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Serum interleukin 17 levels in patients with Crohn's disease: real life data.

Abstract：

UNLABELLED:The aim of this study was to investigate serum IL17 levels in patients with Crohn's disease (CD) and to investigate the relationship between serum IL17 levels with disease activity. METHODS:Fifty patients with CD and sex- and age-matched 40 healthy controls were included in the study. The serum IL17 levels, complete blood count, blood chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured, and Crohn's disease activity was calculated using Crohn's disease activity index (CDAI). RESULTS:The mean serum IL17 level of CD patients did not differ from those of healthy controls (P > 0.05). There was no difference between the mean serum IL levels of active CD patients and of quiescent CD patients (P > 0.05). However, the mean IL17 level of active patients was lower than of control subjects (P = 0.02). Serum IL17 was not correlated with inflammatory markers (ESR, CRP, white blood count, platelet count, and albumin) and CDAI. CONCLUSIONS:Peripheral blood serum IL17 levels of CD patients were not higher than of healthy controls, and also, serum IL17 level was not correlated with clinical disease activity. Peripheral IL17 measurement is not a useful tool for detecting and monitoring Crohn's disease which is understood to have complex etiopathogenesis.

journal_name

Dis Markers

journal_title

Disease markers

authors

Sahin A,Calhan T,Cengiz M,Kahraman R,Aydin K,Ozdil K,Korachi M,Sokmen HM

doi

10.1155/2014/690853

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

690853

eissn

0278-0240

issn

1875-8630

journal_volume

2014

pub_type

杂志文章

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