Identification of Pathogenic Genes of Nonsyndromic Hearing Loss in Uyghur Families Using Massively Parallel DNA Sequencing Technique.

abstract：:Nasopharyngeal carcinoma (NPC) is a head and neck cancer that is highly found in distinct geographic areas, such as Southeast Asia. The management of NPC remains burdensome as the prognosis is poor due to the late presentation of the disease and the complex nature of NPC pathogenesis. Therefore, it is necessary to fin...

journal_title：Disease markers

authors： Janvilisri T

更新日期：2015-01-01 00:00:00

abstract：:Oncogenic activation of the Wnt/ β -catenin signaling pathway is common in human cancers. The secreted frizzled-related proteins (SFRPs) function as negative regulators of Wnt signaling and have important implications in carcinogenesis. Because there have been no reports about the role of SFRP3 in hepatocellular carci...

journal_title：Disease markers

authors： Lin YW,Shih YL,Lien GS,Suk FM,Hsieh CB,Yan MD

更新日期：2014-01-01 00:00:00

abstract：Background:Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory markers with CVD recurrent events. Here, we explored this potential link by asses...

journal_title：Disease markers

authors： Khadir A,Kavalakatt S,Dehbi M,Alarouj M,Bennakhi A,Tiss A,Elkum N

更新日期：2018-12-13 00:00:00

abstract：:Decreased levels of brain-derived neurotrophic factor (BDNF) are assumed to play a crucial role in the pathophysiology of mild neurocognitive disorders (MNCDs). In this study, we compared plasma BDNF levels (at baseline and after two months of treatment with escitalopram) in patients with the main types of MNCDs and n...

journal_title：Disease markers

authors： Levada OA,Cherednichenko NV,Trailin AV,Troyan AS

更新日期：2016-01-01 00:00:00

abstract：:Kidney insufficiency is a hallmark of nephropathia epidemica (NE). Little is known about the mechanisms of the NE kidney pathology, with current knowledge mainly based on findings in postmortem tissue. We have analyzed kidney damage biomarkers in urine collected from early- and late-phase NE using Bio-Plex kidney toxi...

journal_title：Disease markers

authors： Martynova EV,Maksudova AN,Shakirova VG,Abdulkhakov SR,Khaertynova IM,Anokhin VA,Ivanova VV,Abiola IM,Garanina EE,Tazetdinova LG,Valiullina AH,Khaiboullina SF

更新日期：2018-02-26 00:00:00

abstract：Background:Analysis of the correlation between diabetes type 2 (DT2) and serum N-acetyl-β-hexosaminidase (HEX) activity with parameters of fat metabolism and symptoms of anxiety and depression. Material and Method:The study was performed using a random sample of 40 DT2 patients (22 women and 18 men) between the ages o...

journal_title：Disease markers

authors： Chojnowska S,Cabaj-Wiater I,Mikulska-Baran A,Zalewska-Szajda B,Waszkiewicz N

更新日期：2018-06-20 00:00:00

abstract：:Over the last two decades, significant data has been accumulated linking Glutatione S-Transferases (GSTs) with the development of several diseases. Contemporary studies have demonstrated the impact of ethnicity on GST allele frequencies. The aim is to verify if the variability of GST genes reflects population demograp...

journal_title：Disease markers

authors： Polimanti R,Piacentini S,De Angelis F,De Stefano GF,Fuciarelli M

更新日期：2011-01-01 00:00:00

abstract：:Malignant mesothelioma (MM) is an aggressive malignancy of the serosal membranes. Early diagnosis and accurate prognostication remain problematic. BAP1 is a tumour suppressor gene commonly mutated in MM. Germline BAP1 mutation has been associated with early onset and less aggressive disease compared with sporadic MM. ...

journal_title：Disease markers

authors： Pulford E,Huilgol K,Moffat D,Henderson DW,Klebe S

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Evidence indicates that microRNAs (miRNA) play a role in the pathogenesis of chronic kidney diseases (CKD). We explored the possibility of using urinary miRNA as non-invasive biomarkers for CKD. METHODS:We quantified miRNA expression in urinary sediment of 56 CKD patients who underwent kidney biopsy. Patien...

journal_title：Disease markers

authors： Szeto CC,Ching-Ha KB,Ka-Bik L,Mac-Moune LF,Cheung-Lung CP,Gang W,Kai-Ming C,Kam-Tao LP

更新日期：2012-01-01 00:00:00

abstract：:We evaluated the occurrence of mutations in P53, K-RAS, COX-2, expression of COX-2 and hTERT and relations among clinicopathological signs. P53 mutations were identified in 34.4% of tumours, the majority of them occurring in SCC (squamous cell carcinoma, 55.6%). K-RAS was mutated in 12.2% of NSCLC tumours, the majorit...

journal_title：Disease markers

authors： Strazisar M,Rott T,Glavac D

更新日期：2008-01-01 00:00:00

abstract：:soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that f...

journal_title：Disease markers

authors： Thunø M,Macho B,Eugen-Olsen J

更新日期：2009-01-01 00:00:00

abstract：Objective:To evaluate the performance of serum and urinary sCD163 concentrations as possible biomarker in systemic sclerosis (SSc). Methods:Urine and serum samples were obtained from SSc patients and age- and sex-matched controls. Serum and urinary sCD163 concentrations were measured by commercially available ELISA ki...

journal_title：Disease markers

authors： Frantz C,Pezet S,Avouac J,Allanore Y

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Soluble vascular endothelial growth factor (VEGF) is a promising biomarker in monitoring rheumatoid arthritis (RA), but studies of pre-analytical and biologic variability are few. METHODS:VEGF was measured by ELISA methods in serum and plasma from healthy persons and RA patients. Pre-analytical factors were...

journal_title：Disease markers

authors： Hetland ML,Christensen IJ,Lottenburger T,Johansen JS,Svendsen MN,Hørslev-Petersen K,Nielsen L,Nielsen HJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Paraoxonase-1 (PON1) activity is suggested to be altered in individuals infected with human immunodeficiency virus type-1 (HIV-1). We investigated PON1 activity in individuals receiving different regimens of highly active antiretroviral therapy (HAART). METHODS:PON1 activity was evaluated in 91 HIV-1 serone...

journal_title：Disease markers

authors： Maselli LM,da Cunha J,Gutierrez EB,Maranhão RC,Spada C,Bydlowski SP

更新日期：2014-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is a complex and heterogeneous disease with four consensus molecular subtypes (CMS1-4). LTBP2 is a member of the fibrillin/LTBP super family and plays a critical role in tumorigenesis by activating TGF-β in the CMS4 CRC subtype. So far, the expression and prognostic significance of LTBP2 in CRC...

journal_title：Disease markers

authors： Huang Y,Wang G,Zhao C,Geng R,Zhang S,Wang W,Chen J,Liu H,Wang X

更新日期：2019-03-10 00:00:00

abstract：Objectives:Periodontal disease is prevalent and has an inflammation associated with not only oral but also systemic pathologies. The diagnosis by biomarkers is required for clinical practice on periodontal disease. The lactoferrin and α1-antitrypsin were both inflammation-related molecules. The present study investigat...

journal_title：Disease markers

authors： Koshi R,Kotani K,Ohtsu M,Yoshinuma N,Sugano N

更新日期：2018-11-07 00:00:00

abstract：:Background and Objective. The main purpose of this study was to develop a simple automatic diagnostic classification scheme for chemotherapy-induced peripheral neuropathy. Methods:This was a prospective cohort study that enrolled patients with colorectal or gynecologic cancer post chemotherapy for more than 1 year. T...

journal_title：Disease markers

authors： Huang HW,Wu PY,Su PF,Li CI,Yeh YM,Lin PC,Hsu KF,Shen MR,Chang JY,Lin CK

更新日期：2020-01-25 00:00:00

abstract：:Basal cell carcinoma (BCC) is the world's leading skin cancer in terms of frequency at the moment and its incidence continues to rise each year, leading to profound negative psychosocial and economic consequences. UV exposure is the most important environmental factor in the development of BCC in genetically predispos...

journal_title：Disease markers

authors： Lupu M,Caruntu C,Ghita MA,Voiculescu V,Voiculescu S,Rosca AE,Caruntu A,Moraru L,Popa IM,Calenic B,Greabu M,Costea DE

更新日期：2016-01-01 00:00:00

abstract：:The genetic variation at the Apolipoprotein E locus (APOE) is an important determinant of plasma lipids and has been implicated in various human pathological conditions. The objective of the present study was to estimate the distribution of APOE alleles in five Venezuelan communities: two Amerindian tribes (Bari and Y...

journal_title：Disease markers

authors： Fernández-Mestre MT,Yehirobi C,Montagnani S,Balbas O,Layrisse Z

更新日期：2005-01-01 00:00:00

abstract：:The role of human papillomavirus (HPV) in prostate carcinogenesis is highly controversial: some studies suggest a positive association between HPV infection and an increased risk of prostate cancer (PCa), whereas others do not reveal any correlation. In this study, we investigated the prognostic impact of HPV infectio...

journal_title：Disease markers

authors： Pascale M,Pracella D,Barbazza R,Marongiu B,Roggero E,Bonin S,Stanta G

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Acute gangrenous appendicitis (AGA) is a common medical condition; however, the grade of appendicitis usually cannot be established preoperatively. We have attempted to identify some indicators, such as the mean platelet volume (MPV) and the platelet distribution width (PDW), to diagnose AGA. Aims. To eval...

journal_title：Disease markers

authors： Fan Z,Pan J,Zhang Y,Wang Z,Zhu M,Yang B,Shi L,Jing H

更新日期：2015-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. Obesity is the most common and well-established risk factor for NAFLD, but there are large interindividual differences in the relationship between weight status and the development of NAFLD. Beta-3-adrenergic receptor (ADRB3)...

journal_title：Disease markers

authors： Sakamoto Y,Oniki K,Kumagae N,Morita K,Otake K,Ogata Y,Saruwatari J

更新日期：2019-12-17 00:00:00

abstract：:This study was undertaken to assess the biochemical changes induced in chronic schistosomiasis and/or chronic HCV, as well as to pinpoint the most significant parameters which could be used as dependable indices for the differentiation of single and coupled infections with or without liver cirrhosis. The selected pati...

journal_title：Disease markers

authors： Fahim FA,Esmat AY,Hassan GK,Abdel-Bary A

更新日期：2000-01-01 00:00:00

abstract：:Accumulating evidence suggests that the tumor microenvironment has a profound influence on tumor initiation and progression, opening a new avenue for studying tumor biology. Nonetheless, the prognostic values of the peritumoral expression of EpCAM and CD13 remain to be elucidated in hepatocellular carcinoma (HCC) pati...

journal_title：Disease markers

authors： Dai XM,Huang T,Yang SL,Zheng XM,Chen GG,Zhang T

更新日期：2017-01-01 00:00:00

abstract：:Physical activity as a part of the lifestyle is a significant factor influencing health condition. Exercises that require stamina are of particular importance. Oxygen metabolism, which is a significant part of all longer training processes, has an influence on cardiovascular and respiratory system functioning as well ...

journal_title：Disease markers

authors： Mieczkowska J,Rutkowska E,Mosiewicz J,Mosiewicz B

更新日期：2016-01-01 00:00:00

abstract：:Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine aminotransferase (ALT). However, the association of AST/ALT ratio with brain ...

journal_title：Disease markers

authors： Yokoyama M,Watanabe T,Otaki Y,Takahashi H,Arimoto T,Shishido T,Miyamoto T,Konta T,Shibata Y,Daimon M,Ueno Y,Kato T,Kayama T,Kubota I

更新日期：2016-01-01 00:00:00

abstract：:Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and ...

journal_title：Disease markers

authors： Giovannoni G

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Despite the many studies examining thyroid cancers, the effect of thyroid autoantibodies on differentiated thyroid carcinoma (DTC) remains unclear. OBJECTIVE:To investigate the association between serologic thyroid autoantibodies (ATAs) and DTC, we retrospectively evaluated data of thyroid nodules obtained ...

journal_title：Disease markers

authors： Qin J,Yu Z,Guan H,Shi L,Liu Y,Zhao N,Shan Z,Han C,Li Y,Teng W

更新日期：2015-01-01 00:00:00

abstract：:The recent advances in high-throughput data acquisition have driven a revolution in the study of human disease and determination of molecular biomarkers of disease states. It has become increasingly clear that many of the most important human diseases arise as the result of a complex interplay between several factors ...

journal_title：Disease markers

authors： McDermott JE,Costa M,Janszen D,Singhal M,Tilton SC

更新日期：2010-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the most common cause of blindness in elderly people worldwide and the major degenerative disease of the retina that leads to progressive impairment of central vision. Several polymorphisms in different genes have been proposed as factors that increase the disease susceptibili...

journal_title：Disease markers

authors： Barchitta M,Maugeri A

更新日期：2016-01-01 00:00:00