV-infected children and adolescents receiving antiretroviral th...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2013/276547

    authors: Onlamoon N,Unpol P,Boonchan M,Sukapirom K,Wittawatmongkol O,Chokephaibulkit K,Ammaranond P,Pattanapanyasat K

    更新日期:2013-01-01 00:00:00

  • Association of high expression of Groβ with clinical and pathological characteristics of unfavorable prognosis in gastrointestinal stromal tumors.

    abstract::GROβ (CXCL2) is a chemokine produced by endotoxin-treated macrophages that mediates inflammation and tumor development. However, little is known about GROβ expression in gastrointestinal stromal tumors (GIST) or the relationship between GROβ expression and clinical attributes of GIST. GROβ expression was examined via ...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2015/171035

    authors: Zhao H,Zhu H,Jin Q,Zhang S,Wang W,Wang D,Huang J

    更新日期:2015-01-01 00:00:00

  • Mass spectrometric screening of ovarian cancer with serum glycans.

    abstract::Changes of glycosylation pattern in serum proteins have been linked to various diseases including cancer, suggesting possible development of novel biomarkers based on the glycomic analysis. In this study, N-linked glycans from human serum were quantitatively profiled by matrix-assisted laser desorption ionization time...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2014/634289

    authors: Kim JH,Park CW,Um D,Baek KH,Jo Y,An H,Kim Y,Kim TJ

    更新日期:2014-01-01 00:00:00

  • The Combination of CA125 and NSE Is Useful for Predicting Liver Metastasis of Lung Cancer.

    abstract:Purpose:Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate met...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2020/8850873

    authors: Wang CF,Peng SJ,Liu RQ,Yu YJ,Ge QM,Liang RB,Li QY,Li B,Shao Y

    更新日期:2020-12-09 00:00:00

  • Absence of correlation between IL-28B gene polymorphisms and the clinical presentation of chronic hepatitis B in an Amazon Brazilian population.

    abstract:OBJECTIVE:The present study investigated the prevalence of the IL-28B polymorphisms rs12979860 and rs8099917 in chronic hepatitis B patients from a case study in Eastern Amazonia. METHODS:In total, 65 chronically infected HBV patients and 97 healthy subjects who were anti-HBc and anti-HBs positive (control group) were...

    journal_title:Disease markers

    pub_type: 杂志文章

    doi:10.1155/2014/534534

    authors: Conde SR,Rocha LL,Ferreira VM,Monteiro JC,Filgueiras NK,Lins PA,dos Santos BT,Freitas FB,Graça Eda S,Demachki S,de Araújo MT,Ishak R,Vallinoto AC

    更新日期:2014-01-01 00:00:00