Abstract:
BACKGROUND:To evaluate serum chemerin levels in patients with osteoporosis and healthy controls and to investigate the relationship between serum chemerin levels and bone mineral density (BMD). METHODS:An age- and gender-matched case-control study was conducted. Pearson's correlation test was performed to investigate the relationship between serum chemerin levels and BMD. RESULTS:There were 93 patients included in the osteoporosis group and 93 matched controls. Serum chemerin level was significantly higher in patients with osteoporosis (87.27 ± 5.80 ng/mL) than patients in control (71.13 ± 5.12 ng/mL) (P < 0.01). There was a negative correlation between femoral bone mineral density and chemerin in both groups (R = -0.395, P < 0.01 in osteoporosis group; R = -0.680, P < 0.01 in control) and also a negative correlation between lumbar bone mineral density with chemerin in both groups (R = -0.306, P < 0.01 in osteoporosis group; R = -0.362, P < 0.01 in control). CONCLUSIONS:Patients with osteoporosis presented a higher level of serum chemerin, which witnessed an inverse correlation with BMD. Further studies are needed to explore the role of chemerin in the pathophysiology of osteoporosis.
journal_name
Dis Markersjournal_title
Disease markersauthors
He J,Li JC,Xie H,Xu ZH,Sun YW,Shan Qdoi
10.1155/2015/786708subject
Has Abstractpub_date
2015-01-01 00:00:00pages
786708eissn
0278-0240issn
1875-8630journal_volume
2015pub_type
杂志文章相关文献
DISEASE MARKERS文献大全abstract::[This corrects the article DOI: 10.1155/2017/1202710.]. ...
journal_title:Disease markers
pub_type: 已发布勘误
doi:10.1155/2020/1245645
更新日期:2020-10-14 00:00:00
abstract::Human papillomaviruses (HPV) infect cutaneous and mucosal epithelia and induce benign and malignant lesions. Non-melanoma skin cancer (NMSC), encompassing basal cell carcinoma and squamous cell carcinoma (SCC), is the most frequent cancer in the Caucasian population, and the incidence has increased dramatically worldw...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2007/942650
更新日期:2007-01-01 00:00:00
abstract:UNLABELLED:Biomarkers can help to identify patients with early-stages or locally advanced non-small cell lung cancer (NSCLC) who have high risk of relapse and poor prognosis. To correlate the expression of seven biomarkers involved in DNA synthesis and repair and in cell division with clinical outcome, we consecutively...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2015/302649
更新日期:2015-01-01 00:00:00
abstract:UNLABELLED:The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. METHODS:Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels,...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/690853
更新日期:2014-01-01 00:00:00
abstract::The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spon...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2004/565270
更新日期:2004-01-01 00:00:00
abstract::Epithelial cancers, including those of the skin and cervix, are the most common type of cancers in humans. Many recent studies have attempted to use Raman spectroscopy to diagnose these cancers. In this paper, Raman spectral markers related to the temporal and spatial effects of cervical and skin cancers are examined ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2008/230307
更新日期:2008-01-01 00:00:00
abstract::Objective. To determine active TGF-β1 (aTGF-β1) levels in serum, skin, and peripheral blood mononuclear cell (PBMC) culture supernatants and to understand their associations with clinical parameters in systemic sclerosis (SSc) patients. Methods. We evaluated serum samples from 56 SSc patients and 24 healthy controls (...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2016/6064830
更新日期:2016-01-01 00:00:00
abstract::To identify the novel, noninvasive biomarkers to assess the outcome and prognosis of breast cancer (BC), patients with high sensitivity and specificity are greatly desired. Herein, the miRNA expression profile and matched clinical features of BC patients were extracted from The Cancer Genome Atlas (TCGA) database. The...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2019/3815952
更新日期:2019-12-30 00:00:00
abstract:Backgrounds:Both pretreatment serum CRP (C-reactive protein) level and ALB (albumin) level have been found to be predictive of survival for multiple malignancies including sarcoma. Since both of the GPS (Glasgow prognostic score) and CAR (C-reactive protein to albumin ratio) are based on the combination of CRP and ALB,...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2020/8736509
更新日期:2020-01-07 00:00:00
abstract:BACKGROUND/AIMS:The frequency of HLA markers associated with rapid progression to AIDS was evaluated in Brazilian patients with AIDS exhibiting or not toxoplasmic retinochoroiditis (TRC). METHODS:98 AIDS patients (25 with TRC, 43 with anti-T. gondii antibodies but without TCR, and 30 without anti-T. gondii antibodies ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2012-00935
更新日期:2012-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...
journal_title:Disease markers
pub_type: 杂志文章,meta分析
doi:10.1155/2016/8486406
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Previous studies on the role of inflammation in the pathophysiology of sickle cell disease (SCD) suggested that the CCR5Δ32 allele, which is responsible for the production of truncated C-C chemokine receptor type 5 (CCR5), could confer a selective advantage on patients with SCD because it leads to a less eff...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/678246
更新日期:2014-01-01 00:00:00
abstract::PIZ allele frequencies were defined by PCR amplification and hybridization using a PIZ SSO (sequence specific oligonucleotide) probe. The groups studied included 64 normal controls, 104 subjects with rheumatoid arthritis (RA) without any extra-articular features, 29 of whom had severe arthritis and 31 of whom had mild...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract:Purpose:To investigate the expression profiles of long noncoding RNAs (lncRNAs) in patients with atrial fibrillation (AF). Methods:The peripheral blood monocytes of a total of 20 patients with AF and 20 healthy subjects were collected for gene chip technology to detect differentially expressed lncRNAs from 2017.01 to ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8872142
更新日期:2020-11-22 00:00:00
abstract::Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its role in human cancers. To investigate the clinical significance of serum anti-CCNY autoantibodies in nonsmall-cell lung carcinoma (NSCLC), the serum levels of CCNY protein in 264 patients with NSCLC, 103 patients with tuberculosis, and 89 healthy ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/935943
更新日期:2013-01-01 00:00:00
abstract::Deficiency alleles at the C4 loci within the MHC are associated with autoimmune diseases in Caucasoids and possibly other races. We therefore studied the relationship between relevant C4 alleles and other MHC markers in a random Thai/Chinese population. Over 90 per cent of C4AQO occurs within two supratypes (HLA Aw33,...
journal_title:Disease markers
pub_type: 杂志文章
doi:
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVES:Elevated humoral responses to cytomegalovirus (CMV) associate with increased risk of cardiovascular disease (CVD) in HIV patients on antiretroviral therapy (ART). To better understand the persistence of CMV humoral responses in relation to CVD, we determined trends in CMV antibody levels over the first 10 ye...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/947432
更新日期:2014-01-01 00:00:00
abstract::A growing interest in the usability of saliva has been observed recently. Using saliva as a diagnostic material is possible because it contains a varied range of composites, organic and inorganic like proteins, carbohydrates, and lipids, which are secreted into saliva. Moreover, this applies to drugs and their metabol...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2019/4360612
更新日期:2019-05-02 00:00:00
abstract:OBJECTIVE:In this study, we sought to investigate the dynamic changes in the levels of TNF-α, IL-1β and LPS in the gingival crevicular fluid (GCF) in a rat model of diabetes mellitus (DM) and periodontitis (PD). Additionally, we evaluated alveolar bone loss and the histopathological response associated with experimenta...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-130974
更新日期:2013-01-01 00:00:00
abstract::Nevirapine (NVP) is an effective nonnucleoside reverse transcriptase inhibitor (NNRTI) of particular interest as it is often used in resource limited countries. However, one of the main concerns with the use of NVP is hepatotoxicity and elevation of liver enzymes as a consequence of highly active antiretroviral therap...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2014/315824
更新日期:2014-01-01 00:00:00
abstract::Vitamin D plays a role in central nervous system (CNS) development. Recent literature focused on vitamin D status in children and adolescents with autism spectrum disorder (ASD), but with inconsistent results. Our case-control study is aimed at evaluating serum 25-hydroxyl-vitamin D (25(OH)D) concentration in children...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/9292560
更新日期:2020-09-18 00:00:00
abstract::The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infectio...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2013/735843
更新日期:2013-01-01 00:00:00
abstract:Background:Obstructive sleep apnea (OSA) was highly prevalent in patients with type 2 diabetes (T2D). Cathepsin S (CTSS), a cysteine protease, is involved in the inflammatory activity in T2D and hypoxia conditions. The aim of the study was to evaluate whether CTSS could be involved in the inflammatory reaction of OSA i...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8819134
更新日期:2020-09-25 00:00:00
abstract::Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic charac...
journal_title:Disease markers
pub_type: 杂志文章,评审
doi:10.1155/2008/396281
更新日期:2008-01-01 00:00:00
abstract:Purpose:To investigate the association of galectin-3 (Gal-3) and soluble ST2 (sST2) and their follow-up changes with the development of heart failure (HF) and echocardiographic parameters of HF (ejection fraction, atrial and ventricular size, left ventricular hypertrophy, e', and E/e') in patients with ST-segment eleva...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2019/9529053
更新日期:2019-10-10 00:00:00
abstract:INTRODUCTION:Amongst the genitourinary cancers, carcinoma of the urinary bladder is one of the leading causes of death in India. Hypermethylation of the CpG islands of gene promoter is one of the earliest and most frequent epigenetic alterations leading to cancer as well as in its development. Several studies have sugg...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0716
更新日期:2010-01-01 00:00:00
abstract::The role of pro-fibrogenic cytokines in the outcome of infections with hepatitis C virus (HCV) and the response to treatment with pegylated interferon-alpha (pegIFNalpha) and ribavirin remains unclear. To address this issue, we assessed hepatic fibrosis and plasma markers pertinent to T-cell mediated fibrogenesis and ...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.3233/DMA-2010-0699
更新日期:2010-01-01 00:00:00
abstract::Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...
journal_title:Disease markers
pub_type: 临床试验,杂志文章
doi:10.1155/2020/3402108
更新日期:2020-01-25 00:00:00
abstract:Background:The systemic immune-inflammation index (SII), based on peripheral lymphocytes, neutrophils, and platelet count, has been used as a prognostic marker for several tumors. However, use of the SII has not been reported for gastric cancer. Methods:We evaluated the prognostic value of the SII in primary and valid...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2018/1787424
更新日期:2018-12-02 00:00:00
abstract:Purpose:Liver metastasis is the final stage of cancer progression and is associated with poor prognosis. Although numerous indicators have been identified as having prognostic value for lung cancer and liver metastasis, liver metastases are still not diagnosed by imaging in many patients. To provide a more accurate met...
journal_title:Disease markers
pub_type: 杂志文章
doi:10.1155/2020/8850873
更新日期:2020-12-09 00:00:00