Abstract:
:soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. Studies suggest that full-length suPAR is a regulator of uPAR/uPA by actingas uPA-scavenger, whereas the cleaved suPAR(II-III) act as a chemotactic agent promoting the immune response via the SRSRY sequence in the linker-region. This review focus on the various suPAR fragments and their involvement in inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions.
journal_name
Dis Markersjournal_title
Disease markersauthors
Thunø M,Macho B,Eugen-Olsen Jdoi
10.3233/DMA-2009-0657subject
Has Abstractpub_date
2009-01-01 00:00:00pages
157-72issue
3eissn
0278-0240issn
1875-8630pii
H0877UXU83764462journal_volume
27pub_type
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